The Sparing Effect of Low-Dose Esmolol on Sevoflurane during Laparoscopic Gynaecological Surgery

Moon, Young Eun; Hwang, Wonjung; Koh, Hyun Jung; Min, Ji Young; Lee, J

doi:10.1177/147323001103900529

Cited by 20 publications

(21 citation statements)

References 32 publications

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“…30 Moon and colleques reported that using esmolol might decrease PACU recovery duration in gynecological surgery patients. 6 In this study we observed that besides lowering anesthetic requirements adjuvant esmolol also decreases analgesic requirements and VAS scores in postoperative 24 h. Some previous studies also supported our findings. Bhawna and colleques reported that in lower abdominal surgery patients addition of esmolol to isoflurane might decrease both anestetic and postoperative analgesic requirements.…”

Section: Discussionsupporting

confidence: 88%

Effect of intraoperative esmolol infusion on anesthetic, analgesic requirements and postoperative nausea-vomitting in a group of laparoscopic cholecystectomy patients

Dereli

Tutal

Babayiğit

et al. 2015

Brazilian Journal of Anesthesiology (English Edition)

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Purpose: Postoperative pain and nausea/vomitting (PNV) are common in laparoscopic cholecystectomy patients. Sympatholytic agents might decrease requirements for intravenous or inhalation anesthetics and opioids. In this study we aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analgesic requirements, postoperative pain and PNV. Methods: Sixty patients have been included. Propofol, remifentanil and vecuronium were used for induction. Study groups were as follows; I ---Esmolol infusion was added to maintenance anesthetics (propofol and remifentanil), II ---Only propofol and remifentanil was used during maintenance, III ---Esmolol infusion was added to maintenance anesthetics (desflurane and remifentanil), IV ---Only desflurane and remifentanil was used during maintenance. They have been followed up for 24 h for PNV and analgesic requirements. Visual analog scale (VAS) scores for pain was also been evaluated. Results: VAS scores were significantly lowest in group I (p = 0.001---0.028). PNV incidence was significantly lowest in group I (p = 0.026). PNV incidence was also lower in group III compared to group IV (p = 0.032). Analgesic requirements were significantly lower in group I and was lower in group III compared to group IV (p = 0.005). Heart rates were significantly lower in esmolol groups (group I and III) compared to their controls (p = 0.001) however blood pressures were similar in all groups (p = 0.594). Comparison of esmolol groups with controls revealed that there is a significant decrease in anesthetic and opioid requirements (p = 0.024---0.03). Conclusion: Using esmolol during anesthetic maintenance significantly decreases anestheticanalgesic requirements, postoperative pain and PNV.Esmolol; Dor no pós-operatório; Vômito no pós-operatório Efeito da infusão de esmolol sobre a necessidade de anestesia no intraoperatório e analgesia, náusea e vômito no pós-operatório em um grupo de pacientes submetidos à colecistectomia laparoscópica Resumo Objetivo: A dor e a incidência de náusea e vômito no período pós-operatório (NVP) são comuns em pacientes submetidos à colecistectomia laparoscópica. Os agentes simpatolíticos podem diminuir a necessidade de opiáceos ou anestésicos inalatórios ou intravenosos. Neste estudo, nosso objetivo foi analisar os efeitos de esmolol sobre a necessidade de anestésico no período intraoperatório e de analgésico no pós-operatório e a incidência de dor e NVP. Métodos: Sessenta pacientes foram incluídos. Propofol, remifentanil e vecurônio foram usados para a indução. Os grupos de estudo foram os seguintes: grupo I, a infusão de esmolol foi adicionada aos anestésicos (propofol e remifentanil) para manutenção; grupo II, apenas propofol e remifentanil foram usados durante a manutenção; grupo III, a infusão de esmolol foi adicionada aos anestésicos (desflurano e remifentanil) para manutenção; grupo IV, apenas desflurano e remifentanil foram usados durante a manutenção. O período de acompanhamento foi de 24 horas para avaliar a incidência de NVP e a necessidade ...

