The Size, Shape, and Composition Design of Iron Oxide Nanoparticles to Combine, MRI, Magnetic Hyperthermia, and Photothermia

Freis, Barbara; Cotin, Geoffrey; Perton, Francis; Mertz, Damien; Boutry, Sébastien; Laurent, Sophie

doi:10.1002/9781119754725.ch17

Cited by 4 publications

(4 citation statements)

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“…Nevertheless, the understanding of the experimental synthesis parameters enabling the control of their formation is still scarce in literature. [20][21][22] To yield well-defined and monocrystalline magnetic NFs, different high temperature synthesis strategies have already been reported. For example, the so-called thermal decomposition of organometallic compounds (ACAC routes) results in the formation of hydrophobic NFs stable in diverse organic solvents.…”

Section: Introductionmentioning

confidence: 99%

“…As magnetic − and optical properties of NPs directly rely on their size, shape, crystallinity, and chemical composition, the control over the synthesis of NFs is of primary importance. Nevertheless, the understanding of the experimental synthesis parameters enabling the control of their formation is still scarce in the literature. − To yield well-defined and monocrystalline magnetic NFs, different high temperature synthesis strategies have already been reported. For example, the so-called thermal decomposition of organometallic compounds (ACAC routes) results in the formation of hydrophobic NFs stable in diverse organic solvents. , Conversely, polyol-mediated syntheses, historically developed by Fievet et al, , provide hydrophilic NFs highly stable in aqueous media. , To induce the formation of flower-like structures by polyol processes, surfactants can be added in the reactive media or mixtures of different polyols can be used. , The influence of different synthesis parameters (temperature slope and heating time, presence of water in the reaction mixture, nature of polyol solvents, , proportions of iron precursors) on the formation of iron oxide NFs has already been investigated, but a clear overview is still missing.…”

Section: Introductionmentioning

confidence: 99%

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Structure–Property–Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia

et al. 2021

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Magnetite and maghemite multi-core nanoflowers (NFs) synthesized using the modified polyol-mediated routes are to date among the most effective nano-heaters in magnetic hyperthermia (MHT). Recently, magnetite NFs have also shown high photothermal (PT) performances in the most desired second near infra-red (NIR-II) biological window making them attractive in the field of nanoparticle-activated thermal therapies. However, what makes magnetic NFs efficient heating agents in both modalities still remain an open question. In this work, we investigate the role of many parameters of the polyol synthesis on the final NFs size, shape, chemical composition, number of cores and crystallinity. These nanofeatures are later correlated to the magnetic, optical and electronic properties of the NFs as well as their collective macroscopic thermal properties in MHT and PT to find relationships between their structure, properties and function. We evidence the critical role of iron(III) and heating ramps on the elaboration of well-defined NFs with high number of multi-cores. While MHT efficiency is found to be proportional to the average number of magnetic cores within the assemblies, the optical responses of the NFs and their collective photothermal properties depend directly on the mean volume of the NFs (as supported by optical cross sections numerical simulations) and strongly on the structural disorder in the NFs, rather than the stoichiometry. The concentration of defects in the nanostructures, evaluated by photoluminescence and Urbach energy (EU), evidences a switch in the optical behavior for a limit value of EU = 0.4 eV where a discontinuous transition from high to poor PT efficiency is also observed. Keywordsmulti-core iron oxides, nanoflowers, magnetic nanoparticles, magnetic hyperthermia, photothermia, nanothermal agents, thermal therapies distributions histograms, powder XRD diffraction data and Rietveld refinements, XANES data, 57 Fe Mössbauer spectra, SQUID, TGA, ZFC/FC measurements and DLS measurements, ILP values, Python codes, Beer-Lambert plots at 1064 nm, Urbach and Tauc plots, MHT and PT measurements, fluorescence emission spectra and additional tables.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structure–Property–Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia

et al. 2021

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“…By using doping, the magnetic properties of iron oxides also can be increased; therefore, the MRI response is also enhanced. By modifying the shapes and morphology of iron oxides, the photoresponse of iron oxides also could be altered and thus the feasibility of iron oxides for photothermal therapy could be increased . Many more developments could be used to enhance the feasibility of iron oxides in biomedical applications, which we will discuss in the next sections.…”

Section: Basic Understanding Of Iron Oxidesmentioning

confidence: 99%

Crafting Iron Oxides for Next-Generation Biomedical Applications

Amrillah,

Notodidjojo,

Kalimanjaro

et al. 2024

Crystal Growth & Design

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Iron oxides are multifunctional materials that have been extensively explored for many applications, including in novel biomedical applications. However, boosting their ability for biomedical purposes remains a significant challenge. Many strategies have been proposed to increase the feasibility of iron oxides for biomedical applications, such as doping and defect engineering, compositing and decorating, surface and interface engineering, and structure and morphology development. This review focuses on the essential advancements of iron oxides for their implementation in biomedical applications. The discussion starts with the design of iron oxides in biomedical applications, such as drug delivery, heat delivery, contrast agents, biomedical nanorobots, and disease-sensing systems. We also discuss the obstacle of iron oxides in biomedical applications and continue by proposing a plausible strategy to enhance the feasibility of iron oxides in biomedical applications. The provided discussion and perspectives can enrich the information and pave the way to finding strategies to enhance the feasibility of iron oxides in biomedicalrelated applications. We believe that our review also could shed light on how to bring iron oxides close to real implementation for biomedical purposes.

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“…Feraheme, Sinerem, Endorem Feridex, Clariscan, Resovist, and Resovist S Supravist are among the FDA-approved IONPs. [77][78][79][80][81][82] The Nanoparticle and MHT, PTT, PDT For effective local tumor ablation, the MHT utilizes heat generated by an alternating magnetic field (AMF). When magnetic NPs and an external AMF accumulate in the target site, heat is commonly generated.…”

Section: Fda Approved Io-nps and Their Applicationsmentioning

confidence: 99%

Fortification of Iron Oxide as Sustainable Nanoparticles: An Amalgamation with Magnetic/Photo Responsive Cancer Therapies

Rethi,

Liu

et al. 2023

IJN

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Due to their non-toxic function in biological systems, Iron oxide NPs (IO-NPs) are very attractive in biomedical applications. The magnetic properties of IO-NPs enable a variety of biomedical applications. We evaluated the usage of IO-NPs for anticancer effects. This paper lists the applications of IO-NPs in general and the clinical targeting of IO-NPs. The application of IONPs along with photothermal therapy (PTT), photodynamic therapy (PDT), and magnetic hyperthermia therapy (MHT) is highlighted in this review’s explanation for cancer treatment strategies. The review’s study shows that IO-NPs play a beneficial role in biological activity because of their biocompatibility, biodegradability, simplicity of production, and hybrid NPs forms with IO-NPs. In this review, we have briefly discussed cancer therapy and hyperthermia and NPs used in PTT, PDT, and MHT. IO-NPs have a particular effect on cancer therapy when combined with PTT, PDT, and MHT were the key topics of the review and were covered in depth. The IO-NPs formulations may be uniquely specialized in cancer treatments with PTT, PDT, and MHT, according to this review investigation.

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The Size, Shape, and Composition Design of Iron Oxide Nanoparticles to Combine, MRI, Magnetic Hyperthermia, and Photothermia

Cited by 4 publications

References 254 publications

Structure–Property–Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia

Structure–Property–Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia

Crafting Iron Oxides for Next-Generation Biomedical Applications

Fortification of Iron Oxide as Sustainable Nanoparticles: An Amalgamation with Magnetic/Photo Responsive Cancer Therapies

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