The spectrum of gastric disease associated with Helicobacter pylori and other infectious gastritides

Guarner, Jeannette

doi:10.1007/s11894-004-0065-7

Cited by 12 publications

(12 citation statements)

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“…In adults, gastric glandular atrophy and/or intestinal metaplasia are frequently associated with H. pylori infection and both are considered preneoplastic lesions [12,13]. This relationship is still controversial in the pediatric population and the incidence of gastric atrophy and/or intestinal metaplasia is not consistent among published studies [2,13,[24][25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

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In French Children, Primary Gastritis Is More Frequent Than Helicobacter pylori Gastritis

et al. 2008

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The aim of this study was to analyze the histological characteristics according to the updated Sydney classification (intensity of gastritis, degree of activity, gastric atrophy, intestinal metaplasia, and Helicobacter pylori) in symptomatic children referred for upper gastrointestinal endoscopy. A 4-year retrospective descriptive study was carried out in 619 children (282 females and 337 males), median age 3.75 years (15 days to 17.3 years) referred for endoscopy. Six gastric biopsies were done (three antrum and three corpus) for histological analysis (n = 4), direct examination and H. pylori culture (n = 2). H. pylori status was considered positive if at least two out of three tests were positive and negative if all three tests were negative. The results showed that only 66 children (10.66%) were H. pylori positive. Histological antral and corpus gastritis was detected in, respectively, 53.95% and 59.12% of all cases, most of them of mild grade 1. Antral and corpus activity was grade 1 in 18.57% and 20.03% of cases. H. pylori-positive versus H. pylori-negative children did differ in terms of moderate and marked histological gastritis and grade 2 or 3 activities. One girl had moderate gastric atrophy and another one moderate intestinal metaplasia, both being H. pylori negative. The findings indicate that primary antrum and corpus gastritis is 5.3 and 6.9 times, respectively, more frequent than H. pylori gastritis in French children, with usually mild histological gastritis and activity. Gastric atrophy and intestinal metaplasia are rare.

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Section: Discussionmentioning

confidence: 99%

“…Mucosal atrophy and intestinal metaplasia of the stomach are frequently found in gastric biopsy specimens of adults infected with H. pylori [12]. However, if H. pylori infection is frequently acquired during childhood, its role in gastric atrophy and intestinal metaplasia has not been extensively searched for and described [13].…”

Section: Introductionmentioning

confidence: 99%

In French Children, Primary Gastritis Is More Frequent Than Helicobacter pylori Gastritis

et al. 2008

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“…Helicobacter pylori ( H. pylori ) is a gram-negative, spiral-shaped bacterium that mainly inhabits and multiplies in the gastric mucosa [1,2]. The bacterium produces the enzyme urease and this convert urea into carbon dioxide and ammonia.…”

Section: Introductionmentioning

confidence: 99%

“…The bacterium produces the enzyme urease and this convert urea into carbon dioxide and ammonia. The ammonium envelope enables it to resist the acidic environment in the stomach [1]. The prevalence of H. pylori varies widely from region to region, with an especially marked difference between industrial and developing countries.…”

Section: Introductionmentioning

confidence: 99%

The occupational risk of Helicobacter pyloriinfection among gastroenterologists and their assistants

et al. 2011

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BackgroundHelicobacter pylori is a widely spread bacterium that mainly inhabits the gastric mucosa and can lead to serious illnesses such as peptic ulcer disease, gastric carcinoma and gastric MALT lymphoma. The oral-oral route seems to be the main transmission route. The fact that endoscopes are contaminated after being used to perform a gastroscopy leads one to question whether gastroenterologists and endoscopy nurses and assistants run a higher risk of infection.MethodsA systematic search for literature was conducted in the MEDLINE and EMBASE databases and further publications were found in reference lists of relevant articles. Epidemiological studies on the occupational exposure of endoscopy personnel were collected and their quality was assessed. Pooled effect estimates were identified in a meta-analysis.ResultsOf the 24 studies included in the analysis, 15 were considered to be methodologically good. Of these 15 studies, eight single studies showed a statistically significant increased risk of infection for gastroenterologists, and five for their assistants. Meta-analysis across all methodologically good studies found a statistically significant risk of 1.6 (95%CI 1.3-2.0) for doctors. The pooled effect estimates also indicated a statistically significant risk of Helicobacter pylori infection (RR 1.4; 95%CI 1.1-1.8) for assistants too.When studies are stratified by medical and non-medical control groups, statistically significant risks can only be recognised in the comparison with non-medical controls.ConclusionsIn summary, our results demonstrated an increased risk of Helicobacter pylori infection among gastroenterological personnel. However, the choice of control group is important for making a valid assessment of occupational exposure risks.

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“…Bacteria produces the urease enzyme which changes urea into carbon dioxide and ammonia. Ammonium covers the acidic environment in the stomach [11]. The infection usually occurs in the early childhood and remains permanently in the host if not treated [1].…”

Section: Discussionmentioning

confidence: 99%

Is Helicobacter Pylori a Possible Etiopathogenic Factor in Chronic Tonsillitis?

Ozgun¹

2015

Ann Clin Anal Med

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Anahtar KelimelerHelikobakter Pilori; Tonsillektomi; Tonsil; Tonsillit; Giemsa Abstract Aim: Helicobacter pylori is the major gastric pathogen which has an important role in the etiopathogenesis of chronic gastritis. We investigated the presence of Helicobacter pylori as an extragastric reservoir in the tonsillectomy specimens to display if it is an etiologic factor in the development of chronic tonsilitis. Material and Method: In the current study, 100 cases with chronic tonsilitis were examined in bilateral tonsillectomy specimens. The colonization of the microorganism have been evaluated with hematoxylineosin and giemsa stains under the light microscope.Results: Helicobacter pylori has been detected in 33 cases (33%) on one side of the bilateral tonsillectomy specimens while it has been seen in 15 cases (15%) on both sides which demonstrated positivity in 48 cases (48%) in total. No colonization has been observed in the remaining 52 cases (52%). Discussion: Due to the considerable positivity in our study, the histopathologic evaluation of tonsillary Helicobacter pylori colonization may be instrumental in the etiologic association with chronic tonsillitis.

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The spectrum of gastric disease associated with Helicobacter pylori and other infectious gastritides

Cited by 12 publications

References 51 publications

In French Children, Primary Gastritis Is More Frequent Than Helicobacter pylori Gastritis

In French Children, Primary Gastritis Is More Frequent Than Helicobacter pylori Gastritis

The occupational risk of Helicobacter pyloriinfection among gastroenterologists and their assistants

Is Helicobacter Pylori a Possible Etiopathogenic Factor in Chronic Tonsillitis?

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