The sites of deep vascular schizogony in chloroquine-resistant Plasmodium berghei in mice

Miller, Louis H.; Fremount, Henry N.

doi:10.1016/0035-9203(69)90146-1

Cited by 7 publications

(3 citation statements)

References 4 publications

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“…A low level of sequestration which was suspected in strain AJ was investigated by directly observing perfused tissue sections. Previous workers used organ crushes from infected animals to detect the sites for sequestration in various models for malaria (Miller 1969, Miller, Fremount & Luse 1971, Fremount & Rossan 1974, Desowitz et al 1969, Miller & Fremount 1969. In this study on P. chahaudi it was decided to look for sequestered parasites of strain AJ in perfused organ sections.…”

Section: Discussionmentioning

confidence: 99%

“…The binding of P. fulciparum-infected erythrocytes has been observed in vitro, both with primary cultures of endothelial cells (Udeinya et al 1981) and with other human cell lines (Schmidt et al 1982). Although sequestration does not occur with all species of malaria parasites, the phenomenon has been described in various monkey and rodent malaria models (Miller 1969, Miller & Fremount 1969, Desowitz et al 1969, Fremount & Rossan 1974.…”

Section: Introductionmentioning

confidence: 99%

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Plasmodium chabaudi: a rodent malaria model for in‐vivo and in‐vitro cytoadherence of malaria parasites in the absence of knobs

Cox

Semoff

Hommel

1987

Parasite Immunology

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The ability of Plasmodium chabaudi infected erythrocytes to bind to endothelial cells in vivo and to various murine cell lines in vitro is described. A procedure for the selective recovery of a sequestering subpopulation of schizont-infected erythrocytes from hepatic sinusoids of BALB/c mice, using a combination of body perfusion, trypsin treatment and Percoll density centrifugation was developed. The serial subinoculation of such a subpopulation was used to select for a clone of parasites (strain AJJ) with considerably better cytoadherent characteristics than the parent line (strain AJ). In contrast, it was demonstrated that another clone (PC7), showed no cytoadherence in vivo or in vitro. This study shows that parasite induced alterations occurred on the surface of erythrocytes infected with late developmental stages of P. chabaudi. The antigenicity of these molecules in the infected mouse was demonstrated using immune serum and affinity chromatography. Cytoadherence and surface antigenic changes in P. chabaudi schizont-infected erythrocytes were demonstrated in the absence of the submembranous 'knobs' associated with cytoadherence in P. falciparum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasmodium chabaudi: a rodent malaria model for in‐vivo and in‐vitro cytoadherence of malaria parasites in the absence of knobs

Cox

Semoff

Hommel

1987

Parasite Immunology

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“…Although knob-independent cytoadherence has been documented for immature gametocytes of P. falcißarum (22) and other malaria species, such as P. knowlesi (23), P. berghei (24), and P. chabaudi (25), it has only recently been described for the asexual stages of P. faleiparum (26,27). In both cases described, K-cytoadherent clones were obtained by repeated selection for a minor population of K--infected erythrocytes that bound to melanoma cells .…”

mentioning

confidence: 99%

Knob-independent cytoadherence of Plasmodium falciparum to the leukocyte differentiation antigen CD36.

Biggs

Goozé

Wycherley

et al. 1990

The Journal of Experimental Medicine

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The survival of Plasmodium falciparum-infected erythrocytes is enhanced by the sequestration of mature trophozoites and schizonts from the peripheral circulation. Cytoadherence of infected erythrocytes in vivo is associated with the presence of knobs on the erythrocyte surface, but we and others have shown recently that cytoadherence to C32 melanoma cells may occur in vitro in the absence of knobs. We show here that a knobless clone of P. falciparum adheres to the leukocyte differentiation antigen, CD36, suggesting that binding to CD36 is independent of the presence of knobs on the surface of the infected erythrocyte. This clone showed little cytoadherence to immobilized thrombospondin or to endothelial cells expressing the intercellular adhesion molecule 1. Furthermore, an Mr approximately 300-kD trypsin-sensitive protein doublet was immunoprecipitated from knobless trophozoite-infected erythrocytes. Finding a P. falciparum erythrocyte membrane protein 1 (PfEMP1)-like molecule on these infected erythrocytes is consistent with a role for PfEMP1 in cytoadherence to CD36 and C32 melanoma cells.

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ExperimentalModels of Cerebral Malaria

Engwerda

Belnoue

Grüner

et al. 2005

Current Topics in Microbiology and Immunology

120

111

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The sites of deep vascular schizogony in chloroquine-resistant Plasmodium berghei in mice

Cited by 7 publications

References 4 publications

Plasmodium chabaudi: a rodent malaria model for in‐vivo and in‐vitro cytoadherence of malaria parasites in the absence of knobs

Plasmodium chabaudi: a rodent malaria model for in‐vivo and in‐vitro cytoadherence of malaria parasites in the absence of knobs

Knob-independent cytoadherence of Plasmodium falciparum to the leukocyte differentiation antigen CD36.

ExperimentalModels of Cerebral Malaria

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