SummaryThe gastric acid response and the buffer capacity of the stomach were measured in 30 control subjects and 22 duodenal ulcer patients in response to a masticatory (solid) and a non-masticatory (homogenized) meal having the same chemical composition. The peak acid output values were equal after a masticatory and after a non-masticatory diet in control subjects (masticatory 18-1 ± 1.2, non-masticatory 15-7 ± 1-3 mmol/hr) as well as in duodenal ulcer patients (masticatory 35-7 ± 1P5, non-masticatory 33-7 ± 1