The significance of FDG uptake in bilateral thyroid glands

Chen, Yen Kung; Cheng, Ru Hwa; Yeh, Chun Ting; Lee, Chin Cheng; Hsu, Chia-Hsiang

doi:10.1097/mnm.0b013e328013eaf7

Cited by 39 publications

(37 citation statements)

References 14 publications

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“…Accumulation of 18 F-FDG in normal thyroid tissue is usually low to absent because free fatty acids are preferred substrates for the thyroid gland (17). Diffuse thyroid uptake is generally regarded as benign and results from inflammatory etiologies, such as thyroiditis (18). Fibroblast infiltration also leads to continuous uptake of 18 F-FDG after treatment in patients with chronic thyroiditis (10).…”

Section: Discussionmentioning

confidence: 99%

“…Diffuse thyroid uptake is generally regarded as benign and results from inflammatory etiologies, such as thyroiditis (18). Fibroblast infiltration also leads to continuous uptake of 18 F-FDG after treatment in patients with chronic thyroiditis (10). Tateishi et al (7) reported that diffuse thyroid uptake in patients with advanced breast cancer represents active inflammation caused by chronic thyroiditis.…”

Section: Discussionmentioning

confidence: 99%

“…These findings have led to investigations of the interaction between autoimmune thyroid disorders and breast cancer. 18 F-FDG PET CT is a useful imaging modality for detecting recurrences and for monitoring treatment outcome in various cancers, including breast cancer (5). In daily practice, incidental thyroid uptake of 18 F-FDG in PET/CT is often encountered (6).…”

mentioning

confidence: 99%

“…18 F-FDG PET CT is a useful imaging modality for detecting recurrences and for monitoring treatment outcome in various cancers, including breast cancer (5). In daily practice, incidental thyroid uptake of 18 F-FDG in PET/CT is often encountered (6). Patients with breast cancer have a relatively high prevalence of this condition (7), probably because they have a high prevalence of thyroid disorders (8,9).…”

mentioning

confidence: 99%

“…Thus, this study was conducted to determine whether incidental diffuse uptake of 18 F-FDG in the thyroid may have a good prognostic value in the outcomes of breast cancer patients.…”

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confidence: 99%

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Incidental Diffuse Thyroid ¹⁸F-FDG Uptake Related to Autoimmune Thyroiditis May Be a Favorable Prognostic Factor in Advanced Breast Cancer

Kim

et al. 2012

J Nucl Med

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Patients with breast cancer have a relatively high prevalence of diffuse thyroid uptake of 18 F-FDG related to thyroid autoimmunity. It is postulated that the presence of thyroid autoimmunity has prognostic implications for breast cancer. The aim of this study was to evaluate the prognostic value of incidental diffuse thyroid uptake in breast cancer patients. Methods: This was a retrospective observational cohort study in a tertiary referral hospital. We evaluated a total of 564 patients who had undergone surgery for primary breast cancer between January 2006 and December 2009. Patients were divided into 2 groups according to their diffuse thyroid uptake. The main outcome measure was disease-free survival. Results: Of the 564 patients, 108 (19.1%) showed diffuse thyroid uptake. The median follow-up period was 36.0 mo (range, 1.0-77.0 mo). Both thyroperoxidase and thyroglobulin antibody titers were higher in patients with thyroid uptake than in those without (P , 0.001 for both). Of the 108 patients with thyroid uptake, 5 had a recurrence of breast cancer during the follow-up, whereas 85 without uptake had a recurrence (log-rank statics, 12.28; P , 0.001). The association between diffuse thyroid uptake and tumor recurrence was not significant in multivariate analysis of patients with early-stage breast cancer (hazard ratio, 0.26; 95% confidence interval, 0.06-1.10; P 5 0.067). However, the association between diffuse thyroid uptake and breast cancer recurrence was statistically significant in multivariate analysis with adjustment for several prognostic variables (hazard ratio, 0.19; 95% confidence interval, 0.57-0.62; P 5 0.006). Conclusion: Incidental diffuse thyroid uptake related to autoimmune thyroiditis was an independently favorable prognostic factor in advanced breast cancer. These findings support evidence that thyroid autoimmunity has a beneficial effect on the outcomes of breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

“…Thus, this study was conducted to determine whether incidental diffuse uptake of 18 F-FDG in the thyroid may have a good prognostic value in the outcomes of breast cancer patients.…”

mentioning

confidence: 99%

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