Long‐term surgical outcomes of temporal lobe epilepsy associated with low‐grade brain tumors

Abstract

BACKGROUND: Tumor-related temporal lobe epilepsy (TLE) has a high likelihood of medical intractability and requires surgical treatment. The aims of this study were to analyze the long-term surgical outcomes of

Evaluation of Focal Cortical Dysplasia and Mixed Neuronal and Glial Tumors in Pediatric Epilepsy Patients Using18F-FDG and11C-Methionine PET

“…Because MNGTs are frequently associated with FCD in the adjacent cortex, it remains controversial whether extensive invasive electroencephalography monitoring and cortical resection are required for patients with these tumors (21)(22)(23). Nonetheless, recent studies on tumor-related chronic epilepsy emphasize that complete removal of the tumor itself is the most important prognostic factor for seizure control (7,8,23). The prognosis of tumor-related epilepsy is excellent, with seizure-free rates approaching 80% (4,8).…”

“…Nonetheless, recent studies on tumor-related chronic epilepsy emphasize that complete removal of the tumor itself is the most important prognostic factor for seizure control (7,8,23). The prognosis of tumor-related epilepsy is excellent, with seizure-free rates approaching 80% (4,8). Therefore, surgical strategies and outcome expectation could be deeply influenced by the presurgical imaging diagnosis of the lesion.…”

“…The wide histologic spectrum of DNTs remains poorly understood, and gangliogliomas exhibit diverse features, from a welldifferentiated tumor to an anaplastic variant (19). Although it has long been held that DNTs do not recur, even after incomplete resection (24), recurrence and progression of some DNTs have been reported (8,25). The clinical behavior of gangliogliomas is also unpredictable, with malignant progression occurring in some patients (26,27).…”

“…In the case of FCD, wide cortical resection over the MRI-delineated lesion using invasive electroencephalography is frequently recommended for adequate seizure control, because the histologic boundaries of FCD are not clear in many cases (6). In contrast, recent studies on tumor-associated epilepsy emphasize that total resection of the tumor is sufficient for seizure control in many patients (7,8). Second, the outcome and prognosis after surgery vary significantly between these diseases.…”

“…Second, the outcome and prognosis after surgery vary significantly between these diseases. The seizure-free rates after surgery are reportedly around 70%280% for tumor-associated epilepsy (4,8), whereas the seizure-free rates after surgery for FCD, for all surgical techniques, fall around 40%250% (2,9).…”