The Spectrum of Long‐term Epilepsy–associated Tumors: Long‐term Seizure and Tumor Outcome and Neurosurgical Aspects

Abstract

Tumors associated with long-term epilepsy should be removed early for two different reasons: high rate of seizure freedom and rare but potential risk of malignant tumor progression. The unexpected long survival of these astrocytomas should be investigated by using immunohistochemistry and molecular biology.

Long‐term surgical outcomes of temporal lobe epilepsy associated with low‐grade brain tumors

“…The stable maintenance of seizure outcome in tumor-related epilepsy patients has been reported in another study. 4 This stability is in contrast with the steady decline in seizure control rates after surgery for MTS.…”

“…Although some authors reported that good seizure control can be obtained despite incomplete tumor resection, 11,12 the importance of total tumor removal for seizure control has been emphasized by many authors, especially in recent studies. 4,5,13 However, Daumas-Duport et al 14 reported…”

“…Moreover, a patient died of relentless recurrence and malignant transformation of low-grade ganglioglioma after intended subtotal resection for protection of memory function. Although it has been proposed that brain tumors presenting with chronic epilepsy are biologically indolent, 4,15 to the best of our knowledge, the prognosis cannot yet be predicted on a patient basis, and total tumor removal has an important meaning in the oncological perspective.…”

Epilepsy Related to Developmental Tumors and Malformations of Cortical Development

“…In recent years, the concept of long-term epilepsy associated tumors (LEAT) has been introduced [4,7]. LEAT are low grade, slowly growing, cortically-based tumors, often with a temporal lobe localization.…”

Neurosurgical Management of Intractable Temporal Lobe Epilepsy by Amygdalohippocampectomy Plus Anterior Temporal Lobectomy: Report of Initial Three Pediatric Cases with Short Literature Review

“…Seizure control rate in MTS after surgery is excellent 2,3 . Certain types of low-grade gliomas (e.g., isomorphic subtype of low-grade astrocytoma, pilocytic astrocytoma) causing intractable epilepsy can be operated on with excellent results 13,14,15,16 . In a series limited to preoperatively tailored resections for lesional (nonsclerotic) mesial TLE, satisfactory seizure control was obtained in 86% of patients 17 .…”