Risk factors for gastric precancerous and cancers lesions in Latin American counties with difference gastric cancer risk

Flores-Luna, Lourdes; Bravo, María Mercedes; Kasamatsu, Elena; Ponce, Eduardo; Martínez, Teresa; Torres, Javier; Camorlinga‐Ponce, Margarita; Kato, Ikuko

doi:10.1016/j.canep.2019.101630

Cited by 22 publications

(20 citation statements)

References 45 publications

(64 reference statements)

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“…Even though the association remains controversial 43 , the link between atrophic gastritis and thrombotic risk should be further investigated. Regarding the relation between smoking and histologic extent of AGIM, our findings revealed that smoking was associated with AGIM, as in other similar studies of dyspeptic patients 44 , or with endoscopic lesions. The underlying mechanisms seem to be related to the influence on mucosal cell death, proliferation, decreased blood flow, or modulation of the immune responses in gastric mucosa 45 .…”

Section: Discussionsupporting

confidence: 88%

Cytokine TGF-β1, TNF-α, IFN-γ and IL‐6 Gene Polymorphisms and Localization of Premalignant Gastric Lesions in Immunohistochemically H. pylori-negative Patients

Negovan¹,

Iancu²,

Tripon³

et al. 2021

Int. J. Med. Sci.

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Background: Cytokines and their gene variants are proven to play a role in pathogenic gastritis and carcinogenesis. The study assesses associations of the cytokine gene polymorphisms with extension of atrophic gastritis/intestinal metaplasia (AGIM) in patients without Helicobacter pylori infection on immunohistochemistry study. Methods: 224 adult consecutive patients undergoing an upper digestive endoscopy were included and grouped according to localization of AGIM: 37 patients with antrum-limited AGIM, 21 corpus-limited AGIM, 15 extended-AGIM (antrum and corpus) and 151 patients had no AGIM. Medical records of the patients were checked and a structured direct interview was applied in order to collect clinical data, including digestive symptoms. In all cases, IFN-γ +874T>A, TGF-β1 +869T>C, TNF‐α -308G>A and -238G>A, and IL-6 - 174C>G polymorphisms were genotyped. Results: The mean age was significantly higher in the AGIM group, while the comorbidies were similar among patients with different localization of lesions or in patients without AGIM. There were no significant differences in digestive symptoms, nor in the consumption of non-steroidal anti-inflammatory drugs or proton pump inhibitor with the different extensions of AGIM. There was a significant association between oral anticoagulant consumption and localization of AGIM ( P = 0.042), frequency being higher among patients with corpus-limited AGIM than those with no AGIM ( P = 0.007, adjusted P = 0.041). TGF-β1 +869T>C was less frequent among patients with corpus-limited AGIM ( n =7, 33.3%) and extended AGIM ( n =5, 33.3%) than in antrum-limited AGIM ( n =25, 67.6%). There were no other significant differences regarding variant and wild genotype frequencies of IFN-γ +874T>A (86.5%, 81.0%, 86.7%, p=0.814), TNF‐α -308G>A (35.1%, 28.6%, 53.3%, p=0.48) and IL-6 - 174C>G (70.3%. 61.9%, 73.3% p=0.656) among patients with antrum-limited, corpus-limited or extended AGIM. TGF-β1 +869T>C was associated with a decreased risk for corpus-affected AGIM (adjusted odds ratio: 0.42, 95% confidence interval: 0.19-0.93, P = 0.032). The dominant inheritance models no revealed significant association for IFN-γ +874T>A, TNF‐α -308G>A and IL-6 - 174C>G gene polymorphism and the risk of localization of AGIM. Conclusion: TGF-β1 +869T>C gene polymorphism is associated with a decreased risk for corporeal localization of premalignant lesions, while IFN-γ +874T>A, TNF-α -308G>A and ...

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Section: Discussionsupporting

confidence: 88%

Cytokine TGF-β1, TNF-α, IFN-γ and IL‐6 Gene Polymorphisms and Localization of Premalignant Gastric Lesions in Immunohistochemically H. pylori-negative Patients

Negovan¹,

Iancu²,

Tripon³

et al. 2021

Int. J. Med. Sci.

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“…Our study combined previous studies on the risk factors of GC in Ningxia [ 15 , 16 ] and reports of related domestic studies [ 4 – 6 , 10 – 14 , 17 ]. From the demographic factors, environmental factors, lifestyle, genetic susceptibility, and other factors combined with the clinical test results of Hp and PG to analyze the related factors of gastric carcinogenesis, then confirmed that gender, age, ethnic group, drinking water, pickled products, Hp infection, family history, and PGR were important risk factors for gastric carcinogenesis in our area.…”

