The spleen size in patients undergoing hemodialysis

Abstract

Introduction: Inflammation promotes the progression of chronic renal failure, and the start of dialysis worsens inflammation. The enlargement of the spleen is associated with inflammation, and patients on hemodialysis may show a large spleen. The aim of the present study was to compare the spleen size of patients undergoing hemodialysis versus controls to update this thread. Methods: Controls and patients were eligible to participate in the study provided they were negative for serological markers of hepatitis B and C viruses and HIV, if they had no lymphoproliferative disorder, and if they were at least 18 years of age. Age, sex, and the duration of dialysis were recorded. Laboratory variables (hemoglobin, hematological cell count, serum creatinine) and the underlying cause of end-stage renal disease were analyzed. The spleen sizes of the patients were divided into tertiles. Results: The 75 controls and 168 patients selected were sex-matched. The patients were older, had larger spleens and lower platelet counts than controls. The relationship between spleen size and age in the controls and patients was quite similar. The patients in the first tertile of spleen size compared with those in the third were older and had a higher platelet counts. The underlying disease and dialysis vintage had no effect on spleen size. Discussion: The patients had larger spleens and a greater range of spleen sizes than the controls. In patients, the association between larger and smaller spleen with lower and higher platelet counts, respectively, sparked the speculation of occurrence of hypersplenism and hyposplenism.

Transcranial sonography depicts a larger substantia nigra echogenic area in renal transplant patients on calcineurin inhibitors than on rapamycin

“…Moreover, the direct correlation between spleen size and SN echogenic area in RTRs, seen in this study, suggests that this finding may have similar underlying mechanisms. There is evidence supporting the role of inflammation in spleen enlargement commonly found in CKD [ 57 ]. This finding changed the study focus, as it was not designed to search for differences in SN echogenic area between different immunosuppressive regimens.…”

Deciphering the Molecular Mechanism of Yifei-Sanjie Pill in Cancer-Related Fatigue

“…YFSJ treatment can effectively reduce the level of proinflammatory factors in serum, thereby reducing the degree of inflammatory infiltration of muscle cells. At the same time, the size of the spleen can also reflect the level of inflammation in vivo to a certain extent [ 30 ]. We also found that the spleen of mice was significantly enlarged after tumor cell inoculation and decreased after high-dose YFSJ treatment compared with the CRF group.…”