Vascular homeostasis in atherosclerosis: A holistic overview

Xu, Suowen; Lyu, Qing; Ilyas, Iqra; Tian, Xiaoyu; Weng, Jianping

doi:10.3389/fimmu.2022.976722

Cited by 8 publications

(4 citation statements)

References 73 publications

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“…Figure 6 provides a protein network-centered view of Table 4 and shows that proteins regulating vitamin D's non-genomic pharmacology can physically interact and affect atherosclerosis by regulating the balance between autophagy ( 121 ), apoptosis ( 122 ), endoplasmic reticulum stress response ( 94 ), cellular senescence ( 123 , 124 ), and tissue homeostasis ( 125 ).…”

Section: Resultsmentioning

confidence: 99%

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Fliri,

Kajiji

2024

Front. Cardiovasc. Med.

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Among the leading causes of natural death are cardiovascular diseases, cancer, and respiratory diseases. Factors causing illness include genetic predisposition, aging, stress, chronic inflammation, environmental factors, declining autophagy, and endocrine abnormalities including insufficient vitamin D levels. Inconclusive clinical outcomes of vitamin D supplements in cardiovascular diseases demonstrate the need to identify cause-effect relationships without bias. We employed a spectral clustering methodology capable of analyzing large diverse datasets for examining the role of vitamin D's genomic and non-genomic signaling in disease in this study. The results of this investigation showed the following: (1) vitamin D regulates multiple reciprocal feedback loops including p53, macrophage autophagy, nitric oxide, and redox-signaling; (2) these regulatory schemes are involved in over 2,000 diseases. Furthermore, the balance between genomic and non-genomic signaling by vitamin D affects autophagy regulation of macrophage polarization in tissue homeostasis. These findings provide a deeper understanding of how interactions between genomic and non-genomic signaling affect vitamin D pharmacology and offer opportunities for increasing the efficacy of vitamin D-centered treatment of cardiovascular disease and healthy lifespans.

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Section: Resultsmentioning

confidence: 99%

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Fliri,

Kajiji

2024

Front. Cardiovasc. Med.

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“…Several typical phenomena of endotheliosis can be identified, and it is important to note that normal interactions between ECs, blood plasma cells and proteins, other arterial cells, and the subendothelial extracellular matrix are inevitably disrupted in this condition. Therefore, the dysfunction of ECs cannot be isolated a priori when analyzing these phenomena [281].…”

Section: Endotheliosis As a Key Phenomenon Of Age-related Changes And...mentioning

confidence: 99%

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

Gusev

Sarapultsev

2023

IJMS

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Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from a general pathology perspective, particularly with regard to atherogenesis patterns in the context of both canonical and non-classical inflammation types. In this review, we analyze various typical phenomena and outcomes of cellular pro-inflammatory stress in atherosclerosis, as well as the role of endothelial dysfunction in local and systemic manifestations of low-grade inflammation. We also present the features of immune mechanisms in the development of productive inflammation in stable and unstable plaques, along with their similarities and differences compared to canonical inflammation. There are numerous factors that act as inducers of the inflammatory process in atherosclerosis, including vascular endothelium aging, metabolic dysfunctions, autoimmune, and in some cases, infectious damage factors. Life-critical complications of atherosclerosis, such as cardiogenic shock and severe strokes, are associated with the development of acute systemic hyperinflammation. Additionally, critical atherosclerotic ischemia of the lower extremities induces paracoagulation and the development of chronic systemic inflammation. Conversely, sepsis, other critical conditions, and severe systemic chronic diseases contribute to atherogenesis. In summary, atherosclerosis can be characterized as an independent form of inflammation, sharing similarities but also having fundamental differences from low-grade inflammation and various variants of canonical inflammation (classic vasculitis).

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“…The naringenin-7-O-glucoside in the traditional Chinese medicine dracocephalum rupestre protects against cardiovascular disease [81]. Figure 4: Quercetin, a compound found in tea, wine, apples, and onions and used to treat cardiovascular disease [82]. The risk of cardiovascular disease decreases with increased quercetin consumption.…”

Section: Wwwjrasbcommentioning

confidence: 99%

Plant & its Bioactive Components Uses in Cardio-Potential Diseases: A Sectional Study for Different Herbs

Kumar,

Sood,

Nirala

et al. 2023

J. Res. Appl. Sci. Biotechnol.

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Thirty percent of all deaths that occur each year can be attributed to heart disease, stroke, and other forms of cardiovascular disease. The World Health Organisation (WHO) predicts that by the year 2030, the annual death toll from cardiovascular diseases will have increased to 22.2 million, up from the present annual total of 17.9 million. Mortality rates tend to go up in populations as they get older. The chance of dying from cardiovascular disease is significantly higher for females (51%) than it is for males (42%). The majority of people treat and prevent cardiovascular disease by using plant-based medications (also known as phytochemicals), either in addition to or in instead of pharmaceuticals that are readily available on the market. In this study, the efficacy of treating cardiovascular illness is evaluated using 92 different plants, including 15 terrestrial plants. A number of different medicinal herbs, including Daucus carota, Nerium oleander, Amaranthus Viridis, Ginkgo biloba, Terminalia arjuna, Picrorhiza kurroa, Salvia miltiorrhiza, Tinospora cordifolia, Mucuna pruriens, Hydrocotyle asiatica, Bombax ceiba, and Andrographis paniculate, are utilised to treat cardiovascular disease. There are a variety of active phytochemicals found in these plants, some of which include flavonoids, polyphenols, plant sterols, plant sulphur compounds, and terpenoids. Flavonoids, in general, are known to increase vasodilation by inhibiting the oxidation of low-density lipoprotein (LDL). Plant sterols reduce the amount of cholesterol in the blood, which in turn protects against cardiovascular disease. Plant sulphur compounds protect against cardiovascular disease in addition to their role in the activation of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) and the inhibition of cholesterol formation. The incidence of cardiovascular disease can be reduced by increasing the synthesis of ATP in mitochondria, and terpenoids can diminish atherosclerotic lesion in the aortic valve. Even though several physiologically active compounds with acknowledged biological functions have been found in a wide variety of plants, the prevalence of cardiovascular disease continues to rise, making it imperative that effective CVD prevention and treatment strategies be developed. More research is required to understand both the mechanism and the individual phytochemicals in plants that treat CVD. GRAPHICAL ABSTRACT

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Vascular homeostasis in atherosclerosis: A holistic overview

Cited by 8 publications

References 73 publications

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

Plant & its Bioactive Components Uses in Cardio-Potential Diseases: A Sectional Study for Different Herbs

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