The Stability of Dentin Surface Biobarrier Consisting of Mesoporous Delivery System on Dentinal Tubule Occlusion and Streptococcus Mutans Biofilm Inhibition

Epigallocatechin-3-gallate/mineralization precursors co-delivery hollow mesoporous nanosystem for synergistic manipulation of dentin exposure

“…Over the past decades, mesoporous silica nanoparticles featured by large surface area and pore volume, ordered framework, and chemical/thermal stability have been extensively used as enzyme, protein, gene, and drug delivery nanocarriers [ 28 , 29 ]. Due to its favorable mechanical and acid-resistant performance, mesoporous silica has been shown to be effective in tubule sealing by our previous studies [ 30 , 31 ]. Hollow mesoporous silica (HMS) attracts intense attention on account of its unique incorporation of a mesoporous shell and a hollow core [ 32 , 33 ].…”

The durability of resin–dentine bonds are enhanced by epigallocatechin‐3‐gallate‐encapsulated nanohydroxyapatite/mesoporous silica

“…Mesoporous silica nanoparticles (MSN) have a large surface area to accommodate more nanoparticles as well as excellent adsorption performance [ 18 , 19 , 20 ]; they have been extensively applied in the biomedicine domain. MSN has an obvious advantage as a carrier for delivering functional nanoparticles, such as drugs and genes [ 21 , 22 , 23 ]. Epigallocatechin gallate‐encapsulated nanohydroxyapatite/mesoporous silica (EGCG@nHAp@MSN) was synthesized to block dentin tubules and reduce dentin hypersensitivity [ 24 , 25 ].…”

Biomineralization-inspired sandwich dentin desensitization strategy based on multifunctional nanocomposite with yolk–shell structure

“…However, plugging in this study was noticeably stronger than that in previous studies. 28,29 This result was primarily attributable to the core of the PSTZ nanocomposite, which was composed of silica with strong acid resistance. Also, after mechanical brushing challenge, tubules were blocked more tightly owing to the vertical force (Fig.…”

“…Dentin permeability assessment was conducted by a modified fluid permeation device, as described in prior work. 28 To replicate pulp pressure, a fluid container filled with deionized water was positioned 50 cm above the test bench and connected to a capillary tube through a three-way connector. A 10 mL syringe was linked to the three-way connector via a polyethylene hose, which was used to make air bubbles indicating liquid movement.…”

“…Unfortunately, due to the hydrolysis of MSNs and the lack of new substances to fill the voids left after degradation, the long-term effect of DT occlusion showed a downward trend. 28,29 Thus, more superior carriers for mineralization precursors are still required. As inert elements, titanium and zirconium are stable in biological environments.…”