The spectrum of antecedent infections in Guillain-Barré syndrome

Jacobs, Bart C.; Rothbarth, P. H.; Meché, F.G.A. van der; Herbrink, Paul; Schmitz, P. I. M.; Klerk, M. A. de; Doorn, Pieter A. van

doi:10.1212/wnl.51.4.1110

Cited by 746 publications

(647 citation statements)

References 15 publications

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“…In our study, ages were uniformly distributed within an age range of 2-12 years which is not in accordance with studies by Rees et al, Italian Guillain-Barré Syndrome Study Group and Van Koningsveld et al where the incidence of GBS was found to increase with the age 2,6,7 . In studies by Jacobs et al and Farhoudi et al, the percentage of patients with preceding illness was 70% in comparison to 39% in our study 5,8 . In the study by Farhoudi et al, quadriparesis was seen in 91% and paraparesis in 07% whereas in our study 67% had quadriparesis and 33% had paraparesis 5 .…”

Section: Studies By Rees Et Al Yuan Et Al and Rocha Et Alcontrasting

confidence: 72%

Guillain Barre Syndrome: A clinical observational study in Indian paediatric patients

Swaroop¹,

Javadekar²

2017

Sri Lanka J Child Health

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Background: Guillain Barre Syndrome (GBS) is the most common cause of acute flaccid paralysis (AFP) after nationwide poliomyelitis eradication measures in India. AFP surveillance has increased the detection of cases. New modalities of management such as artificial ventilation and intravenous immunoglobulin (IVIG) are expected to increase survival of GBS patients.Objective: To study the clinical presentation, prognostic factors and outcome in GBS patients admitted to a tertiary care centre in Gujarat, India.

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Section: Studies By Rees Et Al Yuan Et Al and Rocha Et Alcontrasting

confidence: 72%

Guillain Barre Syndrome: A clinical observational study in Indian paediatric patients

Swaroop¹,

Javadekar²

2017

Sri Lanka J Child Health

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“…The disease diversity is associated with the variety in preceding infections. Campylobacter jejuni is the predominant infection triggering GBS worldwide,14 and is associated with severe acute motor axonal neuropathy (AMAN)‐type of GBS with a poor clinical outcome 15. Cytomegalovirus in contrast can cause severe senso‐motoric disorders and a GBS subtype described as acute inflammatory demyelinating polyneuropathy (AIDP) 16.…”

Section: Introductionmentioning

confidence: 99%

Zika virus and Guillain–Barré syndrome in Bangladesh

GeurtsvanKessel

Islam

et al. 2018

Ann Clin Transl Neurol

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ObjectivePrevious studies have associated Guillain–Barré syndrome (GBS) with Zika virus (ZIKV) outbreaks in South America and Oceania. In Asia, ZIKV is known to circulate widely, but the association with Guillain–Barré syndrome is unclear. We investigated whether endemic ZIKV infection is associated with the development of GBS.MethodsA prospective study was conducted from 2011 to 2015 in Bangladesh. A total of 418 patients and 418 healthy family controls were included in the study. Patients were diagnosed with GBS prior to inclusion according to established criteria. Detailed information on the epidemiology, clinical presentation, electrophysiology, diagnosis, disease severity, and clinical course were obtained during a follow‐up of 1 year using a predefined protocol.Results ZIKV‐neutralizing antibodies were detected in our study from 2013 onwards. The prevalence of ZIKV‐neutralizing antibodies was not significantly higher in patients with GBS compared to healthy controls (OR 2.23, P = 0.14, 95% CI 0.77–6.53). Serological evidence for prior ZIKV infection in patients with GBS was associated with more frequent cranial, sensory, and autonomic nerve involvement compared to GBS patients with Campylobacter jejuni, the predominant preceding infection in GBS worldwide. Nerve‐conduction studies revealed that ZIKV antibodies were associated with a demyelinating subtype of GBS, while C. jejuni infections were related to an axonal subtype.InterpretationNo significant association was found between ZIKV infection and GBS in Bangladesh, but GBS following ZIKV infection was characterized by a distinct clinical and electrophysiological subtype compared to C. jejuni infection. These findings indicate that ZIKV may precede a specific GBS subtype but the risk is low.

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“…In addition, our results are not in accordance with those published by Jacobs, van Doorn, Groeneveld, Tio‐Gillen, & van der Meche (1997), Jacobs et al. (1998). They reported that anti‐GM2 IgM antibodies were found more often in patients with GBS with CMV infection (22%) than in patients without the infection.…”

Section: Discussionmentioning

confidence: 99%

Association of anti‐gangliosides antibodies and anti‐CMV antibodies in Guillain–Barré syndrome

et al. 2017

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IntroductionNumerous types of infection were closely related to GBS, mainly including Campylobacter jejuni, Cytomegalovirus, which may lead to the production of anti‐gangliosides antibodies (AGA). Currently, although there are increased studies on the AGA and a few studies of anti‐CMV antibodies in GBS, the association between them remains poorly documented. Therefore, our research aims to analyze the correlation of anti‐CMV antibodies and AGA in GBS.MethodsA total of 29 patients with GBS were enrolled in this study. The CMV antibodies were tested by the electrochemiluminescence immunoassay “ECLIA” (Roche Diagnostics GmbH). The serum gangliosides were determined by The EUROLINE test kit.ResultsOf the 29 patients with GBS, 9 (31%) were AGA‐seropositive, in which 22 were CMV‐IgG positive in CSF at the same time, but all 29 samples were CMV‐IgM negative in both serum and CSF. In the AGA‐positive group, the rate of both serum and CSF positive was 87.5% (7/8), higher than 50% (7/14) of the negative group, although no statistical significance was found. In addition, we found that there was a trend of higher ratio of men, a younger age onset, less frequent preceding infection, a higher level of CSF proteins, and less frequent cranial nerve deficits, although the data did not reach a statistical significance.ConclusionIn spite of no statistical significance association was found between serum AGA and CMV‐IgG in serum and CSF. However, we found that there was a trend of high positive rate of both serum and CSF‐CMV‐IgG in AGA‐positive than the negative group. So we should further expand the sample size to analyze the association between AGA and CMV or other neurotropic virus antibodies in various diseases, to observe whether they could be serological marker of these diseases (especially GBS) or the underlying pathogenesis.

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The spectrum of antecedent infections in Guillain-Barré syndrome

Abstract: Recent infections with C. jejuni, cytomegalovirus, Epstein-Barr virus, and M. pneumoniae are specifically related to GBS. The variety of infections may contribute to the clinical and immunologic heterogeneity of GBS.

Cited by 746 publications

References 15 publications

Guillain Barre Syndrome: A clinical observational study in Indian paediatric patients

Guillain Barre Syndrome: A clinical observational study in Indian paediatric patients

Zika virus and Guillain–Barré syndrome in Bangladesh

Association of anti‐gangliosides antibodies and anti‐CMV antibodies in Guillain–Barré syndrome

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