The sirtuin 6: An overture in skin cancer

Garcia-Peterson, Liz Mariely; Guzmán-Pérez, Glorimar; Krier, Cassandre R; Ahmad, Nihal

doi:10.1111/exd.14057

Cited by 15 publications

(11 citation statements)

References 73 publications

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“…In the early stages of cancer, autophagy can inhibit tumor growth [11]. However, with the development of cancer, cancer cells show a high degree of autophagy dependence, and autophagy plays a role in promoting the growth of such cells [12]. In addition, autophagy can be used as a prognostic marker for a variety of cancers, while inhibition or activation of autophagy can destroy tumor cells [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

A Novel Autophagy-Related lncRNA Gene Signature to Improve the Prognosis of Patients with Melanoma

Ding

Tayier

et al. 2021

BioMed Research International

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Objective. Autophagy and long noncoding RNAs (lncRNAs) have been the focus of research on the pathogenesis of melanoma. However, the autophagy network of lncRNAs in melanoma has not been reported. The purpose of this study was to investigate the lncRNA prognostic markers related to melanoma autophagy and predict the prognosis of patients with melanoma. Methods. We downloaded RNA sequencing data and clinical information of melanoma from the Cancer Genome Atlas. The coexpression of autophagy-related genes (ARGs) and lncRNAs was analyzed. The risk model of autophagy-related lncRNAs was established by univariate and multivariate Cox regression analyses, and the best prognostic index was evaluated combined with clinical data. Finally, gene set enrichment analysis was performed on patients in the high- and low-risk groups. Results. According to the results of the univariate Cox analysis, only the overexpression of LINC00520 was associated with poor overall survival, unlike HLA-DQB1-AS1, USP30-AS1, AL645929, AL365361, LINC00324, and AC055822. The results of the multivariate Cox analysis showed that the overall survival of patients in the high-risk group was shorter than that recorded in the low-risk group ( p < 0.001 ). Moreover, in the receiver operating characteristic curve of the risk model we constructed, the area under the curve (AUC) was 0.734, while the AUC of T and N was 0.707 and 0.658, respectively. The Gene Ontology was mainly enriched with the positive regulation of autophagy and the activation of the immune system. The results of the Kyoto Encyclopedia of Genes and Genomes enrichment were mostly related to autophagy, immunity, and melanin metabolism. Conclusion. The positive regulation of autophagy may slow the transition from low-risk patients to high-risk patients in melanoma. Furthermore, compared with clinical information, the autophagy-related lncRNA risk model may better predict the prognosis of patients with melanoma and provide new treatment ideas.

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Section: Introductionmentioning

confidence: 99%

A Novel Autophagy-Related lncRNA Gene Signature to Improve the Prognosis of Patients with Melanoma

Ding

Tayier

et al. 2021

BioMed Research International

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“…However, none of them was correlated with patients' survival. SIRT3 and SIRT7 expression was correlated with high proliferation rates in the GCT samples, and these two SIRT family members have also been implicated in different cancers [33][34][35]. With regard to SIRT3, it can be stated that in some types of cancer, SIRT3 appears to function as a tumor promoter.…”

Section: Discussionmentioning

confidence: 99%

Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors

Schmid¹,

Dietrich²,

Forné³

et al. 2021

IJMS

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Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells. KGN cells are an established cellular model for the majority of GCTs and were used to explore the role of SIRT1. The SIRT1 activator SRT2104 increased cell proliferation. By contrast, the inhibitor EX527 reduced cell numbers, without inducing apoptosis. These results were supported by the outcome of siRNA-mediated silencing studies. A tissue microarray containing 92 GCTs revealed nuclear and/or cytoplasmic SIRT1 staining in the majority of the samples, and also, SIRT2-7 were detected in most samples. The expression of SIRT1–7 was not correlated with the survival of the patients; however, SIRT3 and SIRT7 expression was significantly correlated with the proliferation marker Ki-67, implying roles in tumor cell proliferation. SIRT3 was identified by a proteomic analysis as the most abundant SIRT in KGN. The results of the siRNA-silencing experiments indicate involvement of SIRT3 in proliferation. Thus, several SIRTs are expressed by GCTs, and SIRT1 and SIRT3 are involved in the growth regulation of KGN. If transferable to GCTs in situ, these SIRTs may represent novel drug targets.

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“…Over the past decades, SIRT6 has been extensively investigated for its biological functions in diverse life‐threatening human diseases such as cancer, inflammation, diabetes, and neurogenerative disease 4,27,65–69 . In the context of cancer, SIRT6 was considered as a double‐edged sword due to its dual role of both tumor suppression and promotion, depending on the type of tumors (Table 2).…”

Section: Human Diseasesmentioning

confidence: 99%

Emerging roles of SIRT6 in human diseases and its modulators

Liu

Chen

Liu

et al. 2020

Medicinal Research Reviews

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The biological functions of sirtuin 6 (SIRT6; e.g., deacetylation, defatty‐acylation, and mono‐ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene expression, and telomeric maintenance. Over the past decades, the aberration of SIRT6 has been extensively observed in diverse life‐threatening human diseases. In this comprehensive review, we summarize the critical roles of SIRT6 in the onset and progression of human diseases including cancer, inflammation, diabetes, steatohepatitis, arthritis, cardiovascular diseases, neurodegenerative diseases, viral infections, renal and corneal injuries, as well as the elucidation of the related signaling pathways. Moreover, we discuss the advances in the development of small molecule SIRT6 modulators including activators and inhibitors as well as their pharmacological profiles toward potential therapeutics for SIRT6‐mediated diseases.

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The sirtuin 6: An overture in skin cancer

Cited by 15 publications

References 73 publications

A Novel Autophagy-Related lncRNA Gene Signature to Improve the Prognosis of Patients with Melanoma

A Novel Autophagy-Related lncRNA Gene Signature to Improve the Prognosis of Patients with Melanoma

Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors

Emerging roles of SIRT6 in human diseases and its modulators

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