The stable aryl hydrocarbon receptor agonist potency of United Kingdom Continental Shelf (UKCS) offshore produced water effluents

Hurst, Mark R.; Chan-Man, Yin L.; Balaam, Jan; Thain, John E.; Thomas, Kevin V.

doi:10.1016/j.marpolbul.2005.07.009

Cited by 18 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bio-TEQ values of the influents and effluents from the two STPs in our study were lower than that of United Kingdom offshore produced water [48] but higher than that determined in Chinese STPs [4,10]. The lower Bio-TEQ values in Chinese STPs might be attributable to substrate inhibition in the ethoxyresorufin-O-deethylase assay, which can underestimate the potential of AhR agonists.…”

Section: Potential Of Wastewater On Ahr Transactivationcontrasting

confidence: 75%

Endocrine potency of wastewater: Contents of endocrine disrupting chemicals and effects measured by in vivo and in vitro assays

Kusk

Krüger

Long

et al. 2010

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Industrial and municipal effluents are important sources of endocrine disrupting compounds (EDCs) discharged into the aquatic environment. This study investigated the endocrine potency of wastewater and the cleaning efficiency of two typical urban Danish sewage treatment plants (STPs), using chemical analysis and a battery of bioassays. Influent samples, collected at the first STP grate, and effluent samples, collected after the sewage treatment, were extracted using solid phase extraction. Extracts were analyzed for the content of a range of industrial chemicals with endocrine disrupting properties: phthalate metabolites, parabens, industrial phenols, ultraviolet screens, and natural and synthetic steroid estrogens. The endocrine disrupting bioactivity and toxicity of the extracts were analyzed in cell culture assay for the potency to affect the function of the estrogen, androgen, aryl hydrocarbon, and thyroid receptors as well as the steroid hormone synthesis. The early-life stage (ELS) development was tested in a marine copepod. The concentrations of all analyzed chemicals were reduced in effluents compared with influents, and for some to below the detection limit. Influent as well as effluent samples from both STPs were found to interact with all four receptors and to interfere with the steroid hormone synthesis showing the presence of measured EDCs. Both influent samples and one of the effluent samples inhibited the development of the copepod Acartia tonsa. In conclusion, the presence of EDCs was reduced in the STPs but not eliminated, as verified by the applied bioassays that all responded to the extracts of effluent samples. Our data suggest that the wastewater treatment processes are not efficient enough to prevent contamination of environmental surface waters.

show abstract

Section: Potential Of Wastewater On Ahr Transactivationcontrasting

confidence: 75%

Endocrine potency of wastewater: Contents of endocrine disrupting chemicals and effects measured by in vivo and in vitro assays

Kusk

Krüger

Long

et al. 2010

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…Even waters from most major rivers in Tokyo have agonistic responses (7.1-31 ng/L BNF equivalents) in our recombinant yeast assay [14]. Substantially higher 2,3,7,8-tetrachrolodibenzo-p-dioxin equivalents (up to 436 ng/L) were reported in water effluents from offshore oil and gas platforms located on the North Sea continental shelf [39]. These values are all lower than the effective concentrations in the present in vivo experiments.…”

Section: à3mentioning

confidence: 67%

The feasibility of using mosquitofish (Gambusia affinis) for detecting endocrine‐disrupting chemicals in the freshwater environment

Kamata

Itoh

Nakajima

et al. 2011

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

We evaluated the utility of gene-transcriptional responses in the liver of mosquitofish (Gambusia affinis), a species introduced to many countries and therefore widely available, for detecting endocrine-disrupting activity in water. Exposure to β-naphthoflavone, an aryl hydrocarbon receptor (AhR) agonist, significantly increased the transcript of the cytochrome P4501A gene (cyp1a), peaking at 24 h, in both sexes at concentrations of 10 µg/L or more. 17β-Estradiol (E(2) ) at 500 ng/L increased the number of males showing gene transcription of precursors of yolk protein, vitellogenin (Vtga, Vtgb, and Vtgc), at 24, 48, and 72 h. Exposure for 48 h to bisphenol A (BPA), an estrogen mimic, also increased vtg-positive males at 1 mg/L or more. Leachate from a Japanese stable-type landfill significantly increased vtg-positive males after 48 h exposure, and the in vitro activity of the leachate against the estrogen receptor (ER) was estimated as an E(2) equivalent of 240 ng/L by yeast transfected with the ER. Chemical analysis showed that major contributors to the ER activation were BPA and 4-tert-octylphenol. This leachate and drainage water from a control-type landfill had AhR activities, estimated by yeast with the AhR, but had no significant effect on cyp1a transcription. These results showed that mosquitofish are suitable for detecting in vivo AhR and ER effects, but are insensitive to E(2).

show abstract

“…Compared with HRGC/HRMS, CALUX bioassay is a rapid and low-cost screening method particularly for fast-screen identification of highly dioxin-contaminated samples from environment and food. Recently, the CALUX bioassay has been used in detection of the levels of dioxin-TEQ in both biota [9,10] and environment [11,12] in some developed countries. The CALUX bioassay has been certified a new method for detecting dioxins in Japan in September 2005.…”

Section: Introductionmentioning

confidence: 99%

Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells

Chao

Tsou

et al. 2006

Journal of Hazardous Materials

View full text Add to dashboard Cite

The stable aryl hydrocarbon receptor agonist potency of United Kingdom Continental Shelf (UKCS) offshore produced water effluents

Cited by 18 publications

References 10 publications

Endocrine potency of wastewater: Contents of endocrine disrupting chemicals and effects measured by in vivo and in vitro assays

Endocrine potency of wastewater: Contents of endocrine disrupting chemicals and effects measured by in vivo and in vitro assays

The feasibility of using mosquitofish (Gambusia affinis) for detecting endocrine‐disrupting chemicals in the freshwater environment

Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells

Contact Info

Product

Resources

About