The Significance of Vascular Invasion and Lymphocytic Infiltration in Invasive Cervical Cancer

Nagell, J.R. van; Donaldson, Elvis S.; Wood, E. G.; Parker, Joseph C.

doi:10.1097/00006254-197807000-00023

Cited by 12 publications

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“…23 Histopathologically, majority of tumours showed few to moderate number of mitotic figures, lymphovascular invasion, lymphoplasmacytic stromal response was moderate to severe. Similar histological findings were observed by Gauthier P et al 24 and van Nagell JR et al 25 The objective of determining tumour grade (degree of differentiation) is to estimate biologic behaviour and aid inpatient management. Extension of SCC into endometrium and/or myometrium, in hysterectomy specimens, focuses attention on the need for a more complete biopsy procedure and pretreatment workup prior to initiation of therapy.…”

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confidence: 79%

Histopathological Catalogue for the Pre-Malignant and Malignant Lesions of Uterine Cervix at a Tertiary Care Centre of Maharashtra

Patil¹,

Patil²,

Khade³

et al. 2020

IJAR

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Introduction: Carcinoma of cervix is the most common cancer in Indian women and is the third largest cause of cancer mortality in India. The transformation zone of the cervix is vulnerable to HPV. A preneoplastic cervical intraepithelial neoplasia can regress, persist or progress towards invasive carcinoma. Aims: To study the prevalence and histopathological spectrum of premalignant and malignant lesions of uterine cervix. Methods: This was a retrospective cross-sectional study, carried out at Tertiary Care Hospital, in Department of Pathology, over a period of one-year. Results:Total 14 cases (8%) of total hysterectomy and 156 cases (92%) of cervical biopsy were included, which included31 cases (18%) premalignant lesions (CIN-I, II, III, CIS) and 139 cases (82%) malignant. SCC was found in 73% cases and adenocarcinoma in 8.3%. Limitations: Follow-up was not possible. Conclusions: Awareness programs and educational sessions might help to reduce the burden of carcinoma cervix in India.

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confidence: 79%

Histopathological Catalogue for the Pre-Malignant and Malignant Lesions of Uterine Cervix at a Tertiary Care Centre of Maharashtra

Patil¹,

Patil²,

Khade³

et al. 2020

IJAR

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“…The importance of the LVSI is somewhat controversial in cervical cancer. LVSI significantly correlates with lymph node metastasis ( 20 ) . Several reports have shown that LVSI was a prognostic determinant in cervical cancer ( 10,20–22 ) but its' significance was denied by the others ( 23 ) .…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in FIGO stage IB cervical cancer without lymph node metastasis and the role of adjuvant radiotherapy after radical hysterectomy

Ayhan¹,

Al²,

Baykal³

et al. 2004

Int J Gynecol Cancer

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“…The degree of stromal inflammatory cell infiltrate was also a significant prognostic factor for recurrence in this study, although its association was less pronounced ( P = 0.04). In the literature, only a few reports have investigated the prognostic significance of this factor in early stage cervical carcinoma 24. Some authors noticed a better outcome when there was a predominance of eosinophilic leukocytes 25.…”

Section: Discussionmentioning

confidence: 99%

Surgical pathologic factors that predict recurrence in stage IB and IIA cervical carcinoma patients with negative pelvic lymph nodes

Samlal

Velden

Kate

et al. 1997

Cancer

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with pelvic lymph node dissection. The study group was composed of 196 lymph node negative patients. Pathology slides were reviewed and multivariate analysis 1 Department of Obstetrics and Gynecology, Acperformed to identify independent prognostic factors. ademic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. RESULTS.The recurrence rate in the study group was 7.7%. In multivariate analysis, the following factors were identified as independent risk factors for recurrence: 2 Department of Pathology, Academic Medical adenocarcinoma (P Å 0.003), depth of invasion as a fraction of tumor penetration Center, University of Amsterdam, Amsterdam, of the cervical stroma (P Å 0.01), and an extensive stromal inflammatory cell The Netherlands.infiltrate (P Å 0.04). Based on these factors, the following risk groups were identi- patterns for these patients showed a predominance of pelvic recurrences.CONCLUSIONS. This study showed that among patients with Stage IB and IIA cervical carcinoma and negative pelvic lymph nodes, a subset with a significant risk for recurrence could be identified. Because the majority of recurrences in the lymph node negative group were pelvic recurrences, the value of adjuvant radiotherapy as a treatment for selected lymph node negative patients should be evaluated in a prospective study.

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The Significance of Vascular Invasion and Lymphocytic Infiltration in Invasive Cervical Cancer

Cited by 12 publications

References 0 publications

Histopathological Catalogue for the Pre-Malignant and Malignant Lesions of Uterine Cervix at a Tertiary Care Centre of Maharashtra

Histopathological Catalogue for the Pre-Malignant and Malignant Lesions of Uterine Cervix at a Tertiary Care Centre of Maharashtra

Prognostic factors in FIGO stage IB cervical cancer without lymph node metastasis and the role of adjuvant radiotherapy after radical hysterectomy

Surgical pathologic factors that predict recurrence in stage IB and IIA cervical carcinoma patients with negative pelvic lymph nodes

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