The significance of IL-1β +3953C&gt;T, IL-6 -174G&gt;C and -596G&gt;A, TNF-α -308G&gt;A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation

Szpecht, Dawid; Gadzinowski, Janusz; Nowak, Irmina; Cygan, Dorothy; Seremak‐Mrozikiewicz, Agnieszka; Kurzawińska, Grażyna; Madajczak, Dariusz; Drews, Krzysztof; Szymankiewicz, Marta

doi:10.5114/ceji.2017.67000

“…G replaces C and the C allele has a protective function because it is associated with a lower secretion of IL‐6 37 . The CC homozygous causes a lower production of IL‐6 38 . The possible presence of this polymorphism in these patients could also explain the different results in the studies.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of IL‐6 levels and +3954 polymorphism of IL‐1β in burning mouth syndrome: A systematic review and meta‐analysis

Campello

¹

,

Pellizzer

²

,

Vasconcelos

³

et al. 2020

J Oral Pathology Medicine

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This study evaluated IL‐6 salivary levels as well as the +3954 polymorphism of IL‐1β in patients with burning mouth syndrome and healthy individuals, through case‐control studies. This systematic review and meta‐analysis followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. We conducted this research in PubMed/MEDLINE, Cochrane Library and Web of Science databases. The risk of bias was measured based in the Newcastle‐Ottawa Scale. Researches with a group of patients with burning mouth syndrome and a control group in which the presence of the +3954 polymorphism of IL‐1β and/ or IL‐6 salivary levels through non‐stimulated saliva were evaluated to detect if this interleukin concentrations are increased in patients and if the polymorphism is a risk factor for this syndrome. We identified seven studies with total of 440 participants, 229 patients with burning mouth syndrome and 211 healthy controls, ages 24‐84 years old. The female gender was predominant. Patients in the majority of studies did not present increased levels of IL‐6 and the +3954 polymorphism of IL‐1β is not a risk factor for this syndrome. A few studies researched biomarkers in this pathology and more investigations are required not only to identify salivary levels and the polymorphism evaluated, but also other interleukins and polymorphisms in order to clarify the etiopathogenesis of this syndrome as well as for propose new diagnostic methods and treatments.

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“…In BPD infants, IL-1 β , IL-6, TNF- α , and IL-10 cytokine levels were altered in the amniotic fluid [ 16 ], cord blood [ 17 ], and tracheal aspirate samples [ 2 ]. TNF- α single nucleotide polymorphisms could predict BPD onset and severity in preterm neonates [ 18 ]. Ehrhardt et al reported that TNF- α in tracheal aspirate samples was associated with BPD severity [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Cytokines and Exhaled Nitric Oxide Are Risk Factors in Preterm Infants for Bronchopulmonary Dysplasia

Zhang

¹

,

Wu

²

,

Hou

³

et al. 2021

BioMed Research International

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Bronchopulmonary dysplasia (BPD) is the most common complication of extremely preterm birth. This study was aimed at detecting cytokine and fractional exhaled nitric oxide (FeNO) levels to evaluate their mechanisms and predicted significance for BPD. Preterm infants born at g e s t a t i o n a l a g e ≤ 32 w e e k s were recruited, and clinical data were collected. We detected ten cytokines, including IFN-γ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, and TNF-α on Days 1–3, Days 7–14, and Days 21–28 after birth by using the Meso Scale Discovery (MSD) technology. The FeNO levels of infants were measured when they met the discharge criteria. A total of 46 preterm infants were enrolled, consisting of 14 infants in BPD group and 32 infants in the control group. The gestational age ( 27.5 ± 1.3 vs. 29.9 ± 1.3 weeks) and birth weight ( 1021 ± 261 g vs. 1489 ± 357 g) were lower in the BPD group. The following were high-risk factors for BPD, as determined by multivariate logistic regression analysis: g e s t a t i o n a l a g e < 30 w e e k s , b i r t h w e i g h t < 1000 g , PDA, longer mechanical ventilation, and higher FeNO. The cytokines of IL-6 and IL-8 on Days 7–14 and IL-4, IL-6, IL-8, and TNF-α on Days 21–28 were also high-risk factors for BPD. IL-6 contributed to BPD disease severity. Conclusion. The preterm infants with PDA and prolonged mechanical ventilation tended to develop BPD. The IL-6 and IL-8 were significantly increased on Days 7–14 and were high-risk factors for BPD. Moreover, the IL-6 level was associated with BPD disease severity. We speculated that NO was related to BPD via Th2 cell-mediated inflammatory responses such as IL-4 and IL-6. Cytokines might predict the occurrence of BPD.

