The significance of immunohistochemical expression of Ki-67, p53, p21, and p16 in meningiomas tissue arrays

Terzi, Ayşen; Saglam, Arzu; Barak, Anil; Söylemezoğlu, Figen

doi:10.1016/j.prp.2008.01.013

Cited by 55 publications

(44 citation statements)

References 38 publications

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“…The anticancer activity of p53 is through several mechanisms: it activates DNA repair proteins, induces growth arrest at the G1/S regulation point through p21 or initiates apoptosis if the DNA damage is irreversible [12]. It has been investigated also in meningioma and several studies showed a positive correlation with the grade and tumour recurrence [4,7,8,14,15,24,26], whereas authors reported the grade as an independent predictive factor of recurrences with high Mib1 and p53 LI being a supportive marker helpful in borderline cases [31].…”

Section: Introductionmentioning

confidence: 99%

Assessment of candidate immunohistochemical prognostic markers of meningioma recurrence

Csonka¹,

Murnyák²,

Szepesi³

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Assessment of candidate immunohistochemical prognostic markers of meningioma recurrence

Csonka¹,

Murnyák²,

Szepesi³

et al. 2016

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“…Many studies confirmed the importance of tumour localisation, proliferative markers like Ki-67, the type of tumour resection and also the specific genetic alterations, for the risk of neoplasm recurrences [1,6,17,18].…”

Section: Discussionmentioning

confidence: 94%

“…Different laboratories estimated Ki-67 mean indices as 0.9-3.8%, 3.3-9.9% and 8.7-14.7%, for meningiomas of grade I, II and III, respectively [1,5,6]. The differences in Ki-67 LI for one histological grade can result from the various methods applied for Ki-67 LI quantisation [2,6,7]. Also, various groups of investigators postulated the different cut-off values of Ki-67 LI related significantly to the increased risk of recurrences.…”

Section: Introductionmentioning

confidence: 99%

New automated image analysis method for the assessment of Ki-67 labeling index in meningiomas.

Grala

Markiewicz²,

Kozłowski³

et al. 2010

Folia Histochem Cytobiol.

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Abstract:Many studies have emphasised the importance of Ki-67 labeling index (LI) as the proliferation marker in meningiomas. Several authors confirmed, that Ki-67 LI has prognostic significance and correlates with likelihood of tumour recurrences. These observations were widely accepted by pathologists, but up till now no standard method for Ki-67 LI assessment was developed and introduced for the diagnostic pathology. In this paper we present a new computerised system for automated Ki-67 LI estimation in meningiomas as an aid for histological grading of meningiomas and potential standard method of Ki-67 LI assessment. We also discuss the concordance of Ki-67 LI results obtained by presented computerized system and expert pathologist, as well as possible pitfalls and mistakes in automated counting of immunopositive or negative cells. For the quantitative evaluation of digital images of meningiomas the designed software uses an algorithm based on mathematical description of cell morphology. This solution acts together with the Support Vector Machine (SVM) used in the classification mode for the recognition of immunoreactivity of cells. The applied sequential thresholding simulated well the human process of cell recognition. The same digital images of randomly selected tumour areas were parallelly analysed by computer and blindly by two expert pathologists. Ki-67 labeling indices were estimated and the results compared. The mean relative discrepancy between the levels of Ki-67 LI by our system and by the human expert did not exceed 14% in all investigated cases. These preliminary results suggest that the designed software could be an useful tool supporting the diagnostic digital pathology. However, more extended studies are needed for approval of this suggestion.

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“…It has been shown that abnormal expression of p16 is associated with several cancers, such as lung, laryngeal, and tonsillary carcinomas [29][30][31]. Various scoring methods have been used in studies comparing p16 expression and prognostic parameters in various neoplasms [32][33][34]. In bladder cancer, there is no consensus about the regarding the p16 staining pattern.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of different p16 immunostaining methods and the prognostic role of p16/Ki-67 combined expression in non-muscle invasive bladder cancers

Özyalvaçlı¹,

Özyalvaçlı²,

Astarci³

et al. 2015

pjp

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The significance of immunohistochemical expression of Ki-67, p53, p21, and p16 in meningiomas tissue arrays

Cited by 55 publications

References 38 publications

Assessment of candidate immunohistochemical prognostic markers of meningioma recurrence

Assessment of candidate immunohistochemical prognostic markers of meningioma recurrence

New automated image analysis method for the assessment of Ki-67 labeling index in meningiomas.

Evaluation of different p16 immunostaining methods and the prognostic role of p16/Ki-67 combined expression in non-muscle invasive bladder cancers

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