The stereoisomerism of second generation anticoagulant rodenticides: a way to improve this class of molecules to meet the requirements of society?

Abstract

Second generation anticoagulant rodenticides (SGAR) are generally highly efficient for rodent management even towards warfarin-resistant rodents. Nevertheless, because of their long tissue-persistence, they are very associated with non-target exposure of wildlife and have been identified as 'Candidates for Substitution' by the European Union's competent authority. A promising way to reduce ecotoxicity issues associated to SGAR could be the improvement of SGAR based on their stereoisomery, and due to this improvement, positioning about SGAR might be reconsidered. © 2018 Society of Chemical Industry.

Asymptomatic Anticoagulant Rodenticide Exposure in Dogs and Cats—A French and Belgian Rural and Urban Areas Study

“…Observation of the diastereomeric ratios of SGARs residues may provide an answer. Indeed, each SGARs is a mixture of pair of cis and trans diastereomers with different biological properties ( Damin-Pernik et al, 2016 ; Lattard and Benoit, 2019 ). In fact, one diastereomer is systematically eliminated more rapidly than the other, at least in rats ( Damin-Pernik et al, 2017 ).…”

2019 – A year of continued growth

“…Production of safer anticoaglulant rotenticides by use of particular stereioisomers that are more toxic to rodents than non‐target vertebrates was covered . A mini‐review provided evidence to dispel the view that DEET is a mammalian neurotoxin .…”

“…Production of safer anticoaglulant rotenticides by use of particular stereioisomers that are more toxic to rodents than non-target vertebrates was covered. 35 A mini-review provided evidence to dispel the view that DEET is a mammalian neurotoxin. 36 Prospects were provided for producing propesticides that move into crops more readily, but once in the crops, are altered to become active pesticides with limited systemic properties, thus reducing residues in plant parts consumed by vertebrates or pollinators.…”

Applied research for optimized vertebrate management: 11th European Vertebrate Pest Management Conference

“…A novel approach to minimise non‐target risk is to compose products of particular stereo‐chemical variants (e.g., cis or trans isomers) of anticoagulant rodenticides because variants have highly diverse half life and hence more or less potential to cause adverse effects in non‐target species . If variants with low half life but sufficient efficacy can be identified, produced separately and used in bait one of the disadvantages of some anticoagulant compounds could be mitigated.…”