“…SIRT6 can effectively remove the acetyl groups from H3K9, H3K18, and H3K27, whereas its deacetylation activity is weak on H3K4ac, H3K14ac, H3K23ac, H3K36ac, H3K56ac, and H3K79ac ( 37 ). In addition to histones, the substrates of SIRT6 include acetylated lysine residues of other proteins, including GCN5 K549ac, PKM2 K433ac, Ku70 K542ac, NAMPT K53ac/369ac, XBP1s K257/297ac, SOD2 K68/122ac, and p53 K382ac ( 2 ). The catalytic mechanism of SIRT6-mediated enzymatic function has been well reviewed by Fiorentino et al.…”