The State of Oxidative Homeostasis in Children
With Influenza Stomatitis

Гевкалюк, Н. О.; Sydliaruk, Nataliya; Posolenyk, L. Ya.; Vydoinyk, Oksana Ya.; Kuchyrka, Lesia I.

doi:10.36740/wlek201903117

Cited by 3 publications

(4 citation statements)

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“…In control mice, after 3 days of infection, the oxidase activity increased approximately twofold. The results are in good agreement with data that show, during influenza infection, the holo-Cp level in the blood increases together with other acute phase proteins and remains high throughout the infection [37,66]. This fact indicates that the increase in Cp gene expression occurs at the transcriptional level.…”

Section: Discussionsupporting

confidence: 91%

Anti-Influenza Effect of Nanosilver in a Mouse Model

et al. 2020

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The present study assesses copper metabolism of the host organism as a target of antiviral strategy, basing on the “virocell” concept. Silver nanoparticles (AgNPs) were used as a specific active agent because they reduce the level of holo-ceruloplasmin, the main extracellular cuproenzyme. The mouse model of influenza virus A infection was used with two doses: 1 LD50 and 10 LD50. Three treatment regimens were used: Scheme 1—mice were pretreated 4 days before infection and then every day during infection development; Scheme 2—mice were pretreated four days before infection and on the day of virus infection; Scheme 3—virus infection and AgNP treatment started simultaneously, and mice were injected with AgNPs until the end of the experiment. The mice treated by Scheme 1 demonstrated significantly lower mortality, the protection index reached 60–70% at the end of the experiment, and mean lifespan was prolonged. In addition, the treatment of the animals with AgNPs resulted in normalization of the weight dynamics. Despite the amelioration of the infection, AgNP treatment did not influence influenza virus replication. The possibility of using nanosilver as an effective indirectly-acting antiviral drug is discussed.

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Section: Discussionsupporting

confidence: 91%

Anti-Influenza Effect of Nanosilver in a Mouse Model

et al. 2020

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“…Two studies found that during viral infection, serum hepcidin levels increased and iron levels decreased [ 169 , 170 ]. Blood plasma transferrin saturation by iron was significantly reduced in patients with severe forms of influenza stomatitis [ 171 ]. The mean hemoglobin level in infants and toddlers decreased with increasing numbers of infectious episodes [ 172 ].…”

Section: Resultsmentioning

confidence: 99%

“…In existing studies of viral infections and iron in children, decreased levels of serum hemoglobin, iron and plasma transferrin saturation were observed during infection [169][170][171][172]. The decrease in serum iron levels during infection may be due to increased hepcidin [311][312][313][314][315][316].…”

Section: Discussionmentioning

confidence: 99%

Dietary patterns and micronutrients in respiratory infections including COVID-19: a narrative review

Salehi,

Askari,

Jafari

et al. 2024

BMC Public Health

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Background COVID-19 is a pandemic caused by nCoV-2019, a new beta-coronavirus from Wuhan, China, that mainly affects the respiratory system and can be modulated by nutrition. Methods This review aims to summarize the current literature on the association between dietary intake and serum levels of micronutrients, malnutrition, and dietary patterns and respiratory infections, including flu, pneumonia, and acute respiratory syndrome, with a focus on COVID-19. We searched for relevant articles in various databases and selected those that met our inclusion criteria. Results Some studies suggest that dietary patterns, malnutrition, and certain nutrients such as vitamins D, E, A, iron, zinc, selenium, magnesium, omega-3 fatty acids, and fiber may have a significant role in preventing respiratory diseases, alleviating symptoms, and lowering mortality rates. However, the evidence is not consistent and conclusive, and more research is needed to clarify the mechanisms and the optimal doses of these dietary components. The impact of omega-3 and fiber on respiratory diseases has been mainly studied in children and adults, respectively, and few studies have examined the effect of dietary components on COVID-19 prevention, with a greater focus on vitamin D. Conclusion This review highlights the potential of nutrition as a modifiable factor in the prevention and management of respiratory infections and suggests some directions for future research. However, it also acknowledges the limitations of the existing literature, such as the heterogeneity of the study designs, populations, interventions, and outcomes, and the difficulty of isolating the effects of single nutrients from the complex interactions of the whole diet.

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“…As mentioned, the level of Cp in a patient’s blood serum rises several times and remains high during IAV infection [ 120 , 121 , 156 ]. This effect was viewed as a defensive response of the organism, and Cp was considered a potential nonspecific agent for prophylaxis and treatment of myxo- and paramyxovirus infections [ 118 ].…”

Section: The Points In Which Iav-induced Inflammation Cross With Copper Metabolismmentioning

confidence: 99%

The Crossroads between Host Copper Metabolism and Influenza Infection

Puchkova

Kiseleva

Polishchuk

et al. 2021

IJMS

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Three main approaches are used to combat severe viral respiratory infections. The first is preemptive vaccination that blocks infection. Weakened or dead viral particles, as well as genetic constructs carrying viral proteins or information about them, are used as an antigen. However, the viral genome is very evolutionary labile and changes continuously. Second, chemical agents are used during infection and inhibit the function of a number of viral proteins. However, these drugs lose their effectiveness because the virus can rapidly acquire resistance to them. The third is the search for points in the host metabolism the effect on which would suppress the replication of the virus but would not have a significant effect on the metabolism of the host. Here, we consider the possibility of using the copper metabolic system as a target to reduce the severity of influenza infection. This is facilitated by the fact that, in mammals, copper status can be rapidly reduced by silver nanoparticles and restored after their cancellation.

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The State of Oxidative Homeostasis in Children With Influenza Stomatitis

Cited by 3 publications

References 0 publications

Anti-Influenza Effect of Nanosilver in a Mouse Model

Anti-Influenza Effect of Nanosilver in a Mouse Model

Dietary patterns and micronutrients in respiratory infections including COVID-19: a narrative review

The Crossroads between Host Copper Metabolism and Influenza Infection

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