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“…Our study found that the cytokines IL-1β, IL-4, IL-6, IL-8, and TNF-α were increased in the BPD group on days 14–28 significantly, whereas IL-10 was decreased. In the previous study, IL-1β, IL-6, TNF-α, and IL-10 cytokine levels were altered in the amniotic fluid ( Yoon et al, 1997 ), cord blood ( Rocha et al, 2012 ), and tracheal aspirate samples ( Yilmaz et al, 2017 ) in BPD infants ( Szpecht et al, 2017 ). Therefore, we speculated that these cytokines may be related to the lung injury of BPD infants.…”

Section: Discussionmentioning

confidence: 91%

The Change of Cytokines and Gut Microbiome in Preterm Infants for Bronchopulmonary Dysplasia

Zhang

¹

,

Jiang

²

,

Li

³

et al. 2022

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BackgroundBronchopulmonary dysplasia (BPD) is a devastating form of chronic lung disease that develops in preterm infants. BPD is speculated to arise from abnormal inflammatory responses, which is related to the composition of commensal microbiota, leading us to hypothesize that BPD susceptibility could be influenced by gut microbiota through inflammatory responses. This study is aimed to detect cytokines and the differences in fecal gut microbial composition in the BPD patients.MethodsBetween June 2018 and June 2020, preterm infants born at gestational age ≤30 weeks were recruited. The clinical data of infant characteristics were collected. On days 3–7 and 14–28 after birth, fresh stool samples and serum were collected. The gut microbiota composition between the BPD group and controls was detected by 16S rRNA sequencing. On days 3–7 and days 14–28, ten cytokines including IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, IFN-γ, and TNF-α were detected in the serum.ResultsThis study enrolled 38 preterm infants; the number of preterm infants in the BPD group and control group was, respectively, 18 and 20. The gestational age (27.4 ± 1.5 weeks vs. 29.5 ± 0.9 weeks, p = 0.000) and birth weight (971 ± 240 g vs. 1262 ± 335 g, p = 0.000) of the BPD group were lower than those of the control group. The present study found that the BPD group had high levels of IL-1β, IL-4, IL-6, IL-8, and TNF-α, whereas IL-10 was decreased. The Shannon diversity index of the BPD group was lower. The relative abundances of Proteobacteria in BPD group increased significantly from days 3–7 to days 14–28, while the Firmicutes was decreased. On days 14–28, the relative abundances of Proteobacteria in BPD group were significantly higher than those in the control group, while the Firmicutes was lower.ConclusionBronchopulmonary dysplasia could be influenced by gut microbiota through inflammatory responses. More studies are needed to explore the imbalance of cytokines and microbiome in BPD infants and whether it could be reversed by probiotics. This study provided a novel perspective for treating BPD.

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The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation

Cited by 7 publications

References 34 publications

Evaluation of IL‐6 levels and +3954 polymorphism of IL‐1β in burning mouth syndrome: A systematic review and meta‐analysis

Evaluation of IL‐6 levels and +3954 polymorphism of IL‐1β in burning mouth syndrome: A systematic review and meta‐analysis

Cytokines and Exhaled Nitric Oxide Are Risk Factors in Preterm Infants for Bronchopulmonary Dysplasia

The Change of Cytokines and Gut Microbiome in Preterm Infants for Bronchopulmonary Dysplasia

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