The somatosensory mismatch negativity as a window into body representations in infancy

Shen, Guannan; Weiss, Staci Meredith; Meltzoff, Andrew N.; Marshall, Peter

doi:10.1016/j.ijpsycho.2018.10.013

Cited by 48 publications

(14 citation statements)

References 57 publications

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“…In comparison, there is very little work focusing on the infant oscillatory responses following somatosensory stimulation, with developmental studies instead of focusing on event-related potentials (ERPs) elicited to tactile stimulation. These studies have shown that stimulation of the hands, feet, lips, or face of infants elicits spatial patterns of ERP responses across the scalp that are consistent with the homuncular organization of the somatosensory cortex (Meltzoff et al, , 2019Saby et al, 2015;Shen et al, 2018).…”

Section: Neural Correlates Of Somatosensory Processingmentioning

confidence: 71%

Exploring developmental changes in infant anticipation and perceptual processing: EEG responses to tactile stimulation

Shen

Weiss

Meltzoff

et al. 2021

Infancy

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There is an increasing interest in alpha-range rhythms in the electroencephalogram (EEG) in relation to perceptual and attentional processes. The infant mu rhythm has been extensively studied in the context of linkages between action observation and action production in infancy, but less is known about the mu rhythm in relation to cross-modal processes involving somatosensation. We investigated differences in mu responses to cued vibrotactile stimulation of the hand in two age groups of infants: From 6 to 7 months and 13 to 14 months. We were also interested in anticipatory neural responses in the alpha frequency range prior to tactile stimulation. Tactile stimulation of infants' left or right hand was preceded by an audiovisual cue signaling which hand would be stimulated. In response to the tactile stimulus, infants demonstrated significant mu desynchronization over the central areas contralateral to the hand stimulated, with higher mu peak frequency and greater contralateral mu desynchronization for older infants. Prior to the tactile stimulus, both age groups showed significant bilateral alpha desynchronization over frontocentral sites, which may be indicative of generalized anticipation of an upcoming stimulus.

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Section: Neural Correlates Of Somatosensory Processingmentioning

confidence: 71%

Exploring developmental changes in infant anticipation and perceptual processing: EEG responses to tactile stimulation

Shen

Weiss

Meltzoff

et al. 2021

Infancy

Self Cite

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“…Further studies with larger sample sizes are needed to extend our knowledge about the serotonergic neurochemical mechanisms that underlie tactile deviancy processing as well as its association with bodily awareness and self-experience. Furthermore, it needs to be noted that the somatosensory MMN amplitude as well as the time window of its occurrence can vary depending on body parts stimulated and the type, repetition frequency, and interstimulus interval of stimulation (Kekoni et al 1997;Shinozaki et al 1998;Spackman et al 2007;Shen et al 2018aShen et al , 2018b. Future studies should therefore extend the current results by including stimulation of other body parts and different stimulation protocols.…”

Section: Limitationsmentioning

confidence: 87%

Psilocybin Induces Aberrant Prediction Error Processing of Tactile Mismatch Responses—A Simultaneous EEG–FMRI Study

Duerler¹,

Brem

Fraga-González

et al. 2021

Cerebral Cortex

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As source of sensory information, the body provides a sense of agency and self/non-self-discrimination. The integration of bodily states and sensory inputs with prior beliefs has been linked to the generation of bodily self-consciousness. The ability to detect surprising tactile stimuli is essential for the survival of an organism and for the formation of mental body representations. Despite the relevance for a variety of psychiatric disorders characterized by altered body and self-perception, the neurobiology of these processes is poorly understood. We therefore investigated the effect of psilocybin (Psi), known to induce alterations in self-experience, on tactile mismatch responses by combining pharmacological manipulations with simultaneous electroencephalography–functional magnetic resonance imaging (EEG–fMRI) recording. Psi reduced activity in response to tactile surprising stimuli in frontal regions, the visual cortex, and the cerebellum. Furthermore, Psi reduced tactile mismatch negativity EEG responses at frontal electrodes, associated with alterations of body- and self-experience. This study provides first evidence that Psi alters the integration of tactile sensory inputs through aberrant prediction error processing and highlights the importance of the 5-HT2A system in tactile deviancy processing as well as in the integration of bodily and self-related stimuli. These findings may have important implications for the treatment of psychiatric disorders characterized by aberrant bodily self-awareness.