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Section: Discussionsupporting

confidence: 88%

Effect of intraoperative esmolol infusion on anesthetic, analgesic requirements and postoperative nausea-vomitting in a group of laparoscopic cholecystectomy patients

Dereli

Tutal

Babayiğit

et al. 2015

Brazilian Journal of Anesthesiology (English Edition)

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“…[45] When used as an adjunct, it has been shown to improve the postoperative recovery by reducing postoperative pain intensity and intraoperative anesthetic and opioid requirements and preventing opioid-induced hyperalgesia. [678910111213141516171819202122232425]…”

Section: Introductionmentioning

confidence: 99%

The effect of perioperative esmolol on early postoperative pain: A systematic review and meta-analysis

Watts

Thiruvenkatarajan

Calvert

et al. 2017

J Anaesthesiol Clin Pharmacol

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Esmolol has been shown to improve postoperative pain and reduce opioid requirements. The aim of this systematic review was to evaluate the effect of perioperative esmolol as an adjunct on early postoperative pain intensity, recovery profile, and anesthetic requirement. Databases were searched for randomized placebo-controlled trials evaluating the effects of esmolol during general anesthesia. Primary outcomes were related to early postoperative pain whereas secondary outcomes were related to emergence time, postoperative nausea and vomiting, and intraoperative anesthetic requirement. Nineteen trials were identified involving 936 patients (esmolol = 470, placebo = 466). In esmolol group, numeric pain scores at rest in the immediate postoperative period were reduced by 1.16 (95% confidence interval [CI]: 1.97–0.35, I2 = 96.7%) out of 10. Opioid consumption was also decreased in the postanesthesia care unit compared with placebo, mean difference of 5.1 mg (95% CI: 7.0–3.2, I2 = 96.9%) morphine IV equivalents; a 69% reduction in opioid rescue dosing was noted (odds ratio [OR]: 0.31, 95% CI: 0.16–0.80, I2 = 0.0%). A 61% reduction in postoperative nausea and vomiting was also evident (OR: 0.39, 95% CI: 0.20–0.75, I2 = 60.7%). A reduction in propofol induction dose was noted in the esmolol group (mean difference: −0.53 mg/kg, 95% CI: −0.63–−0.44, I2 = 0.0%). A decrease in end-tidal desflurane equivalent (mean difference: 1.70%, 95% CI: −2.39–−1.02, I2 = 92.0%) and intraoperative opioid usage (fentanyl equivalent, mean difference: 440 μg, 95% CI: −637–−244, I2 = 99.6%) was observed in esmolol group. Esmolol had no effect on the emergence time. Perioperative esmolol as an adjunct may reduce postoperative pain intensity, opioid consumption, and postoperative nausea vomiting. Given the heterogeneity, larger clinical trials are warranted to confirm these findings.

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“…25 30 Moon et al relataram que o uso de esmolol pode diminuir o tempo de permanência na SRPA em pacientes submetidas à cirurgia ginecológica. 6 Neste estudo, observamos que, além de diminuir a necessidade de anestésicos, o esmolol como adjuvante também diminuiu a necessidade de analgésicos e os escores EVA em 24 h de pós-operatório. Alguns estudos anteriores também corroboram nossos achados.…”

Section: Discussionunclassified

“…Esses agentes são opcionais para os opiáceos e também podem diminuir a necessidade de anestésicos intravenosos ou inalatórios. [2][3][4][5][6][7][8] Neste estudo, o nosso objetivo foi avaliar os efeitos de esmolol, antagonista cardiosseletivo de receptores adrenérgicos beta-1, sobre a necessidade de anestesia no intraoperatório e analgesia, dor e náusea e vômito no pós-operatório.…”

Section: Introductionunclassified

Efeito da infusão de esmolol sobre a necessidade de anestesia no intraoperatório e analgesia, náusea e vômito no pós‐operatório em um grupo de pacientes submetidos à colecistectomia laparoscópica

Dereli¹,

Tutal²,

Babayiğit³

et al. 2015

Brazilian Journal of Anesthesiology

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The Sparing Effect of Low-Dose Esmolol on Sevoflurane during Laparoscopic Gynaecological Surgery

Cited by 20 publications

References 32 publications

Effect of intraoperative esmolol infusion on anesthetic, analgesic requirements and postoperative nausea-vomitting in a group of laparoscopic cholecystectomy patients

Effect of intraoperative esmolol infusion on anesthetic, analgesic requirements and postoperative nausea-vomitting in a group of laparoscopic cholecystectomy patients

The effect of perioperative esmolol on early postoperative pain: A systematic review and meta-analysis

Efeito da infusão de esmolol sobre a necessidade de anestesia no intraoperatório e analgesia, náusea e vômito no pós‐operatório em um grupo de pacientes submetidos à colecistectomia laparoscópica

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