The Spectrum of Laryngeal Neoplasia: The Pathologist's View

Koren, Rumelia; Kristt, Donald A.; Shvero, Jakob; Yaniv, Eitan; Dekel, Yoram; Gal, Rivka

doi:10.1078/0344-0338-00325

Cited by 21 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Molecular markers are subject of investigation: in spite of many studies, the molecular events that induce the development of premalignancies to carcinoma are still unknown, and we are still forced to conclude that over (or under)-expression of biomarkers itself adds little predictive value over standard histology . [ 62 - 66 ] Therefore, until now they are not applicable in clinical practice. [ 67 ]…”

Section: Prognostic and Predictive Valuementioning

confidence: 99%

Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility

Fleskens¹,

Slootweg

2009

Head Neck Oncol

100

View full text Add to dashboard Cite

BackgroundGrading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed.ObjectivesThe aims of this review are to:1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck.2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck.3) Discuss and review quality requirements for these grading systems.ConclusionRegarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck.

show abstract

Section: Prognostic and Predictive Valuementioning

confidence: 99%

Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility

Fleskens¹,

Slootweg

2009

Head Neck Oncol

100

View full text Add to dashboard Cite

show abstract

“…The criteria for histological grading were additionally formulated by a Working Group on Head and Neck Pathology of the European Society of Pathology in 1997 [51]. The Ljubljana system nominally recognizes four grades: simple hyperplasia and basal/parabasal cell hyperplasia include mainly benign categories with a minimum risk of malignant alteration; atypical hyperplasia is potentially a malignant lesion; CIS is actually a malignant lesion [50,[57][58][59][60][61]. The main features that differentiate the Ljubljana grading system from other classifications are the distinction between mainly benign (squamous hyperplasia and basal-parabasal hyperplasia) and potentially malignant (atypical hyperplasia) lesions, and the positive separation of CIS from atypical hyperplasia.…”

Section: Ljubljana Classification and Sil Classificationmentioning

confidence: 99%

Oral premalignant lesions: from the pathological viewpoint

Izumo

2011

Int J Clin Oncol

View full text Add to dashboard Cite

Under the widely used World Health Organization (WHO) classification for the pathological diagnosis of oral premalignant lesions, dysplasia, which is graded as mild, moderate or severe, and carcinoma in situ (CIS), which is a non-invasive carcinoma, are classified as precursor lesions of oral squamous cell carcinoma. Since the first edition (Wahi et al. International histological classification of tumours no. 4, WHO, Geneva, 1971), the criterion for CIS--that all epithelial layers are replaced by atypical cells--has remained unchanged. However, this dysplasia-carcinoma sequence theory was introduced from the viewpoint of pathological changes in the uterine cervix: in contrast, almost all premalignant lesions and CIS of the oral mucosa show superficial maturation and differentiation. Based on this recognition, the squamous intraepithelial neoplasia (SIN) classification and Ljubljana classification were included in WHO's latest edition published in 2005. Although the WHO classification is commonly used in Japan, recent developments in oral oncology have promoted modifications of the classification used in this country. In 2005, the Working Group of the Japan Society for Oral Tumours advocated iodine staining and proposed a modified SIN system, and in 2007, the Working Committee of the Japanese Society for Oral Pathology (JSOP) reported a new CIS (JSOP) definition that included differentiated-type CIS. In 2010, based on these studies, a new entity--oral intraepithelial neoplasia (OIN)--was included in the first edition of General Rules for Clinical and Pathological Studies on Oral Cancer. In this review, we focus on the OIN/CIS (JSOP) new classification of premalignant lesions in oral mucosa, which further advances the concept of SIN.

show abstract

“…Squamous cell carcinoma is the most common histological type of laryngeal malignancy. It accounts for more than 90 % of laryngeal cancers in most studies (1,2). Most patients are 50 to 75 years of age at presentation.…”

mentioning

confidence: 99%

Risk Factors for Laryngeal Cancer in Montenegro

Zvrko

Gledović

Ljaljević³

2008

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Laryngeal cancer is the most common head and neck cancer. There might be many risk factors for laryngeal cancer. Smoking, especially cigarette smoking and alcohol are indisputable risk factors. The authors of this paper assessed the presumed risk factors in order to identify possible aetiological agents of the disease. A hospital-based case-control study was conducted. The study group consisted of 108 histologically verified laryngeal cancer patients and 108 hospital controls matched by sex, age (±3 years) and place of residence. Laryngeal cancer patients and controls were interviewed during their hospital stay using a structured questionnaire. According to multiple logistic regression analysis six variables were independently related to laryngeal cancer: hard liquor consumption (Odd Ratio /OR/=2.93, Confidence Interval /CI/ 95 % = 1.17 to 7.31), consumption more than 2 alcoholic drinks per day (OR=4.96, CI 95 % = 2.04 to12.04), cigarette smoking for more than 40 years (OR=4.32, CI 95 % = 1.69 to 11.06), smoking more than 30 cigarettes per day (OR=4.24, CI 95 % = 1.75 to 10.27), coffee consumption more than 5 cups per day (OR=4.52, CI 95 % = 1.01 to 20.12) and carbonated beverage consumption (OR=0.38, CI 95 %= 0.16 to 0.92). The great majority of laryngeal cancers could be prevented by eliminating tobacco smoking and alcohol consumption.

show abstract

The Spectrum of Laryngeal Neoplasia: The Pathologist's View

Cited by 21 publications

References 31 publications

Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility

Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility

Oral premalignant lesions: from the pathological viewpoint

Risk Factors for Laryngeal Cancer in Montenegro

Contact Info

Product

Resources

About