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“…In addition to location deviance sMMR (e.g., Kekoni et al, 1997;Shinozaki et al, 1998;Akatsuka et al, 2007;Restuccia et al, 2007;Restuccia et al, 2009;Chen, Hämmerer, D'Ostilio, et al, 2014;Strömmer et al, 2014;Strömmer et al, 2017;Tarkka et al, 2016;Naeije et al, 2016Naeije et al, , 2018Shen, Smyk, et al, 2018;Shen, Weiss, et al, 2018;Hautasaari et al, 2019;Xu et al, 2021), a somatosensory mismatch response has been demonstrated in an ignore condition by changes in various other stimulus properties, such as duration (Spackman et al, 2007;Spackman et al, 2010, Butler et al, 2011Chen, Hämmerer, D'Ostilio, et al, 2014;Chen et al, 2018), vibratory frequency (Kekoni et al, 1997;Spackman et al, 2007), and a within-pair inter-stimulus interval of stimulus pairs (Akatsuka et al, 2005) that are not related to spatial location or to the somatotopic organization of SI. Therefore, the present findings concerning the differences between MMR to somatosensory location deviance (existing) and intensity deviance (no significant response found)…”

Section: Discussionmentioning

confidence: 99%

Somatosensory Deviance Detection ERPs and Their Relationship to Analogous Auditory ERPs and Interoceptive Accuracy

Kangas

Vuoriainen

et al. 2022

Journal of Psychophysiology

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Abstract. Automatic deviance detection has been widely explored in terms of mismatch responses (mismatch negativity or mismatch response) and P3a components of event-related potentials (ERPs) under a predictive coding framework; however, the somatosensory mismatch response has been investigated less often regarding the different types of changes than its auditory counterpart. It is not known whether the deviance detection responses from different modalities correlate, reflecting a general prediction error mechanism of the central nervous system. Furthermore, interoceptive functions have been associated with predictive coding theory, but whether interoceptive accuracy correlates with deviance detection brain responses has rarely been investigated. Here, we measured ERPs to changes in somatosensory stimuli’s location and intensity and in sound intensity in healthy adults ( n = 34). Interoceptive accuracy was measured with a heartbeat discrimination task, where participants indicated whether their heartbeats were simultaneous or non-simultaneous with sound stimuli. We found a mismatch response and a P3a response to somatosensory location and auditory intensity changes, but for somatosensory intensity changes, only a P3a response was found. Unexpectedly, there were neither correlations between the somatosensory location deviance and intensity deviance brain responses nor between auditory and somatosensory brain responses. In addition, the brain responses did not correlate with interoceptive accuracy. The results suggest that although deviance detection in the auditory and somatosensory modalities are likely based on similar neural mechanisms at a cellular level, their ERP indexes do not indicate a linear association in sensitivity for deviance detection between the modalities. Furthermore, although sensory deviance detection and interoceptive detection are both associated with predictive coding functions, under these experimental settings, functional relationships were not observed. These results should be taken into account in the future development of theories related to human sensory functions and in extensions of the predictive coding theory in particular.

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The somatosensory mismatch negativity as a window into body representations in infancy

Cited by 48 publications

References 57 publications

Exploring developmental changes in infant anticipation and perceptual processing: EEG responses to tactile stimulation

Exploring developmental changes in infant anticipation and perceptual processing: EEG responses to tactile stimulation

Psilocybin Induces Aberrant Prediction Error Processing of Tactile Mismatch Responses—A Simultaneous EEG–FMRI Study

Somatosensory Deviance Detection ERPs and Their Relationship to Analogous Auditory ERPs and Interoceptive Accuracy

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