The specificity of proanthocyanidin-protein interactions.

Hagerman, Ann; Butler, Larry G.

doi:10.1016/s0021-9258(19)69462-7

Cited by 844 publications

(271 citation statements)

References 19 publications

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“…2D-G). The formation of hydrogen bonds between the carbonyl groups of collagen molecules and OH groups of GSE (Hagerman and Butler 1981) on the surface of the drug-loaded nanoparticles might facilitate the initial retention and attachment of the nanoparticles to the dentin collagen matrix.…”

Section: Discussionmentioning

confidence: 99%

Proanthocyanidins-Loaded Nanoparticles Enhance Dentin Degradation Resistance

et al. 2017

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Previous studies reported that grapeseed extract (GSE), which is rich in proanthocyanidins (PAs), improves the biodegradation resistance of demineralized dentin. This study aimed to investigate the effect of a new GSE delivery strategy to demineralized dentin through loading into biodegradable polymer poly-[lactic-co-glycolic acid] (PLGA) nanoparticles on the biodegradation resistance in terms of structural stability and surface/bulk mechanical and biochemical properties with storage time in collagenase-containing solutions. GSE-loaded nanoparticles were synthetized by nanoprecipitation at PLGA/GSE (w/w) ratios of 100:75, 100:50, and 100:25 and characterized for their morphological/structural features, physicochemical characteristics, and drug loading, entrapment, and release. Nanoparticle suspensions in distilled water (12.5% w/v) were applied (1 min) to demineralized dentin specimens by simulating pulpal pressure. The nanoparticle delivery was investigated by scanning electron microscopy (SEM)/transmission electron microscopy (TEM), and the GSE release from the delivered nanoparticles was further characterized. The variations in surface and bulk mechanical properties were characterized in terms of reduced elastic-modulus, hardness, nanoindentation testing, and apparent elastic-modulus with a storage time up to 3 mo. Hydroxyproline release with exposure to collagenase up to 7 d was estimated. An etch-and-rinse dentin adhesive was applied to investigate the morphology of the resin-dentin interface after nanoparticle delivery. Treatment with the GSE-loaded nanoparticles enhanced the collagen fibril structural resistance, reflected from the TEM investigation, and improved the biomechanical and biochemical stability of demineralized dentin. Nanoparticles having PLGA/GSE of 100:75 (w/w) showed the highest cumulative GSE release and were associated with the best improvement in biodegradation resistance. TEM/SEM showed the ability of the nanoparticles to infiltrate dentinal tubules' main and lateral branches. SEM revealed the formation of a uniform hybrid layer and well-formed resin tags with the presence of numerous nanoparticles located within the dentinal tubules and/or attached to the resin tag. This study demonstrated the potential significance of delivering collagen crosslinkers loaded into biodegradable polymer nanoparticles through the dentinal tubules of demineralized dentin on the biodegradation resistance.

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Section: Discussionmentioning

confidence: 99%

Proanthocyanidins-Loaded Nanoparticles Enhance Dentin Degradation Resistance

et al. 2017

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“…Acidic proline-rich proteins, along with statherins and histatins, have a high affinity for hydroxyapatite and are prominent components of the tooth enamel protein pellicle (Lamkin et al, 1996). Proline-rich proteins, particularly basic proline-rich proteins, have a particularly high affinity for dietary polyphenols (Hagerman and Butler, 1981), as do histatins (Bennick and Yan, 1995).In the present study, we examined whether the salivary protein pellicle on teeth promotes tooth-staining and/or whether salivary proteins in solution might promote or reduce tooth staining. We used parotid saliva, since it contains histatins and proline-rich proteins and, since it is ductal saliva, interpretation of results is not complicated by the presence of exogenous components found in whole-mouth saliva.…”

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confidence: 99%

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confidence: 99%

Salivary Proteins Interact with Dietary Constituents to Modulate Tooth Staining

et al. 2005

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Dietary components rich in polyphenols-for example, tea and red wine-are thought to cause tooth staining. In the present study, hydroxyapatite was used as a model of enamel for study of the influence of salivary proteins on the binding of different polyphenols to hydroxyapatite in vitro. Neither salivary protein pellicles nor salivary proteins in solution significantly altered the binding of the small polyphenol epigallocatechin to hydroxyapatite. However, hydroxyapatite binding of anthocyanin, a small grape-skin-derived polyphenol, or the larger polyphenols of black tea was increased by the presence of salivary proteins, either as a pellicle or in solution. Proline-rich proteins were enriched from parotid saliva and found to increase binding of anthocyanin and black tea polyphenols to hydroxyapatite, while enriched histatins did not increase binding. It is concluded that some salivary proteins, including proline-rich protein, can mediate increased staining of enamel by red-wine- and black-tea-derived polyphenols.

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“…The levels of tannic acid added to the diets were established based on the analysis of the amount of condensed tannin present in the sorghum, which, according to the methodology of HCL-Butanol (Hagerman & Butler, 1981) carried out at the Bromatology Laboratory of UAG-UFRPE A9904 (cultivar A9904) was 2.55% of total condensed tannin in DM. Control sorghum (cultivar BRS Ponta Negra) 0.92% of total condensed tannin in DM by Terrill et al (1992) carried out at EMBRAPA Sete Lagoas -MG.…”

Section: Dietsmentioning

confidence: 99%

Effect of increasing tannic acid addition to the diet on milk quality in the semiarid region

et al. 2022

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The study aimed to evaluate the effect of adding tannic acid to the diet on the milk quality of cows. The five primiparous crossbred cows (Holstein x Zebu) were used, with about four years old, the average body weight of 420 ± 30 kg, 100 days of lactation initial average production of 18 ± 4 kg of milk/cow/day. The treatments consisted of increasing tannic acid (0; 1.3; 2.6; 3.9 and 5.2%) to replace corn bran in the diet, based on dry matter. The sensory attributes of odor had a significant effect (P < 0.05) of the inclusion of tannic acid in the diet. The odor attributes showed a lower average for the control treatment, and these attributes also showed orthogonal contrast, except the characteristic cow, that is, the control group differed from the treatments as the tannin was introduced, the attribute value became higher compared to the control group. The inclusion of 5.2% tannic acid in dairy cows' diet promoted a slight variation in the taste of milk. However, it did not alter the quality or acceptance of this milk by consumers.

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The specificity of proanthocyanidin-protein interactions.

Cited by 844 publications

References 19 publications

Proanthocyanidins-Loaded Nanoparticles Enhance Dentin Degradation Resistance

Proanthocyanidins-Loaded Nanoparticles Enhance Dentin Degradation Resistance

Salivary Proteins Interact with Dietary Constituents to Modulate Tooth Staining

Effect of increasing tannic acid addition to the diet on milk quality in the semiarid region

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