The significance of elevated plasma creatine phosphokinase activity in muscle disease of cattle

Anderson, Peter H.; Berrett, Sylvia; Patterson, D.S.P.

doi:10.1016/0021-9975(76)90062-1

Cited by 35 publications

(19 citation statements)

References 12 publications

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“…The higher concentrations of above serum enzymes are not unusual and are in close agreement with the findings of Pemberton et al • (1974), Keller (1974) and Anderson et al (1976) in bovines. Injury to muscles and/or liver invariably result in increased values of these enzymes (Mouthon and Magat 1976;Anderson et al 1976) and the present cases were no exception in respect of muscle damage, both to skeletal and, to little extent, to cardiac. The increased CPK, AST and LDH levels were apparently related with muscle damage and the increased AL T values appeared to be due to the hepatic damage as suggested by the earlier workers (Pemberton et al 1974) and also proven on histopathological examination.…”

Section: B) Biochemical Changessupporting

confidence: 80%

Haematological and Biochemical Alterations in Hill Bulls Infected with Clostridium chauvoei

Singh¹,

Parihar²,

Charan³

et al. 1993

Acta Vet. Brno

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Section: B) Biochemical Changessupporting

confidence: 80%

Haematological and Biochemical Alterations in Hill Bulls Infected with Clostridium chauvoei

Singh¹,

Parihar²,

Charan³

et al. 1993

Acta Vet. Brno

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“…Increased CK activities are usually associated with muscular dystrophy or exercise (Anderson 1976;Anderson et al 1976). …”

Section: Discussionmentioning

confidence: 99%

Biochemical and Haematological Values in Venous Blood of Farmed Red Deer (Cervus elaphus) at High Altitude

Padilla¹,

Bouda²,

Quiroz-Rocha³

et al. 2000

Acta Vet. Brno

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Red deer, venous blood, biochemical values, haematology, high altitudeIn recent years red deer has been farmed in Mexico. Some biochemical and haematological analytes have been described in this species, however, their values depend mainly on nutrition, management and environmental conditions. Biochemical and haematological values are important for monitoring of health status and diagnosis of diseases. Great differences were described in values of plasma analytes, especially in concentrations of Na + and K + in red deer ( W ilson and Pauli 1983;Knox et al. 1988;Hargreaves and Matthews 1995).The objective of this study was to determine biochemical and haematological values in venous blood of farm red deer in central Mexico at the altitude of 2 450 m. Materials and MethodsBlood biochemical values were determined in 30 red deer (Cervus elaphus) (15 males, 15 females) and haematological values in 60 animals (30 males and 30 females) aged 5 months, average body mass 53.9 kg without clinical signs of disease. The animals were kept on pasture in the Valley of central Mexico at the altitude of 2 450 m. The climate was moderate, rainy during summer, with average temperature between 5 and 14 °C. The pasture was composed of rye grass, orchard, kikuyo, white clover and alfalfa. Daily calculated dry matter consume was 2.06 kg per animal. During sampling the animals without sedation were gently restrained in standing position, in a small pen, with covered eyes and plugged ears.Samples of blood were taken from jugular vein into plain tubes for biochemical analyses, into tubes containing EDTA k3 for haematological analyses and in syringes previously coated with 2 per cent heparin Na for determination of acid-base values. The air bubbles were expelled from the syringe immediately after blood collection and then the needle was inserted into a rubber stopper to prevent exposure of sample to air. The sealed syringes after collection were immersed in a mixture of ice and water.

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“…Similar to other active behaviours, voluntary walking is more likely to be exhibited by calves that are not in pain. Both assisted and unassisted birth has been demonstrated to result in increased serum creatine kinase concentration in calves in the immediate postpartum period (Anderson et al, 1976;Knowles et al, 2000;Murray et al, 2015) and more severe assistance has been associated with higher concentration (Murray et al, 2015). As creatine kinase is a muscle specific enzyme, elevated serum concentrations of this enzyme in cattle are considered an indicator of muscle damage (Anderson et al, 1976;Russell and Roussel, 2007), which is likely to be a source of pain and discomfort.…”

Section: Discussionmentioning

confidence: 99%

A single dose of ketoprofen in the immediate postpartum period has the potential to improve dairy calf welfare in the first 48 h of life

Gladden

Ellis

Martin

et al. 2019

Applied Animal Behaviour Science

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The welfare impact of birth on newborn calves has rarely been studied. Dystocia in particular may have significant welfare costs for calves. While analgesia is sometimes provided to calves born to difficult parturition by veterinary surgeons in practice, it is not known if this is actually beneficial. On a commercial dairy farm, we examined the behavioural time budget of 39 Holstein heifer calves born with the aid of farmer assistance and 36 calves born without assistance; half of each group were randomly allocated to receive either a single dose of the non-steroidal anti-inflammatory drug ketoprofen or a saline placebo in a two by two factorial design. The calves were group housed and their behaviour was recorded for 48 hours postpartum and analysed using instantaneous focal sampling (every 5 minutes in alternate hours). Regardless of analgesic treatment, calves born with assistance showed behaviours consistent with experiencing a less positive welfare state (lying with their head down and in lateral recumbency, and less time playing than unassisted calves). Behavioural differences between calves treated with ketoprofen and calves treated with saline (in particular increased play) suggest that the birth experience may be painful for all calves, even if no assistance is required. Our findings suggest that a single dose of ketoprofen in the immediate postpartum period may improve calf welfare regardless of assistance status and has the potential to contribute to significant welfare gains in dairy calves.

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The significance of elevated plasma creatine phosphokinase activity in muscle disease of cattle

Cited by 35 publications

References 12 publications

Haematological and Biochemical Alterations in Hill Bulls Infected with Clostridium chauvoei

Haematological and Biochemical Alterations in Hill Bulls Infected with Clostridium chauvoei

Biochemical and Haematological Values in Venous Blood of Farmed Red Deer (Cervus elaphus) at High Altitude

A single dose of ketoprofen in the immediate postpartum period has the potential to improve dairy calf welfare in the first 48 h of life

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