The stratification of gastric cancer risk in Latin America

Morgan, Douglas R.; Torres, Javier

doi:10.1016/j.rgmx.2013.08.001

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…There are three recognized high risk regions worldwide, Eastern Asia, Central and Eastern Europe and Latin America. While there may be over-diagnoses in Eastern Asian countries [2], underreporting has been a concern for Latin American countries [3]. Interestingly, compared with the other high risk regions, Lati American countries show more pronounced geographical variations in gastric cancer incidence and mortality [4], even marked variations within countries [5].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for gastric precancerous and cancers lesions in Latin American counties with difference gastric cancer risk

Flores-Luna

Bravo

Kasamatsu

et al. 2020

Cancer Epidemiology

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Objective: To evaluate the risk factors associated with pre-neoplastic lesions and gastric cancer in countries with different cancer risk in Latin America.Methods: 1222 questionnaires of risk factors related to pre-neoplastic lesions and gastric cancer were obtained from patients from Mexico (N=559), Colombia (N=461) and Paraguay (N=202), who were treated at the gastroenterology or oncology service of participant hospitals. In addition, biopsies specimens to establish histological diagnosis and blood to detect IgG antibodies against Helicobacter-pylori (H. pylori) whole-cell antigens and CagA protein using an ELISA were collected. These consisted of 205 gastric cancer, 379 pre-neoplastic (intestinal metaplasia (IM) / *

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Section: Introductionmentioning

confidence: 99%

Risk factors for gastric precancerous and cancers lesions in Latin American counties with difference gastric cancer risk

Flores-Luna

Bravo

Kasamatsu

et al. 2020

Cancer Epidemiology

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“…The chronic outcome is understandable considering that H. pylori, over the millennia of human infections, has established multiple mechanisms to evade our immune responses through fast and confluent adaptation by high mutation rates and antigenic variation 27 combined with dysregulation of T-cell responses (reviewed in 28 ). The many escape routes are reflected in both the shortcomings of conventional H. pylori vaccine development 29 and the high re-infection rate in many parts of the world after eradication of infection with antibiotics 30,31 .…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pyloriattachment-blocking antibodies protect against duodenal ulcer disease

Bugaytsova,

Moonens,

Piddubnyi

et al. 2023

Preprint

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The majority of the world population carry the gastric pathogen Helicobacter pylori. Fortunately, most individuals experience only low-grade or no symptoms, but in many cases the chronic inflammatory infection develops into severe gastric disease, including duodenal ulcer disease and gastric cancer. Here we report on a protective mechanism where H. pylori attachment and accompanying chronic mucosal inflammation can be reduced by antibodies that are present in a vast majority of H. pylori carriers. These antibodies block binding of the H. pylori attachment protein BabA by mimicking the BabA binding to the ABO blood group glycans in the gastric mucosa. However, many individuals demonstrate low titers of BabA blocking antibodies, which is associated with an increased risk for duodenal ulceration, suggesting a role for these antibodies in preventing gastric disease.

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“…(17) Although it is a worldwide problem, its incidence varies across countries, where the incidence is high in Japan, Korea, China, Taiwan, Honduras, Salvador, and is low in India, Australia, Thailand, and New Zealand. (16, 18) Differences in incidence have led to a wide disparity in the management of patients with this premalignant condition. In Japan there is universal screening of the population, while in countries with a low incidence rate, screening is not considered cost effective.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic surveillance of gastrointestinal premalignant lesions

Ballester¹,

Cruz‐Correa

2014

Current Opinion in Gastroenterology

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Purpose of the Review Provide an evidenced-based resource for the surveillance of gastrointestinal premalignant lesions, focusing on the scientific articles reported recently. Recent Findings No randomized controlled clinical trials exist to definitively support the efficacy of surveillance programs for Barrett’s esophagus and gastric intestinal metaplasia. However, surveillance of these premalignant lesions is recommended by some of the leading organizations. To optimize the usefulness of surveillance programs, targeting high-risk patients might maximize its benefits. A Barrett’s esophagus segment of ≥ 3cm and evidence of intestinal metaplasia can help stratify those patients at highest risk for progression to esophageal adenocarcinoma. The location, extent, and severity of intestinal metaplasia are indicators of risk of developing gastric cancer. Patients with extensive intestinal metaplasia should be offered endoscopic surveillance. Quality in the baseline colonoscopy is crucial, in order to decrease the risk of interval colorectal cancers. The importance of serrated polyps is emphasized as well as their surveillance intervals. Summary To optimize the usefulness of surveillance programs, targeting high-risk patients might maximize its benefits. Future research is needed to design more effective surveillance strategies. Recently emerging imaging techniques hold promise for improving sensitivity of endoscopic surveillance of premalignant conditions in the gastrointestinal track.

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The stratification of gastric cancer risk in Latin America

Cited by 3 publications

References 9 publications

Risk factors for gastric precancerous and cancers lesions in Latin American counties with difference gastric cancer risk

Risk factors for gastric precancerous and cancers lesions in Latin American counties with difference gastric cancer risk

Helicobacter pyloriattachment-blocking antibodies protect against duodenal ulcer disease

Endoscopic surveillance of gastrointestinal premalignant lesions

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