The significance of imaging examinations during follow-up for malignant melanoma

Pozsgai, Melánia; Németh, Klára; Oláh, Péter; Gyulai, Rolland; Lengyel, Zsuzsanna

doi:10.1684/ejd.2021.4054

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Recent studies have found that the peak incidence rates of melanoma recurrences and subsequent primary melanomas occur during the first 2-3 years after a melanoma diagnosis. 5,42,44,[46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] Overall, less than 5% of melanoma recurrences occur beyond 5 years after definitive management. 15 However, several studies have suggested that there is an elevated risk of subsequent primary melanomas that persists beyond 10 years after the initial melanoma diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Surveillance After a Previous Cutaneous Melanoma Diagnosis: A Scoping Review of Melanoma Follow-Up Guidelines

Johnston,

Starkey,

Mukovozov

et al. 2023

J Cutan Med Surg

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Introduction Cutaneous melanoma accounts for more than 70% of all skin cancer deaths. Follow-up surveillance is an integral part of melanoma patient care, to facilitate early detection of recurrences and subsequent primary melanomas. The purpose of this scoping review is to provide an overview of recently published melanoma surveillance guidelines from regional and national melanoma working groups. Methods A systematic search for relevant studies in MEDLINE and Embase was conducted in September 2022 and was limited to publications from 2010 or later. Results A total of 1047 articles were retrieved, and after abstract and full text review, 26 articles from 19 different organizations met inclusion criteria. Life-long annual skin surveillance with a physician was recommended by 53% (9/17) of guidelines. Routine laboratory investigations were recommended by 7/19 guidelines. Regional lymph node ultrasound was recommended by 9/16 guidelines, most often in stage IB or higher, and was optional in 7/16 for patients who met specific criteria. Surveillance with PET-CT or CT and MRI was recommended by 15 and 11 guidelines, respectively, most commonly in stage IIC or higher, with a variable frequency and total duration. Five out of 9 guidelines indicated a preference for skin surveillance to be completed with a dermatologist. Conclusion Guidelines were highly variable for many aspects of melanoma surveillance, which may be partly attributed to regional differences in healthcare workforce distribution and availability of imaging technologies. Further high-level studies are recommended to provide more evidence on the most effective clinical and imaging follow-up surveillance protocols.

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Section: Discussionmentioning

confidence: 99%

Surveillance After a Previous Cutaneous Melanoma Diagnosis: A Scoping Review of Melanoma Follow-Up Guidelines

Johnston,

Starkey,

Mukovozov

et al. 2023

J Cutan Med Surg

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“…Today, there is a growing need for blood biomarkers to monitor high risk patients or those with metastatic melanoma in order to improve survival. Of course, from stage IIB of melanoma, initial and regular follow-up imaging examinations are warranted and preferably computed using tomography scans [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Combining Biomarkers for the Diagnosis of Metastatic Melanoma

Várvölgyi,

Janka,

Szász

et al. 2023

JCM

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The early detection of melanoma relapse can improve patient survival; thus, there is a great need for easily accessible biomarkers that facilitate the diagnosis of metastatic disease. We investigated the diagnostic effect of blood biomarkers such as lactate dehydrogenase (LDH), S100B, and osteopontin in the detection of metastases. Clinical data and peripheral blood samples of 206 melanoma patients were collected (no metastasis, N = 120; metastasis, N = 86). The discriminative power of blood biomarkers, patient demographics, and clinicopathological parameters of primary melanomas were evaluated using univariate and multivariate logistic regression models and receiver operating characteristic (ROC) analysis to determine the area under the curve (AUC). Plasma osteopontin levels showed a significant and independent effect on the probability of metastasis, similar to serum S100B levels. In addition, the location of the primary tumor on the lower extremities and the American Joint Committee on Cancer (AJCC) categories pT2b-3a, pT3b-4a, and pT4b were associated with the diagnosis of metastasis. Importantly, the combination of the three blood biomarkers and primary tumor localization and AJCC pT category yielded excellent discrimination (AUC: training set: 0.803; validation set: 0.822). In conclusion, plasma osteopontin can be classified as a melanoma biomarker; moreover, by combining clinicopathological prognostic variables, the diagnostic effect of blood biomarkers in the detection of metastatic melanoma can be improved.

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“…Mobile students, in most cases (unless they earn some form of scholarship), pay for their education, which is an important income source for HEIs in host countries [35], [36], [37]. Their living expenses (accommodation fees, travel, food, and various services) are an important part of the local economy's income [21], [38]. Cray et al highlight that students enrolling in HE already have some perceptions of teaching and learning processes, based on their previous educational experiences [39].…”

Section: Student Mobility In Europementioning

confidence: 99%

There is Nothing Like a DREEM to Create the Future of Medical Education: International and Hungarian Medical and Dentistry Students’ Perceptions on their Learning Environment in Hungary

Dávidovics

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In the last decades of the 20th century, student mobility has significantly increased worldwide. Tuition fees paid by international students have become a crucial part of university revenue, compelling higher education institutions to compete with each other. Global rankings of the best universities have emerged, and the growing influx of international students has transformed the student population at many institutions. In Hungary, the number of international students is most significant at the four medical schools: in Budapest, Debrecen, Pécs, and Szeged. International students come from various countries, with diverse cultural backgrounds, varied experiences, educational needs, and expectations. This raises the following questions: To what extent do Hungarian medical schools meet the expectations of international and Hungarian students? Are international students satisfied with medical and dental education, when compared with their Hungarian peers? The aim of the research was to comprehensively examine the opinions of international and Hungarian medical and dentistry students, studying at the four Hungarian medical schools, regarding their learning environment. This encompassed all aspects of their studies, from the actual physical environment to teaching methods, their own professional knowledge, and social networks. Based on the results, it can be concluded that, while international and Hungarian medical and dentistry students were generally satisfied with the learning environment at the four medical schools in Hungary, significant differences were observed among those enrolled in the Hungarian, German, and English programmes. This highlights areas where further development could enhance the quality and international recognition of medical and dental education in Hungary.

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The significance of imaging examinations during follow-up for malignant melanoma

Cited by 6 publications

References 31 publications

Surveillance After a Previous Cutaneous Melanoma Diagnosis: A Scoping Review of Melanoma Follow-Up Guidelines

Surveillance After a Previous Cutaneous Melanoma Diagnosis: A Scoping Review of Melanoma Follow-Up Guidelines

Combining Biomarkers for the Diagnosis of Metastatic Melanoma

There is Nothing Like a DREEM to Create the Future of Medical Education: International and Hungarian Medical and Dentistry Students’ Perceptions on their Learning Environment in Hungary

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