Section: Discussionmentioning

confidence: 67%

“…Finding and establishing screening methods and standards for screening high-risk populations of GC in line with China's national conditions have important practical significance. Studies have shown [ 4 , 5 ] that the carcinogenesis and development of GC were caused by a combination of external environmental factors such as population, lifestyle, diet, infection, social economy, and internal genetic factors such as a family history of tumors. In this article, we have established a scoring model for high-risk populations of GC through statistical logistic regression analysis and receiver operating characteristic (ROC) curve through the risk factors of GC, having combined the patients' PG levels and Hp infection rates, and to explore the opportunistic screening methods for GC suitable for China's national conditions.…”

Section: Introductionmentioning

confidence: 99%

Establish a Scoring Model for High-Risk Population of Gastric Cancer and Study on the Pattern of Opportunistic Screening

Tao

Wang

Guo

et al. 2020

Gastroenterology Research and Practice

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Objective. To investigate and study the related risk factors of gastric cancer (GC) patients, to establish a high-risk scoring model of GC by multiple logistic regression analysis, and to explore the establishment of a GC screening mode with clinical opportunistic screening as the main method, and by using the pattern of opportunistic screening to establish the screening of high-risk GC patients and the choice of screening methods in the clinical outpatient work. Methods. Collected the epidemiological questionnaire of 99 GC cases and 284 non-GC patients (other chronic gastric diseases and normal) diagnosed by the General Hospital of Ningxia Medical University from October 2017 to March 2019. Serum pepsinogen (PG) levels were measured by enzyme-linked immunosorbent assay (ELISA) and confirmed Helicobacter pylori (Hp) infection in gastric mucosa tissues by Giemsa staining. Determined the high-risk factors and established a scoring model through unconditional logistic regression model analysis, and the ROC curve determined the cut-off value. Then, we followed up 26 patients of nongastric cancer patients constituted a validation group, which validated the model. Results. The high-risk factors of GC included age≥55, male, drinking cellar or well water, family history of GC, Hp infection, PGI≤43.6 μg/L, and PGI/PGII≤2.1. Established the high-risk model: Y=A×age+30×gender+30×drinking water+30×Hp infection+50×family history of GC+B×PG level. The ROC curve determined that the cut-off value for high-risk GC population was ≥155, and the area under the curve (AUC) was 0.875, the sensitivity and specificity were 87.9% and 71.5%. Conclusions. According to the risk factors of GC, using statistical methods can establish a high-risk scoring model of GC, and the score≥155 is divided into the screening cut-off value for high-risk GC population. Using this model for clinical outpatient GC screening is cost-effective and has high sensitivity and specificity.

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“…Among factors affecting cancer onset, dietary habits play an important role [ 150 , 151 , 152 ]: salt-preserved foods and smoked meats potentiate carcinogenic effects of H. pylori infection [ 153 ], whereas fruits, vegetables, and WGs are protective factors [ 154 , 155 ]. A prospective population-based case-control study reported in men, but not in women, a modestly lower risk of stomach cancer with diet patterns high in WGs, only when combined with citrus fruit and vegetables [ 156 ].…”

Section: Whole Grains and Gastric Cancermentioning

confidence: 99%

The Impact of Whole Grain Intake on Gastrointestinal Tumors: A Focus on Colorectal, Gastric, and Esophageal Cancers

et al. 2020

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Cereals are one of staple foods in human diet, mainly consumed as refined grains. Nonetheless, epidemiological data indicate that whole grain (WG) intake is inversely related to risk of type 2 diabetes, cardiovascular disease, and several cancer types, as well as to all-cause mortality. Particularly responsive to WG positive action is the gastrointestinal tract, daily exposed to bioactive food components. Herein, we shall provide an up-to-date overview on relationship between WG intake and prevention of gastrointestinal tumors, with a particular focus on colorectal, stomach, and esophagus cancers. Unlike refined counterparts, WG consumption is inversely associated with risk of these gastrointestinal cancers, most consistently with the risk of colorectal tumor. Some WG effects may be mediated by beneficial constituents (such as fiber and polyphenols) that are reduced/lost during milling process. Beside health-promoting action, WGs are still under-consumed in most countries; therefore, World Health Organization and other public/private stakeholders should cooperate to implement WG consumption in the whole population, in order to reach nutritionally effective intakes.

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Risk factors for gastric precancerous and cancers lesions in Latin American counties with difference gastric cancer risk

Cited by 22 publications

References 45 publications

Cytokine TGF-β1, TNF-α, IFN-γ and IL‐6 Gene Polymorphisms and Localization of Premalignant Gastric Lesions in Immunohistochemically H. pylori-negative Patients

Cytokine TGF-β1, TNF-α, IFN-γ and IL‐6 Gene Polymorphisms and Localization of Premalignant Gastric Lesions in Immunohistochemically H. pylori-negative Patients

Establish a Scoring Model for High-Risk Population of Gastric Cancer and Study on the Pattern of Opportunistic Screening

The Impact of Whole Grain Intake on Gastrointestinal Tumors: A Focus on Colorectal, Gastric, and Esophageal Cancers

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