The spectrum of neuropsychiatric abnormalities associated with electrical status epilepticus in sleep

Galanopoulou, Aristea S.; Bojko, Aviva; Lado, Fred A.; Moshé, Solomon L.

doi:10.1016/s0387-7604(00)00127-3

Cited by 166 publications

(162 citation statements)

References 62 publications

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“…In the work by Praline et al (2003), this correlation was not confirmed, but the small size of their sample involved to prevent any general conclusions from being drawn. As a whole, these data are similar to those reported in the review of Galanopoulou et al (2000) that reported a poor prognosis in half of the cases. Treatment for CSWS aims to reverse the ESES pattern of the EEG.…”

Section: Relationship Between Neuropsychological Data and Clinical Fesupporting

confidence: 90%

Frontal Lobe Epilepsies: Neuropsychological and Behavioral Consequences in Children

Vago¹,

Bulgheroni²,

Franceschetti³

et al. 2011

Epilepsy in Children - Clinical and Social Aspects

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Section: Relationship Between Neuropsychological Data and Clinical Fesupporting

confidence: 90%

Frontal Lobe Epilepsies: Neuropsychological and Behavioral Consequences in Children

Vago¹,

Bulgheroni²,

Franceschetti³

et al. 2011

Epilepsy in Children - Clinical and Social Aspects

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“…For example, infantile spasms may respond to hormonal therapy (adrenocorticotropic hormone [ACTH] or high‐dose corticosteroids) or vigabatrin but not to most of the classical antiseizure drugs. Epileptic encephalopathies (Landau‐Kleffner syndrome, continuous spike wave in slow wave sleep) may respond to hormonal therapy, whereas seizures in Dravet syndrome can be exacerbated by sodium channel blockers 20, 21, 22, 23. The neurobiology of the very young brain is very different from that in older age groups; consequently, age‐ and sex‐specific effects, efficacy, and tolerability of tested drugs cannot be predicted by the effects in older subjects 24, 25, 26.…”

Section: What Have Preclinical Drug Trials In Epilepsy Delivered? Unmmentioning

confidence: 99%

Not all that glitters is gold: A guide to critical appraisal of animal drug trials in epilepsy

Galanopoulou

Mowrey

2016

Epilepsia Open

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SummaryPreclinical studies have produced numerous drugs with antiseizure properties that currently are the standard of care. One third of the human population with epilepsy still continues to have seizures despite the ongoing discoveries. The recognized clinical gaps of care that need to be addressed are the identification of antiepileptogenic and disease‐modifying treatments, and treatments for refractory seizures or for seizures and epilepsies with limited or unsatisfactory treatments, such as early life epileptic encephalopathies. In this invited review, we provide a historical summary of the international efforts to reevaluate the strategies adopted in preclinical epilepsy therapy discovery studies. We discuss issues that may affect the quality, interpretation, and validation of preclinical studies and their translation to successful therapies for humans affected with epilepsy. These include the selection of animal models and the study design; research practices that affect rigor (such as appropriate use of statistics and reporting of study methods and results, their validation across models, labs, and preclinical‐clinical studies); the need to harmonize research methods and outcome assessment; and the importance of improving translation to clinically appropriate situations. The epilepsy research community is incrementally adopting collaborative research, including consortia or multicenter studies to meet these needs. Improving the infrastructure that can support these efforts will be instrumental in future success.

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“…Характерно наличие выраженного дефицита внимания (обычно в сочетании с гиперактивностью), быстрой истощае-мости, проявлений психического инфантилизма [8]. Примерно у 25 % пациентов возникают серьезные нарушения поведения по типу аутистико-, психопа-то-или шизофреноподобного синдромов [37]. Пси-хические нарушения в целом констатируются у 81 % больных ЭЭСМ (тревога, депрессия, импульсивность, фрустративность, стремление к разрушению и др.…”

Section: Ch I Ld Neurology R U S S I a N J O U R N A L O Funclassified

The Formation of Cognitive and Mental Disorders in Epilepsy: The Role of Various Factors Associated With Disease and Treatment (A Review of Literature and Case Reports)

Мухин¹,

Пылаева²

2017

Rus. ž. det. nevrol.

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The spectrum of neuropsychiatric abnormalities associated with electrical status epilepticus in sleep

Cited by 166 publications

References 62 publications

Frontal Lobe Epilepsies: Neuropsychological and Behavioral Consequences in Children

Frontal Lobe Epilepsies: Neuropsychological and Behavioral Consequences in Children

Not all that glitters is gold: A guide to critical appraisal of animal drug trials in epilepsy

The Formation of Cognitive and Mental Disorders in Epilepsy: The Role of Various Factors Associated With Disease and Treatment (A Review of Literature and Case Reports)

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