The significance of different health institutions and their respective contributions of active pharmaceutical ingredients to wastewater

Herrmann, Manuel; Olsson, Oliver; Fiehn, Rainer; Herrel, Markus; Kümmerer, Klaus

doi:10.1016/j.envint.2015.07.020

Cited by 58 publications

(19 citation statements)

References 42 publications

(67 reference statements)

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“…The PTPs from tests with initial lower concentrations showed faster formation/elimination kinetics than those formed at higher concentrations. This agrees with other finding in the literature (Herrmann et al, 2015;Mahmoud et al, 2014). It was observed that even PTPs that continuously increased over time during photolysis at higher concentrations, behaved differently at lower concentrations, increasing up to a certain time point and then decreasing.…”

Section: Identification Of Dmi Ptps and Proposed Degradation Pathwaysupporting

confidence: 92%

“…The second is the fact that more intermediates and PTPs were formed in response to irradiation with UV light at higher initial concentrations. These intermediates can compete with DMI and absorb UV light partially before the UV light can pass through the entire solution (Herrmann et al, 2015).…”

Section: Dmi Photodegradation Using Different Concentrations: Eliminamentioning

confidence: 99%

“…TCAs are much used in many countries such as Germany, Spain, and Austria. Their consumption has shown a steady increase during recent years (Bauer et al, 2008;Herrmann et al, 2015). This study focus on desipramine (DMI), which belongs to the TCA group and it is an example of the commonly used TCAs (Boonprasert et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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UV-photodegradation of desipramine: Impact of concentration, pH and temperature on formation of products including their biodegradability and toxicity

Khaleel

Olsson

Kümmerer

2016

Science of The Total Environment

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Section: Identification Of Dmi Ptps and Proposed Degradation Pathwaysupporting

confidence: 92%

Section: Dmi Photodegradation Using Different Concentrations: Eliminamentioning

confidence: 99%

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UV-photodegradation of desipramine: Impact of concentration, pH and temperature on formation of products including their biodegradability and toxicity

Khaleel

Olsson

Kümmerer

2016

Science of The Total Environment

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“…The highest individual mean concentration observed was for DIC 233 ng L −1 ; however, the maximum concentration regarded CIP, 14 mg L −1 . This high value, along with others that are completely offset, were observed in the effluents of pharmaceutical industries and hospitals [25,26,111,183].…”

Section: Wastewater Effluentsmentioning

confidence: 74%

Selected Pharmaceuticals in Different Aquatic Compartments: Part I—Source, Fate and Occurrence

et al. 2020

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Potential risks associated with releases of human pharmaceuticals into the environment have become an increasingly important issue in environmental health. This concern has been driven by the widespread detection of pharmaceuticals in all aquatic compartments. Therefore, 22 pharmaceuticals, 6 metabolites and transformation products, belonging to 7 therapeutic groups, were selected to perform a systematic review on their source, fate and occurrence in different aquatic compartments, important issues to tackle the Water Framework Directive (WFD). The results obtained evidence that concentrations of pharmaceuticals are present, in decreasing order, in wastewater influents (WWIs), wastewater effluents (WWEs) and surface waters, with values up to 14 mg L−1 for ibuprofen in WWIs. The therapeutic groups which presented higher detection frequencies and concentrations were anti-inflammatories, antiepileptics, antibiotics and lipid regulators. These results present a broad and specialized background, enabling a complete overview on the occurrence of pharmaceuticals in the aquatic compartments.

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“…These pollutants can enter the environment through various routes, including the direct discharge of sewage from health institutions, industries, agriculture, aquaculture, and households [1,2]. On the other hand, wastewater treatment plants (WWTPs) are unable to completely remove pharmaceutical compounds, and thus their effluents are also sources of these compounds in aquatic systems [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Enantiomeric Separation of Tramadol and Its Metabolites: Method Validation and Application to Environmental Samples

et al. 2017

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Abstract:The accurate assessment of racemic pharmaceuticals requires enantioselective analytical methods. This study presents the development and validation of an enantioselective liquid chromatography with a fluorescence detection method for the concomitant quantification of the enantiomers of tramadol and their metabolites, N-desmethyltramadol and O-desmethyltramadol, in wastewater samples. Optimized conditions were achieved using a Lux Cellulose-4 column 150 × 4.6 mm, 3 µm isocratic elution, and 0.1% diethylamine in hexane and ethanol (96:4, v/v) at 0.7 mL min −1 . The samples were extracted using 150 mg Oasis ® mixed-mode cation exchange (MCX) cartridges. The method was validated using a synthetic effluent of a laboratory-scale aerobic granular sludge sequencing batch reactor. The method demonstrated to be selective, accurate, and linear (r 2 > 0.99) over the range of 56 ng L −1 to 392 ng L −1 . The detection and the quantification limits of each enantiomer were 8 ng L −1 and 28 ng L −1 for tramadol and N-desmethyltramadol, and 20 ng L −1 and 56 ng L −1 for O-desmethyltramadol. The feasibility of the method was demonstrated in a screening study in influent and effluent samples from a wastewater treatment plant. The results demonstrated the occurrence of tramadol enantiomers up to 325.1 ng L −1 and 357.9 ng L −1 , in the effluent and influent samples, respectively. Both metabolites were detected in influents and effluents.

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The significance of different health institutions and their respective contributions of active pharmaceutical ingredients to wastewater

Cited by 58 publications

References 42 publications

UV-photodegradation of desipramine: Impact of concentration, pH and temperature on formation of products including their biodegradability and toxicity

UV-photodegradation of desipramine: Impact of concentration, pH and temperature on formation of products including their biodegradability and toxicity

Selected Pharmaceuticals in Different Aquatic Compartments: Part I—Source, Fate and Occurrence

Enantiomeric Separation of Tramadol and Its Metabolites: Method Validation and Application to Environmental Samples

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