The spectrum of histopathological lesions in Gallbladder in cholecystectomy specimens

Gupta, Kamna; Faiz, Amir; Thakral, Rajender Kumar; Mohan, Alok; Sharma, Veena

doi:10.33545/pathol.2019.v2.i1c.22

Cited by 4 publications

(6 citation statements)

References 17 publications

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Section: Discussionsupporting

confidence: 77%

“…The mean age group of the cholecystectomy cases was 39.4 years which is comparable to Gupta K et al [20] (41.69 years). 4 th decade was the commonest age group in the present study; which is similar in the studies by Gupta K et al [20] and Islam Mj et al [21]. The age ranged from 25 years to 65 years in malignant gallbladder cases; which is comparable to Shah B et al [22], Bhattacharjee K P et al [23].…”

Section: Discussionsupporting

confidence: 77%

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Clinicopathological Evaluation of Gall-Bladder Lesions in Cholecystectomy Specimens with Special Emphasis to Incidentally Detected Cases of Gall-Bladder Carcinoma Along with Immunohistochemical Study of Cytokeratin 7 and Cytokeratin 20

Bora,

Saikia

2023

Asian Pac J Cancer Care

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Introduction: Cholecystectomy specimens show wide clinicopathological spectrum varying from common non neoplastic diseases to rare neoplastic lesions and histopathological examination the gold standard for final diagnosis. Gall Bladder Cancers (GBCs) are rare and account for 0.5% to 1.09% of all gall bladder lesions. It is either clinically suspected or incidentally diagnosed following cholecystectomy. Methods: It was a Hospital based cross-sectional Study. All cases diagnosed clinically & radiologically and operated as cholecystitis were included in the study. Histopathological diagnosis of gallbladder lesions, age & sex distribution in different gallbladder pathology, association with gall stones, Pathological pT staging of malignant cases and CK7 & CK20 immunohistochemical findings in malignant cases were observed in this study. Results: A total 340 cases of gallbladder specimens were examined histopathologically and 12 cases of gallbladder carcinoma were diagnosed. The most common histopathological diagnosis was chronic cholecystitis (79.4%) followed by chronic cholecystitis with cholesterolosis (7.6%) and adenocarcinoma (3.5%). The most common age group for gallbladder lesions was 4th decade (26.2%). Age varies from 09 – 85 years with a mean age of 39.4 years. Overall females (83%) are more commonly affected than males (17%) with male: female ratio is 1:4.96. Gallstones were present in 89.1% among total cases, 83.3% in malignant cases. Incidentally detected gallbladder carcinoma was 1.17% and most common histopathological type was adenocarcinoma NOS with Pathological pT staging was pT1 & pT2 only i.e. early stage. CK7 positivity was found in 91.6% cases and CK20 was positive in 16.7% cases. Both CK7 & CK20 was positive in 16.7% and both CK7 & CK20 was negative in one case (8.33%). Conclusions: Although the most common gall bladder histopathology diagnosis is chronic cholecystitis, the possibility of any incidental malignancy needs to be ruled out by mandatory routine histopathological examination of all cholecystectomy specimens.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 77%

Clinicopathological Evaluation of Gall-Bladder Lesions in Cholecystectomy Specimens with Special Emphasis to Incidentally Detected Cases of Gall-Bladder Carcinoma Along with Immunohistochemical Study of Cytokeratin 7 and Cytokeratin 20

Bora,

Saikia

2023

Asian Pac J Cancer Care

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“…The spectrum of ailments that afflict the gallbladder (GB) can be inflammatory, congenital, or neoplastic in nature [1,2]. The signs and symptoms elicited by these pathologies evoke the need for surgical intervention through the means of either open or laparoscopic cholecystectomy.…”

Section: Introductionmentioning

confidence: 99%

The Spectrum of Gallbladder Histopathology at a Tertiary Hospital in a Developing Country: A Retrospective Study

Almas¹,

Murad²,

Khan³

et al. 2020

Cureus

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“…The burden of incidental carcinoma is reportedly higher in North Indian states (Delhi, Bihar, UP)[ 1 15 16 ] than in the southern states (Tamil Nadu). [ 17 18 ] This ranged from 3% to 1% for the northern states and 0.5% for the southern states[ 1 15 16 17 18 19 20 21 ] [ Figure 1 ].…”

Section: Resultsmentioning

confidence: 99%

Outcome of routine histopathological examination of gallbladder specimen following elective laparoscopic cholecystectomy

et al. 2021

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BACKGROUND: Gallstone disease is one of the commonest surgical ailments encountered in our setup. Its prevalence in India varies from 2% to 29%. Although cholelithiasis accounts for more than 95% of gall bladder related disease, routine histopathological examination (HPE) is vital. It reveals a myriad of benign as well as the malignant surgical pathology of the gallbladder (GB). This part of the world is considered as an endemic region for GB carcinoma as well as gallstone disease. This study intends to evaluate the outcome of the routine HPE of laparoscopic cholecystectomy specimens. METHODS: This retrospective observational study evaluated the results of the routine HPE of elective laparoscopic cholecystectomy specimens of single tertiary care center. Patients suspected or diagnosed with carcinoma gall bladder were excluded. Demographic data such as age, sex, and pathology results were recorded. RESULTS: From January 2017 to December 2019, HPEs of 921 patients who had undergone laparoscopic cholecystectomy specimens were analyzed. 97.6% specimens had benign lesion of which chronic calculus cholecystitis was predominantly high (95.01%) followed by cholesterosis (9.9%) and xanthogranulomatous cholecystitis (6.51%). Incidental carcinoma gall bladder was observed in 17 specimens accounting for 1.85%. Mean age of patients who underwent cholecystectomy was 43.10 ± 13.90 with female to male ratio of 3.23:1. CONCLUSION: Chronic calculus cholecystitis was the most common gall bladder disease with high female preponderance to all GB pathologies. This study affirms the importance of routine HPE after cholecystectomy as early incidental detection of carcinoma gall bladder alters the postoperative management approach and patients are expected to have a better outcome with it.

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The spectrum of histopathological lesions in Gallbladder in cholecystectomy specimens

Cited by 4 publications

References 17 publications

Clinicopathological Evaluation of Gall-Bladder Lesions in Cholecystectomy Specimens with Special Emphasis to Incidentally Detected Cases of Gall-Bladder Carcinoma Along with Immunohistochemical Study of Cytokeratin 7 and Cytokeratin 20

Clinicopathological Evaluation of Gall-Bladder Lesions in Cholecystectomy Specimens with Special Emphasis to Incidentally Detected Cases of Gall-Bladder Carcinoma Along with Immunohistochemical Study of Cytokeratin 7 and Cytokeratin 20

The Spectrum of Gallbladder Histopathology at a Tertiary Hospital in a Developing Country: A Retrospective Study

Outcome of routine histopathological examination of gallbladder specimen following elective laparoscopic cholecystectomy

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