The spread of Tembusu virus in China from 2010 to 2019

Qiu, Guiru; Cui, Yongqiu; Li, Yeqiu; Wang, Yong

doi:10.1016/j.virusres.2021.198374

Cited by 13 publications

(7 citation statements)

References 48 publications

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“…TMUV can cause severe egg drop syndrome in infected ducks, which exhibit many clinical symptoms including lack of energy, decreased appetite, and elevated body temperature. The morbidity rate of infected ducks can reach 80-90%, and the mortality rate can reach 10-30% [13,14]. Researchers have found that TMUV can infect not only ducks but other avian species, including chickens, geese, pigeons, and sparrows, suggesting that TMUV has a wide host range.…”

Section: Introductionmentioning

confidence: 99%

The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus

Cui

Pan

Guo

et al. 2022

Viruses

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Tembusu virus (TMUV) can induce severe egg drop syndrome in ducks, causing significant economic losses. In this study, the possible origin, genomic epidemiology, and transmission dynamics of TMUV were determined. The time to the most recent common ancestor of TMUV was found to be 1924, earlier than that previously reported. The effective population size of TMUV increased rapidly from 2010 to 2013 and was associated with the diversification of different TMUV clusters. TMUV was classified into three clusters (clusters 1, 2, and 3) based on the envelope (E) protein. Subcluster 2.2, within cluster 2, is the most prevalent, and the occurrence of these mutations is accompanied by changes in the virulence and infectivity of the virus. Two positive selections on codons located in the NS3 and NS5 genes (591 of NS3 and 883 of NS5) were identified, which might have caused changes in the ability of the virus to replicate. Based on phylogeographic analysis, Malaysia was the most likely country of origin for TMUV, while Shandong Province was the earliest province of origin in China. This study has important implications for understanding TMUV and provides suggestions for its prevention and control.

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Section: Introductionmentioning

confidence: 99%

The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus

Cui

Pan

Guo

et al. 2022

Viruses

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“…In 2010, for the first time, TMUV was reported in China and caused an outbreak in egg-laying ducks [ 23 ]. TMUV was then regularly observed in China during the last decade, and a pattern of exclusive spreading in China was recently proposed [ 31 ]. Most strains isolated in China and Thailand during the last decade form a clade named Cluster 2.…”

Section: Tembusu Virusmentioning

confidence: 99%

“…Interestingly, the majority of strains isolated in Thailand since 2010 and a few strains from China belong to Cluster 2.a, whereas only isolates originating from China are grouped in Cluster 2.b ( Figure 2 ). Recently, two different research teams identified a novel cluster in the TMUV group named Cluster 3 [ 31 , 32 ]. Based on our phylogenetic analysis ( Figure 2 ), we also described this Cluster 3 which gathered only viral isolates from Thailand and China.…”

Section: Tembusu Virusmentioning

confidence: 99%

New Insights into the Biology of the Emerging Tembusu Virus

et al. 2021

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Reported for the first time in 1955 in Malaysia, Tembusu virus (TMUV) remained, for a long time, in the shadow of flaviviruses with human health importance such as dengue virus or Japanese encephalitis virus. However, since 2010 and the first large epidemic in duck farms in China, the threat of its emergence on a large scale in Asia or even its spillover into the human population is becoming more and more significant. This review aims to report current knowledge on TMUV from viral particle organization to the development of specific vaccines and therapeutics, with a particular focus on host–virus interactions.

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“…It also plays a crucial role in mediating virus receptor binding and virus cell membrane fusion and frequently undergoes genetic mutations under the evolutionary pressure of the host immune system [ 19 ]. TMUV strains are currently divided into 3 clusters (Cluster 1, 2, and 3) based on phylogenetic analysis of the open reading frame (ORF) region and the E gene [ 20 , 21 ]. Cluster 2 is currently the dominant cluster in China and Cluster 3 encompasses the majority of mosquito-derived isolates [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Persistence of Tembusu Virus in Culex tritaeniorhynchus in Yunnan Province, China

Wang

et al. 2023

Pathogens

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The Tembusu virus (TMUV), a member of the Flaviviridae family, can be transmitted via mosquitoes and cause poultry disease. In 2020, a strain of TMUV (YN2020-20) was isolated from mosquito samples collected in Yunnan province, China. In vitro experiments showed that TMUV-YN2020-20 produced a significant cytopathic effect (CPE) in BHK, DF-1, and VERO cells, while the CPE in C6/36 cells was not significant. Phylogenetic analysis revealed that the strain belonged to Cluster 3.2 and was closely related to the Yunnan mosquito-derived isolates obtained in 2012 and the Shandong avian-derived isolate obtained in 2014. Notably, TMUV-YN2020-20 developed five novel mutations (E-V358I, NS1-Y/F/I113L, NS4A-T/A89V, NS4B-D/E/N/C22S, and NS5-E638G) at loci that were relatively conserved previously. The results of this study demonstrate the continuous circulation and unique evolution of TMUV in mosquitoes in Yunnan province and suggest that appropriate surveillance should be taken.

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The spread of Tembusu virus in China from 2010 to 2019

Cited by 13 publications

References 48 publications

The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus

The Evolution, Genomic Epidemiology, and Transmission Dynamics of Tembusu Virus

New Insights into the Biology of the Emerging Tembusu Virus

Persistence of Tembusu Virus in Culex tritaeniorhynchus in Yunnan Province, China

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