The Stemona Alkaloids

Abstract

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Phytochemical Studies on Stemona Plants: Isolation of New Tuberostemonine and Stemofoline Alkaloids

“…. The large positive specific optical rotation of 5 suggested it had the same absolute configuration of the A-D rings as (2'S)-hydroxystemofoline(1). To determine the absolute configuration of the 3'-hydroxyl group of 5 it was treated, in separate experiments, with (R)-(-)and (S)-(+)-Mosher's acid chloride ((R)-and (S)-αmethoxy-α-(trifluoromethyl)phenylacetyl chloride) to provide the corresponding (S)-and (R)-Mosher's esters, respectively.…”

TLC-Image Analysis of Non-Chromophoric Tuberostemonine Alkaloid Derivatives in Stemona Species

“…Natural Product Communications Vol. 8 (8) 2013 1067 Table 4: The contents of tuberostemonine (1), tuberostemonine A (2), tuberostemonine N (3), and neotuberostemonine (4) in dried powder of S. tuberosa and S. phyllantha roots collected from different locations in Thailand.…”

“…Stemona plants have been traditionally used as natural pesticides and medicinal plants for the treatment of skin and respiratory diseases in many Southeast Asian countries [1][2][3]. A recent taxonomic revision indicates that Stemona in Thailand comprises 11 species [4][5].…”

Ultra‐performance Liquid Chromatography–High‐definition Mass Spectrometry Analysis of Constituents in the Root of Radix Stemonae and those Absorbed in Blood after Oral Administration of the Extract of the Crude Drug

“…Radix Stemonae, first recorded in the herbal ‘ Additional Records of Famous Physicians ’ (Mingyi Bielu), has been widely used as an oral anti‐tussive agent in traditional Chinese medicine (TCM) for thousands of years with pharmacological effects as anti‐tussive, anti‐tuberculous, anti‐bacterial, anti‐fungal and anti‐helminthic (Pilli et al , ; Greger, ; Jiang et al , ). Three species of the Stemona genus ( S. tuberosa , S. japonica and S sessilifolia ) are officially listed in the Chinese Pharmacopoeia (CP, 2010 edn) as anti‐tussive TCM herbs.…”

“…tuberosa has the most superactive anti‐tussive effect among the three species (Hu et al , ), the present study focuses on S. tuberosa only. Species of Stemona contain interesting polycyclic alkaloids with an unusual molecular architecture bearing a pyrrolo‐ or a pyrido[1,2‐α]azepine nucleus (Kaltenegger et al , ; Pilli et al , ). The bioactive ingredients have been revealed to be Stemona alkaloids (Chung et al , ; Lin et al , , ; Xu et al , ), such as neotuberostemonine (Chung et al , ; Xu et al , ), tuberostemonine (Shinozaki and Ishida, ; Xu et al , ), stemoninine and croomine (Xu et al , ).…”