Prenatal Diagnosis of Congenital Neuroblastoma

Heling, K. S.; Chaoui, Rabih; Hartung, J.; Kirchmair, Felicita; Bollmann, Rainer

doi:10.1159/000020888

Cited by 22 publications

(4 citation statements)

References 19 publications

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“…Several abdominal and pelvic conditions have been reported to be associated with the development of hydrops fetalis [12]. Though the authors were not able to retrieve any prior report of hydrops fetalis occurring in a patient with immature gastric teratoma, the condition has been documented to be associated with the differential diagnoses considered in this case -meconium peritonitis, mesoblastic nephroma, and neuroblastoma [12][13][14]. Among teratomas, hydrops fetalis has been most commonly reported among patients with sacrococcygeal tumors [4,12,15].…”

Section: Discussionmentioning

confidence: 99%

Hydrops fetalis and neonatal abdominal compartment syndrome continuum from immature gastric teratoma: a case report

Caballes

Dungca

et al. 2020

BMC Pediatr

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Background: Hydrops fetalis as well as abdominal compartment syndrome (ACS) are conditions that are associated with high mortality rates. A rare case of immature gastric teratoma causing fetal hydrops and subsequent ACS is presented. The related pathophysiologic mechanisms are discussed, and the importance of timely recognition and appropriate interventions are highlighted. Case presentation: The male patient was born preterm, weighing 3.9 kg., by Cesarean section. Prior prenatal ultrasounds were normal, but a scan done just before delivery had findings indicating polyhydramnios, fetal ascites, and meconium peritonitis. Upon delivery, the patient had respiratory distress, anasarca and a massively distended abdomen. Resuscitation measures, including ventilatory support, were instituted. Imaging studies showed ascites as well as a large, complex intra-abdominal lesion with calcifications. In the succeeding hours, anuria persisted, anasarca worsened, the abdomen became more distended, and inotrope requirements increased. The occurrence of ACS, from what was presumed to be a retroperitoneal teratoma, was therefore considered. Laparotomy was done on the 28th hour of life, with en bloc excision of a massive tumor and attached section of the greater curvature of the stomach. Passage of urine occurred intra-operatively, and the patient was soon after weaned off inotropes and ventilator support. The histopathologic result was immature gastric teratoma. No chemotherapy was given, and the patient's serum AFP is at normal levels 15 months following surgery. Conclusion: The presence of a massive intra-abdominal lesion can result in the pathophysiologic continuum of hydrops fetalis and neonatal ACS. The early recognition of such an association can enable appropriate expectant management of similarly affected neonates, including emergent decompression laparotomy.

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Section: Discussionmentioning

confidence: 99%

Hydrops fetalis and neonatal abdominal compartment syndrome continuum from immature gastric teratoma: a case report

Caballes

Dungca

et al. 2020

BMC Pediatr

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“…While most patients were International Neuroblastoma Staging system (INSS) stage 1, one patient was INSS stage 4, and five were stage 4S. Although at birth two patients underwent complete resection of stage 1 tumor, one patient experienced lymph node recurrence and the other died due to liver complications 4 . In addition, one patient required chemotherapy because a solid part from the cyst enlarged rapidly and liver metastases appeared after birth.…”

Section: Discussionmentioning

confidence: 99%

“…Although at birth two patients underwent complete resection of stage 1 tumor, one patient experienced lymph node recurrence and the other died due to liver complications. 4 In addition, one patient required chemotherapy because a solid part from the cyst enlarged rapidly and liver metastases appeared after birth. These fi ndings indicate that few prenatally detected cystic neuroblastoma cases are high risk.…”

Section: Discussionmentioning

confidence: 99%

“…With the growing use of ultrasonography (US) during pregnancy, prenatal detection of adrenal tumors has increased 1–3 . Those reports have shown that cystic lesions such as adrenal hemorrhage are difficult to differentiate from cystic neuroblastoma 4–6 . We report herein a case of prenatally detected cystic adrenal neuroblastoma, and present a review of the literature, focusing on diagnosis and management of such cases.…”

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confidence: 97%

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Prenatally detected cystic adrenal neuroblastoma

Horiuchi¹,

Watanabe²,

Miyauchi³

et al. 2008

Pediatrics International

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Prenatal sonographic diagnosis of adrenal neuroblastoma

Grandó¹,

Monteggia²,

Gandara³

et al. 2001

J of Clinical Ultrasound

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Neuroblastoma is the most frequent extracranial solid tumor in childhood, but it is seldom diagnosed prenatally. We report a case of adrenal neuroblastoma identified at 39 weeks' menstrual age and successfully treated by postnatal surgery and chemotherapy. Sonography revealed a hyperechoic mass in the right upper quadrant of the fetal abdomen associated with hydramnios and hydronephrosis. Two days after delivery, the tumor was resected. No metastasis was identified. The infant received 6 cycles of chemotherapy, and at 2 years of age she was well, with no signs of recurrence.

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Prenatal Diagnosis of Congenital Neuroblastoma

Cited by 22 publications

References 19 publications

Hydrops fetalis and neonatal abdominal compartment syndrome continuum from immature gastric teratoma: a case report

Hydrops fetalis and neonatal abdominal compartment syndrome continuum from immature gastric teratoma: a case report

Prenatally detected cystic adrenal neuroblastoma

Prenatal sonographic diagnosis of adrenal neuroblastoma

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