The Strategies of Natural Polysaccharide in Wound Healing

Abstract

Severe or chronic wounds related to diseases or serious incidents have received big attention from not only a scientific standpoint but also a business perspective. Therefore, an effective treatment to abridge the long-term hospitalization of severe wound becomes indispensable. Glycosaminoglycan (GAG), one of the extracellular matrix molecules produced by fibroblasts, participates in cell-cell and cell-matrix interactions, in cell proliferation and migration, and in cytokine and growth factor signaling associated with all phases of wound recovery. Natural polysaccharide, for example, calcium alginate, which consists of mainly differing ratios of d-mannuronic and l-guluronic acid and rich of calcium ions, has been demonstrated to functionalize the glycosaminoglycan activity during wound healing. Once the trigger of the underlying wound healing mechanisms was understood, it should be possible to find ways to enhance and resolve the wound healing process in the patient with conditions and may lead to the potential for treatment alternatives in the future clinical field.

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

“…Polysaccharides from marine organisms such as algae have been reported to have anti-inflammatory and neuroprotective effects, related to their antioxidant activity [11]. Furthermore, polysaccharides such as agar, alginates, and carrageenan, which are all obtained from macroalgae (seaweed), are used in drug formulation and drug delivery [12,13]. Polysaccharides are also used in the pharmaceutical and cosmetic industries and have nutraceutical applications due to their antioxidant activity.…”

Extraction, Characterization, and Structure of a Novel Heteropolysaccharide from Lepidium sativum and Its Effects on Wound Healing in Diabetic Rats

“…However, biopolymers are commonly limited by their poor mechanical properties. They are associated with synthetic polymers in order to enhance their mechanical properties [ 42 ].…”

ZnO-NPs embedded biodegradable thiolated bandage for postoperative surgical site infection: In vitro and in vivo evaluation

“…Mucoadhesion is not only confined to the adherence at the wound site and causing skin eruptions but also hydration is complementary for a mucoadhesive polymer to expand and to induce mobility in the polymer chains in order to enhance the interpenetration process between polymer and mucin. Further, the anionic glycosaminoglycan (GAG) in the extracellular matrix of the wound can electrostatically attract cationic TCS and ZnO-NPs, leading to better mucoadhesion and accumulation of ZnO-NPs [38]. Enhanced TCS-Alg-ZnO swelling permits a mechanical entanglement by exposing the bioadhesive sites for hydrogen bonding and/or electrostatic interaction between the TCS-Alg-ZnO and the mucus network [39].…”