Outcome of routine histopathological examination of gallbladder specimen following elective laparoscopic cholecystectomy

Abstract

BACKGROUND: Gallstone disease is one of the commonest surgical ailments encountered in our setup. Its prevalence in India varies from 2% to 29%. Although cholelithiasis accounts for more than 95% of gall bladder related disease, routine histopathological examination (HPE) is vital. It reveals a myriad of benign as well as the malignant surgical pathology of the gallbladder (GB). This part of the world is considered as an endemic region for GB carcinoma as well as gallstone disease. This study intends to evaluate the outcome of the routine HPE of laparoscopic cholecystectomy specimens. METHODS: This retrospective observational study evaluated the results of the routine HPE of elective laparoscopic cholecystectomy specimens of single tertiary care center. Patients suspected or diagnosed with carcinoma gall bladder were excluded. Demographic data such as age, sex, and pathology results were recorded. RESULTS: From January 2017 to December 2019, HPEs of 921 patients who had undergone laparoscopic cholecystectomy specimens were analyzed. 97.6% specimens had benign lesion of which chronic calculus cholecystitis was predominantly high (95.01%) followed by cholesterosis (9.9%) and xanthogranulomatous cholecystitis (6.51%). Incidental carcinoma gall bladder was observed in 17 specimens accounting for 1.85%. Mean age of patients who underwent cholecystectomy was 43.10 ± 13.90 with female to male ratio of 3.23:1. CONCLUSION: Chronic calculus cholecystitis was the most common gall bladder disease with high female preponderance to all GB pathologies. This study affirms the importance of routine HPE after cholecystectomy as early incidental detection of carcinoma gall bladder alters the postoperative management approach and patients are expected to have a better outcome with it.

Gall bladder diseases: a study of histopathological spectrum of cholecystectomy specimens from rural tertiary hospital in Telangana state during COVID pandemic

“…Routine histopathological examination (HPE) is vital as we may miss rare occasions of malignancy/ premalignant lesions. 1 The clinical symptoms in most cases remain pain, fever and other non-specific symptoms but gallbladder diseases present with varied histopathological spectrum ranging from acute or chronic inflammation to metaplasia and even malignancies. It is well known that a range of racial, cultural and lifestyle factors impact the pathological spectrum of gall bladder diseases across the globe.…”

Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS

“…Several different computational approaches, such as Runge-Kutta methods, finite element, numerical linear algebra, statistics, numerical analysis, tensor analysis, and the most important one, Neural Networks (NNs), have been used in various fields of researches such as chemical engineering [1][2][3][4][5][6][7][8][9], electrical engineering [10][11][12][13][14][15][16][17][18][19], health and biology [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34], fluid mechanic engineering [35][36][37][38][39][40][41][42][43][44][45][46], civil engineering [47][48][49]...…”