The spread of carbapenemase-producing bacteria in Africa: a systematic review

Abstract

Carbapenemase-producing bacteria have been described in many African countries; however, their prevalence is poorly defined and has not been systematically studied. Antibiotic stewardship and surveillance systems, including molecular detection and genotyping of resistant isolates, should be implemented to monitor and reduce the spread of carbapenemase-producing bacteria.

Five-Year Antimicrobial Susceptibility Trends Among Bacterial Isolates from a Tertiary Health-Care Facility in Kigali, Rwanda

“…20 A review of published studies from Africa shows that the prevalence of carbapenemase-producing bacteria isolated in hospitals ranges from 9% to 60% in the sub-Saharan region. 21 Mushi and others reported on the prevalence of carbapenemase genes among MDR gram-negative bacilli from a tertiary hospital in Mwanza, Tanzania. They found that 35% of 227 isolates had at least one carbapenemase gene with Klebsiella pneumoniae (11%), Pseudomonas aeruginosa (10%), and E. coli (8%) being the most prevalent.…”

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care

“…4 Although little information about resistance patterns is available, the use of cephalosporins is high in Sierra Leone, 8 and reports have shown the presence of extended spectrum β-lactamase resistance (Grünewald T, unpublished data). 9 Hence, we started treatment with imipenem-cilastatin on admission. The patient developed a paralytic ileus accompanied by intestinal oedema, and a three-layered gallbladder with pericystic oedema, all representing sources of bacterial translocation.…”

First Description of IncX3 Plasmids Carrying bla OXA-181 in Escherichia coli Clinical Isolates in Burkina Faso

“…The few studies available on CPE epidemiology in West and East Africa highlight the identification of carbapenemases in Cameroon (NDM-4), Kenya (NDM-1), Sierra Leone (VIM and DIM-1), Senegal (OXA-48), and Tanzania (KPC, IMP, OXA-48, VIM, and NDM) (1). Although bla genes are widely spread in North Africa, bla OXA-48 derivatives have been rarely reported in Africa.…”