The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes

Fujimaki, Junya; Sayama, Neo; Shiotani, Shigenobu; Suzuki, Takanori; Nonaka, Miki; Uezono, Yasuhito; Oyabu, Mamoru; Kamei, Yasutomi; Nukaya, Haruo; Wakabayashi, Keiji; Morita, Akihito; Miura, Shinji

doi:10.3390/nu14051023

Cited by 15 publications

(11 citation statements)

References 42 publications

(50 reference statements)

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“…High expression of IFI27 inhibited apoptosis, while lack of IFI27 promoted apoptosis. IFI27 is also involved in the transition from S phase to G2 phase in the cell cycle and affects the expression of VEGF-A, which is required to promote angiogenesis [37]. In addition, IFI27 is critical in the transcriptional response to COVID-19 infection [38].…”

Section: Discussionmentioning

confidence: 99%

Potential relationships between uveitis and COVID-19: a bioinformatic study based on CEO database

Chang

2023

Preprint

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Purpose Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a great impact on human survival and a great threat to public health in countries all over the world. The link between COVID-19 and ocular illness has received increasing attention due to SARS-CoV-2 infection can be transmitted through eye contact. Using bioinformatics methods, we sought to investigate the potential molecular mechanisms between uveitis and COVID-19, providing rationales and directions for further exploration. Methods Transcriptomic data of uveitis and COVID-19 patient blood samples were accessed from the Gene Expression Omnibus public database. Common differentially expressed genes were identified. Genetic Ontology analysis, Kyoto Encyclopedia of Genes and Genomes pathway analysis, Protein-Protein Interaction network analysis were performed on intersected genes. We screened 5 hub genes by using the maximum clustering centrality algorithm. The Least Absolute Shrinkage and Selection Operator regression analysis identified the potential biomarkers for uveitis and COVID-19. Finally, the expression level and diagnostic value of the biomarker in the two diseases were determined. Results 50 intersected genes were extracted from differential expression analysis in uveitis and COVID-19. These genes were functionally enriched in cytokine-mediated signaling pathway, vesicle lumen, receptor ligand activity. Through KEGG analysis, these genes were found to be involved in viral protein interaction with cytokine and cytokine receptor, and cytokine-cytokine receptor interaction. HORMAD1 was obtained by Least Absolute Shrinkage and Selection Operator regression analysis, which was high expression in both uveitis and COVID-19 when compared to controls. Receiver Operating Characteristic values and AUC statistics indicated that HORMAD1 had diagnostic value for uveitis and COVID-19. Conclusions Bioinformatic analysis predicts HORMAD1 involvement in etiology and therapeutic targets of uveitis and COVID-19. However, additional clinical trials and studies are needed to confirm the role of HORMAD1.

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Section: Discussionmentioning

confidence: 99%

Potential relationships between uveitis and COVID-19: a bioinformatic study based on CEO database

Chang

2023

Preprint

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“…Tomato is the second-most important fruit or vegetable after potato in the cuisine world. Tomatidine, an alkaloid present in the leaf of tomatoes, has been shown to be useful against gastric cancer via the regulation of interferon-stimulated genes (ISGa) [ 68 ]. Carotenoids present in tomatoes are strong antioxidants and thus help in preventing the damage caused to the DNA.…”

Section: Plant-based Food Componentsmentioning

confidence: 99%

Research Trend and Detailed Insights into the Molecular Mechanisms of Food Bioactive Compounds against Cancer: A Comprehensive Review with Special Emphasis on Probiotics

Agrawal

Srivastava

2022

Cancers

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In an attempt to find a potential cure for cancer, scientists have been probing the efficacy of the food we eat and its bioactive components. Over the decades, there has been an exponentially increasing trend of research correlating food and cancer. This review explains the molecular mechanisms by which bioactive food components exhibit anticancer effects in several cancer models. These bioactive compounds are mainly plant based or microbiome based. While plants remain the primary source of these phytochemicals, little is known about probiotics, i.e., microbiome sources, and their relationships with cancer. Thus, the molecular mechanisms underlying the anticancer effect of probiotics are discussed in this review. The principal mode of cell death for most food bioactives is found to be apoptosis. Principal oncogenic signaling axes such as Akt/PI3K, JAK/STAT, and NF-κB seem to be modulated due to these bioactives along with certain novel targets that provide a platform for further oncogenic research. It has been observed that probiotics have an immunomodulatory effect leading to their chemopreventive actions. Various foods exhibit better efficacy as complete extracts than their individual phytochemicals, indicating an orchestrated effect of the food components. Combining bioactive agents with available chemotherapies helps synergize the anticancer action of both to overcome drug resistance. Novel techniques to deliver bioactive agents enhance their therapeutic response. Such combinations and novel approaches are also discussed in this review. Notably, most of the food components that have been studied for cancer have shown their efficacy in vivo. This bolsters the claims of these studies and, thus, provides us with hope of discovering anticancer agents in the food that we eat.

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“…However, GAs from the Solanaceae family may have a cytotoxic effect on healthy cells as well as cancer cells. Furthermore, their aglycon parts also have anticancer effects ( da Silva et al, 2017 ; Shen et al, 2017 ; Akhtar et al, 2018 ; Gu et al, 2018 ; Fekry et al, 2019 ; Ahmad, 2019 ; Hsieh et al, 2020 ; Fujimaki et al, 2022 ; Yu et al, 2020 ). SN, CH, SS, SM, and TT show antitumor activity against various types of neoplasms.…”

Section: Toxicity Of Solanaceae Glycoalkaloidsmentioning

confidence: 99%

Anticancer activity of glycoalkaloids from Solanum plants: A review

2022

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Cancer is still one of the main causes of death worldwide. For this reason, new compounds that have chemotherapeutic potential have been identified. One such group of substances is Solanaceae glycoalkaloids (GAs). They are natural compounds produced by plants widely used in traditional medicine for healing many disorders. Among others, GAs exhibit significant antitumor properties, for example, a strong inhibitory effect on cancer cell growth. This activity can result in the induction of tumor cell apoptosis, which can occur via different molecular pathways. The molecular mechanisms of the action of GAs are the subject of intensive research, as improved understanding could lead to the development of new cancer therapies. The genetic basis for the formation of neoplasms are mutations in protooncogenes, suppressors, and apoptosis-controlling and repair genes; therefore, substances with antineoplastic properties may affect the levels of their expression or the levels of their expression products. Therapeutic compounds can be applied separately or in combination with other drugs to increase the efficiency of cancer therapy; they can act on the cell through various mechanisms at different stages of carcinogenesis, inducing the process of apoptosis, blocking cell proliferation and migration, and inhibiting angiogenesis. This review summarizes the newest studies on the anticancer properties of solanine (SN), chaconine (CH), solasonine (SS), solamargine (SM), tomatine (TT) and their extracts from Solanum plants.

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The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes

Cited by 15 publications

References 42 publications

Potential relationships between uveitis and COVID-19: a bioinformatic study based on CEO database

Potential relationships between uveitis and COVID-19: a bioinformatic study based on CEO database

Research Trend and Detailed Insights into the Molecular Mechanisms of Food Bioactive Compounds against Cancer: A Comprehensive Review with Special Emphasis on Probiotics

Anticancer activity of glycoalkaloids from Solanum plants: A review

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