The sonographic imaging of fetal adrenal neuroblastoma; a case report

Pley, E.A.P.; Wouters, E.J.M.; Jong, P.A. de; Tielens, A.G.W.M.; Clermonts, G.J.F.

doi:10.1016/0028-2243(89)90031-2

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…It is of interest to note that no such symptoms appeared in these mothers during a former pregnancy with a healthy child. Two cases of pre-eclampsia were seen by Pley et al [17] and Newton et al [27] in mothers of children with postnatally diagnosed neuroblastoma. No such symptom was seen in our cases.…”

Section: Maternal Findingsmentioning

confidence: 99%

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Prenatal Diagnosis of Congenital Neuroblastoma

et al. 1999

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Objective: Advances in prenatal diagnostics during the last 10 years have enabled the examiner to detect even rare fetal disorders such as fetal tumours. Congenital neuroblastoma is the most frequent solid neoplasm in infancy, with a retroperitoneal cystic or solid mass being a sonographic sign of the conditions. Methods: We present 4 cases of neuroblastoma showing suspicious prenatal ultrasound findings. The investigation comprises detection during pregnancy, typical sonographic signs, as well as the postnatal outcome. In addition, a review of the literature is undertaken with a focus on prenatal sonographic signs of congenital neuroblastomas. Results: In all 4 cases, a cystic tumour was detected during the 3rd trimester of pregnancy by means of B-mode sonography. One boy died of disseminated metastases at the age of 26 months. The other 3 survived after surgery and have remained healthy. Conclusions: The detection of a cystic suprarenal mass is suspicious of a congenital neuroblastoma. The delivery should take place at a perinatal centre.

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Section: Maternal Findingsmentioning

confidence: 99%

“…The association of neuroblastoma with fetal hydantoin syndrome or alcoholic fetopathy has been described as well. Hydantoin probably supports tumour genesis by suppressing T cell functioning [9,17]. Magee et al [12] point out the possible influence of drug treatment during pregnancy on tumour genesis.…”

Section: Associated Syndromesmentioning

confidence: 99%

Prenatal Diagnosis of Congenital Neuroblastoma

et al. 1999

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Prenatally diagnosed neuroblastoma

Acharya

Jayabose

Kogan

et al. 1997

Cancer

161

119

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Prenatally diagnosed neuroblastomas are predominantly adrenal in origin and frequently cystic. The liver is the most common site of dissemination and bone involvement is notably absent. The vast majority of these infants have a favorable stage of disease (I, II, and IV-S) and favorable biologic features, and consequently have an excellent prognosis. Although surgery alone is curative for most patients, a period of observation may avoid surgery in some individuals who may achieve spontaneous regression.

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