The Significance of Family History in First-Episode Schizophrenia Spectrum Disorder

Norman, Ross; Manchanda, Rahul; Malla, Ashok; Harricharan, Raj; Northcott, Sandra

doi:10.1097/nmd.0b013e318156f8e2

Cited by 17 publications

(12 citation statements)

References 51 publications

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“…The results are consistent with the hypothesized relationships and with previous research showing that positive FH is associated with worse premorbid adjustment, poorer social functioning, higher levels of attention problems, and higher illness severity (St-Hilaire et al, 2005; Norman et al, 2007; Walshe et al, 2007). The cross-sectional data shows that compared to adolescents without FH, those with positive FH in the present study had higher scores on the individual scales Thought Problems, Delinquent Behavior, and Aggressive Behavior at baseline and on the composite scale Externalizing Problems at one year follow-up.…”

Section: Discussionsupporting

confidence: 91%

“…Another family study comparing patients with and without FH of schizophrenia found FH to be associated with worse premorbid adjustment related to attention problems and social problems (St-Hilaire et al, 2005). A third study with similar design examined differences in the premorbid adjustment, symptoms, and intellectual functioning between 28 first-episode schizophrenia spectrum patients (with diagnoses of schizophrenia, schizoaffective, and schizopreniform disorders) with positive FH and 28 matched patients without FH (Norman et al, 2007). The patients with positive FH showed poorer intellectual functioning, less reduction in clinical symptoms at 24 and 36 months follow-up, and more severe form of the illness.…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal investigation of the relationship between family history of psychosis and affective disorders and Child Behavior Checklist ratings in clinical high-risk adolescents

Simeonova

Lee

Walker

2015

Schizophrenia Research

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This is the first study to investigate whether positive family history (FH) of psychosis and affective disorders moderates the relationship between child diagnostic status and parent-reported social and behavioral problems on the Child Behavior Checklist (CBCL) in clinical high-risk adolescents. This longitudinal investigation assessed 122 participants (mean age = 14.25 ± 1.8 years) from three groups (at-risk, other personality disorders, non-psychiatric controls) at baseline and one year follow-up. As predicted, there was a main effect of FH for a number of CBCL scales indicating higher scores for adolescents with positive FH. The findings also demonstrate a significant Diagnostic Status X Family History interaction for several behavioral scales providing support for FH as a concurrent and longitudinal moderator of the relationship between diagnostic status and CBCL scales. The moderating effect is present for areas of functioning associated with depression, anxiety, social adjustment, thought problems, attention problems, and aggressive behavior. The findings also indicate that both positive and negative symptoms are related to the genetic vulnerability for developing psychosis in clinical high-risk individuals, particularly those symptoms reflective of emotional, attentional, and interpersonal functioning. The present findings are novel and have significant clinical and research implications. This investigation provides a platform for future studies to clarify further the role of FH in clinical high-risk individuals and contribute to integration of this knowledge in the development of early intervention and prevention approaches in at-risk populations for the emergence of severe mental illness.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Longitudinal investigation of the relationship between family history of psychosis and affective disorders and Child Behavior Checklist ratings in clinical high-risk adolescents

Simeonova

Lee

Walker

2015

Schizophrenia Research

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“…This is consistent with the conclusion that there are few robust neurocognitive differences between schizophrenia patients with and without relatives affected by psychosis [21,22]. However, Norman and colleagues found higher IQ scores in patients without affected relatives [18]. …”

Section: Introductionsupporting

confidence: 88%

“…Schizophrenia patients with only one affected relative also have impaired IQ scores compared to healthy controls [14] as well as unaffected subjects with one first- or second-degree relative with schizophrenia [15–17]. Only a few studies (n=56-154 subjects) have compared IQ scores between schizophrenia patients with and without relatives affected by psychosis [18–20]. Interestingly, most of these studies did not detect a difference between full scale IQ scores for patients with or without affected relatives in the family [19,20].…”

Section: Introductionmentioning

confidence: 99%

The Association between Intelligence Scores and Family History of Psychiatric Disorder in Schizophrenia Patients, Their Siblings and Healthy Controls

Verweij

Derks

Risk³

et al. 2013

PLoS ONE

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BackgroundThe degree of intellectual impairment in schizophrenia patients and their relatives has been suggested to be associated with the degree of familial loading for schizophrenia. Since other psychiatric disorders are also more present in relatives of schizophrenia patients, the definition of family history should be broadened. The association between family history for psychiatric disorder and intelligence scores was investigated in patients with non-affective psychosis, their unaffected siblings and controls.MethodsA sample of 712 schizophrenia proband families (696 patients and 766 siblings) and 427 healthy control families (517 subjects) participated in this study. Family history of psychiatric disorder was determined while excluding the data of the participating schizophrenia patient. A dichotomous division was made between families with no first- or second degree relative with psychiatric disorder and families with one or more affected relatives. Total intelligence scores were estimated by admission of the short form of the Wechsler Adult Intelligence Scale III.ResultsA significant interaction was found between family history of psychiatric disorder and clinical status (F(2,1086.87)= 4.17; p=.016). Patients with a positive family history of psychiatric disorder obtained higher intelligence scores compared to patients with no family history (mean IQ scores are 95.52 and 92.72) with an opposite effect in controls (mean IQ scores are 108.71 and 111.19). No significant difference was found between siblings of schizophrenia patients with or without a positive family history (mean IQ scores are 102.98 and 103.24).ConclusionIn patients with schizophrenia, a negative family history of psychiatric disorder was associated with relatively low IQ suggesting that the etiology in these patients may involve environmental or genetic factors which are unique to the patient and are not observed in other relatives. Possible factors include severe environmental stressors containing premature birth or brain injury and genetic factors (e.g de novo Copy Number Variants).

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“…r The association of EEG abnormalities with familiarity for schizophrenia remains controversial [10,13].…”

Section: Eeg Findings and Familiarity For Schizophreniamentioning

confidence: 99%

EEG in Psychoses, Mood Disorders and Catatonia

Boutros

Galderisi²,

Pogarell

et al. 2011

Standard Electroencephalography in Clinical Psychiatry

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The Significance of Family History in First-Episode Schizophrenia Spectrum Disorder

Cited by 17 publications

References 51 publications

Longitudinal investigation of the relationship between family history of psychosis and affective disorders and Child Behavior Checklist ratings in clinical high-risk adolescents

Longitudinal investigation of the relationship between family history of psychosis and affective disorders and Child Behavior Checklist ratings in clinical high-risk adolescents

The Association between Intelligence Scores and Family History of Psychiatric Disorder in Schizophrenia Patients, Their Siblings and Healthy Controls

EEG in Psychoses, Mood Disorders and Catatonia

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