The stabilization of parenteral fat emulsion using non-ionic ABA copolymer surfactant

Jumaa, Muhannad; Müller, Bernd W.

doi:10.1016/s0378-5173(98)00222-1

Cited by 34 publications

(18 citation statements)

References 19 publications

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“…Chitosan impart a positive charge in the formulation due to the presence of amino groups which results in reversal of charge in formulations. Similar behavior was also observed by the group of Jumaa and Muller (1998b). However, further addition of chitosan resulted in unstable formulation.…”

Section: Resultssupporting

confidence: 86%

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Ciprofloxacin surf-plexes in sub-micron emulsions: A novel approach to improve payload efficiency and antimicrobial efficacy

Jain

Singodia

Gupta

et al. 2011

International Journal of Pharmaceutics

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Section: Resultssupporting

confidence: 86%

“…PF-68 is mandatory to get stable formulation as it is known to prevent unfavorable interactions between free fatty acids present in soya oil and cationic agents. It has been reported (Jumaa and Muller, 1998b) that PF-68 in optimized concentration is necessary to obtain a chitosan emulsion with sufficient stability.…”

Section: Resultsmentioning

confidence: 97%

Ciprofloxacin surf-plexes in sub-micron emulsions: A novel approach to improve payload efficiency and antimicrobial efficacy

Jain

Singodia

Gupta

et al. 2011

International Journal of Pharmaceutics

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“…This observation may be attributed to the fact that phospholipids being highly soluble in oil phase are not sufficiently available at the oil-water interface to impart stability. Interestingly, the stability was significantly improved on addition of hydrophilic co-emulsifier (Pluronic F-68) which could have rendered interfacial film stronger to prevent globule coalescence during physical and thermal process and due to strong steric repulsion (Jumaa and Muller 1998b). Moreover, Pluronic F-68 is known to prevent unfavorable interactions between free fatty acids present in oil phase and cationic agents.…”

Section: Resultsmentioning

confidence: 99%

Preparation and performance evaluation of saquinavir laden cationic submicron emulsions

et al. 2009

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“…This might be due to the low cloud point of Tween80. It had been established previously that emulsion formulations, containing an emulsifier with a high cloud point, were more resistant to coalescence during the autoclaving process, while formulations with a low cloud point, precipitated at the sterilization temperature leading to a breakdown of the film around the oil droplets and the coalescence of the droplets 14. In addition, Jumaa et al 15 reported that LM with only Tween80 as an emulsifier showed a remarkable erythrocyte membrane damage, but the formulations using only S75 and F68 did not.…”

Section: Resultsmentioning

confidence: 99%

Formulation, preparation, and stability of intravenous bufadienolides‐loaded lipid microspheres

Weng

Cheng

Meng

et al. 2012

Euro J Lipid Sci & Tech

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The purpose of this study was to develop a new formulation of intravenous lipid microspheres for bufadienolides (bufadienolides-loaded lipid microspheres, BU-LM) and investigate the stability of BU-LM after dilution and long-term storage. Photon correlation spectroscopy, electrophoretic light scattering, and light microscopy were used to evaluate the physical characteristics of BU-LM. The chemical properties of bufadienolides were measured by high-performance liquid chromatography. The optimum BU-LM, consisting of 10% MCT, 3.0% Lipoid S75, 0.4% F68, 0.05% sodium oleate and 2.5% glycerol, was prepared by emulsification with a high-speed shear mixing at 10 000 rpm for 12 min and a high-pressure homogenization at 800 bar for 8 cycles at 308C. The BU-LM at pH 6.48, with the particle size distribution of 175.2 AE 57.3 nm, z-potential of À32.10 mV, entrapment efficiency of 86.9%, 91.7%, 92.9%, and contents of 20.8%, 31.3%, 50.4% for B, C, R, respectively, was stable after sterilization in a 1218C rotating autoclave water steam bath for 10 min. Moreover, BU-LM had sufficient physicochemical stability after dilution with 5% glucose injection and long-term storage at 4 AE 28C for 18 months. BU-LM has a great potential for clinical applications as a new drug delivery system for bufadienolides.Practical applications: Bufadienolides, mainly composed of bufalin (B), cinobufagin (C), and resibufogenin (R) have poor aqueous solubility and are chemically unstable. Currently the main marketable products of bufadienolides are solution injections, which cause serious venous irritation and in this formulation, the drug is not protected from degradation. Lipid microspheres, with the unique properties of a low cost, low toxicity, good storage stability, easy to scale up production, sustained release and targeting effect, incorporate the drugs into the interior oil phase and the oil-water interfacial film; thus a direct contact of the drug with body fluids and tissues is prevented, which increases the stability of the drugs and minimizes the possible side effects.

show abstract

The stabilization of parenteral fat emulsion using non-ionic ABA copolymer surfactant

Cited by 34 publications

References 19 publications

Ciprofloxacin surf-plexes in sub-micron emulsions: A novel approach to improve payload efficiency and antimicrobial efficacy

Ciprofloxacin surf-plexes in sub-micron emulsions: A novel approach to improve payload efficiency and antimicrobial efficacy

Preparation and performance evaluation of saquinavir laden cationic submicron emulsions

Formulation, preparation, and stability of intravenous bufadienolides‐loaded lipid microspheres

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