Introduction. The authors note insufficient knowledge of pathophysiological mechanisms, the cumulative role of cerebral functioning disorders in the formation of sensorineural deficit in vibration disease (VD). The study aims to identify changes in indicators characterizing neurofunctional activity in patients with VD due to the combined effects of local and general vibration. Materials and methods. The study involved 42 patients with VD (group I), 35 healthy men (comparison group). Researchers used methods of electroneuromyography, neuroenergic mapping, and neuropsychological testing. Results. In group I, when compared with the comparison group, we have detected an increase in latency N9, N10, N11, N13, N25, N30, the duration of the peak interval N10-N13 (p=0,002; 0,0001; 0,0002; 0,0001; 0,0023; 0,005; 0,01 respectively); an increase in local levels of constant potential (LCP) in the frontal, central, right parietal, occipital, right temporal parts of the brain (p=0.037; 0.0007; 0,0005; 0,01; 0,0004; 0,014; 0,029; 0,028; 0,001 respectively). Cognitive impairments in patients with VD correspond to an easily expressed disorder of analytical-synthetic and conceptual thinking, short-term (auditory-speech), visual imagery, long-term memory, dynamic praxis, joint coordination, impressive and expressive speech. The revealed conjugacy of the indicators of the LCP of the frontal left abduction, and the latency of the peak N30, duration N13-N20, and the hand of analytical and synthetic thinking (r=0.51, p=0.004; r=0.50, p=0.005, respectively) indicates the pathogenetic significance in the violation of neurofunctional activity of a decrease in cortical activation as a result of the arrival of a sensory message from the brain stem to the cortex, increased energy exchange in the frontal part of the left hemisphere. Conclusions. A sign of impaired neurofunctional activity in VB from the combined effects of local and general vibration is a decrease in the postsynaptic action of neurons, the time of signal passage through afferent pathways at the level of the cervical spinal cord, dynamic praxis, short-term (auditory-speech) memory, increased energy metabolism in the temporal right and left frontal brain.