The spatiotemporal program of zonal liver regeneration following acute injury

Ben‐Moshe, Shani; Veg, Tamar; Manco, Rita; Dan, Stav; Papinutti, Delfina; Lifshitz, Aviezer; Kolodziejczyk, Aleksandra A.; Halpern, Keren Bahar; Elinav, Eran; Itzkovitz, Shalev

doi:10.1016/j.stem.2022.04.008

Cited by 76 publications

(101 citation statements)

References 97 publications

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“…Moreover, as mentioned, reduced expression of hepatospecific genes is accompanied by the reactivation of fetal isoforms, further contributing to the abandonment of fundamental metabolic functions by the injured liver [88,90,94,95]. The loss of liver-enriched and zonated gene expression, and the upregulation of fetal-specific genes, have been recently confirmed by single-cell RNAseq analyses of hepatocytes isolated from experimental models of liver injury and regeneration, as well as in clinical samples from patients with liver cirrhosis or alcoholic hepatitis [91,[96][97][98][99]. Importantly, the reactivation of fetal hepatic genes and fetal isoforms can be relevant not only towards the loss of liver functions, as it may also herald the development of cancer.…”

Section: Loss Of Hepatic Function In Liver Diseasementioning

confidence: 78%

Loss of liver function in chronic liver disease: An identity crisis

Berasain¹,

Arechederra²,

Argemí³

et al. 2023

Journal of Hepatology

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Section: Loss Of Hepatic Function In Liver Diseasementioning

confidence: 78%

Loss of liver function in chronic liver disease: An identity crisis

Berasain¹,

Arechederra²,

Argemí³

et al. 2023

Journal of Hepatology

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“…Considering that atherosclerosis is a focal disease that preferentially develops in regions where disturbed blood flow occurs, and the flow pattern is turbulent/oscillatory flow ( 10 , 19 ), the spatio-temporal and biomechanical basis of atherosclerosis remain to be validated ( 69 ). The focal nature of atherogenesis resembles the zonation phenomenon in the liver, which is coordinated by multiple cell types ( 70 , 71 ). We term this phenomenon “aorta zonation”.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Vascular homeostasis in atherosclerosis: A holistic overview

Lyu²,

Ilyas

et al. 2022

Front. Immunol.

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Atherosclerosis refers to the deposition of lipids and the co-existence of inflammation and impaired inflammation resolution in pan-vasculature, which causes lumen narrowing, hardening, plaque formation, and the manifestation of acute cardiovascular events. Emerging evidence has suggested that vascular circulation can be viewed as a complex homeostatic system analogous to a mini-ecosystem which consists of the vascular microenvironment (niche) and the crosstalk among phenotypically and functionally diverse vascular cell types. Here, we elucidate how cell components in the vascular wall affect vascular homeostasis, structure, function, and atherosclerosis in a holistic perspective. Finally, we discuss the potential role of vascular-stabilizing strategies including pharmacotherapies, natural substances and lifestyle modifications, in preventing cardiovascular diseases by preserving vascular integrity and homeostasis.

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“…Extensive mouse and human research have shown that neutrophils and macrophages exert a pivotal part in the foundation, development, and reversion of liver diseases, including in guiding tissue remodeling. With the progress of technology, more and more myeloid cell subtypes have been identified and located by single-cell multimodal omics ( 8 – 12 ). Each myeloid type acts as a unique individual participating in the immune response.…”

Section: Introductionmentioning

confidence: 99%

Myeloid cells in alcoholic liver diseases: Mechanism and prospect

Chen

et al. 2022

Front. Immunol.

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Alcoholic liver disease (ALD) is a leading chronic liver disease in which immune cells play a vital role. Myeloid cells have been extensively studied in ALD, including granulocytes, macrophages, monocytes, and dendritic cells, which are involved in the occurrence and progression of steatosis, inflammation, fibrosis, and eventual cirrhosis. These cells can be popularly targeted and regulated by factors from different sources, including cytokines secreted by other cells, extracellular vesicles, and substances in serum—for example, infiltration of monocytes or neutrophils, activation of Kupffer cells, and polarization of macrophages. These processes can affect and change the function and phenotype of myeloid cells. Here we mainly review the key mediators that affect the infiltration and function of mainly myeloid cells in ALD as well as their regulatory mechanisms on target cells, which may provide novel immunotherapeutic approaches. The single-cell multimodal omics of myeloid cells is also discussed to help transform them into basic research or therapeutic strategy of ALD clinically.

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The spatiotemporal program of zonal liver regeneration following acute injury

Cited by 76 publications

References 97 publications

Loss of liver function in chronic liver disease: An identity crisis

Loss of liver function in chronic liver disease: An identity crisis

Vascular homeostasis in atherosclerosis: A holistic overview

Myeloid cells in alcoholic liver diseases: Mechanism and prospect

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