The significance of coagulation and fibrinolysis-related parameters in predicting postoperative venous thrombosis in patients with breast cancer

Pang, Mengyu; Zhao, Fangyuan; Yu, Pengyue; Zhang, Xiaohua; Xiao, Hexin; Wang, Qiang; Zhu, Hongquan; Zhao, Lei

doi:10.21037/gs-21-117

Cited by 7 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tian et al found that after performing pulmonary surgery, patients with postoperative VTE had significantly higher D-Dimer preoperatively and at postoperative day 1 and day 3 than non-VTE patients [ 28 ]. In breast cancer, it has been shown that D-Dimer is significantly increased in patients with DVT after radical breast cancer surgery [ 29 ]. In our study, D-Dimer was significantly higher in VTE patients than in non-VTE patients at preoperative and postoperative day 3, which were 550.18 ± 357.71 vs. 279.58 ± 225.54, P = 0.028; 1564.77 ± 672.11 vs. 809.31 ± 443.35, P = 0.014, respectively.…”

Section: Discussionmentioning

confidence: 99%

Predictive factors on postoperative venous thromboembolism after minimally invasive colorectal cancer surgery: a retrospective observational study

Tang

et al. 2023

BMC Surg

View full text Add to dashboard Cite

Background Venous thromboembolism (VTE) is a serious and preventable postoperative complication. However, the predictive significance of perioperative biochemical parameters for VTE after minimally invasive colorectal cancer surgery remains unclear. Methods A total of 149 patients undergoing minimally invasive colorectal cancer surgery were collected between October 2021 and October 2022. Biochemical parameters related to preoperative and postoperative day 1, day 3, and day 5 were collected, including D-Dimer, mean platelet volume (MPV), and maximum amplitude (MA) of thromboelastography (TEG). Receiver operating characteristic (ROC) curves were used to explore the predictive powers of meaningful biochemical parameters for postoperative VTE, and calibration curves were used to assess predictive accuracy. Results The overall cumulative incidence of VTE was 8.1% (12/149). The preoperative and postoperative day 3 D-Dimer, postoperative day 3, and day 5 MPV, and postoperative day 1, day 3, and day 5 TEG-MA was significantly higher in the VTE group than in the non-VTE group (P < 0.05). The results of both the ROC curve and the calibration curve indicated that these meaningful D-Dimer, MPV, and TEG-MA had moderate discrimination and consistency for postoperative VTE. Conclusions D-Dimer, MPV, and TEG-MA may predict postoperative VTE in patients undergoing minimally invasive surgery for colorectal cancer at specific times in the perioperative period.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictive factors on postoperative venous thromboembolism after minimally invasive colorectal cancer surgery: a retrospective observational study

Tang

et al. 2023

BMC Surg

View full text Add to dashboard Cite

show abstract

“…Thrombomodulin (TM) is a 74 kDa transmembrane receptor abundantly expressed on the endothelium [10] with functional roles in coagulation, inflammation, and carcinogenesis [11]. The effects of TM activity in cancer correlate to its regulatory roles in anticoagulation, anti-inflammation, tissue adhesion, and proliferation [12][13][14][15][16]. Although initial studies demonstrated TM as an anticoagulant, recent studies have revealed that TM may play a different role in inflammatory processes and tumor progression [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

The Role of Thrombomodulin in Estrogen-Receptor-Positive Breast Cancer Progression, Metastasis, and Curcumin Sensitivity

et al. 2023

View full text Add to dashboard Cite

Estrogen and estrogen receptors (ER) play a key role in breast cancer progression, which can be treated with endocrine therapy. Nevertheless, resistance to endocrine therapies is developed over time. The tumor expression of thrombomodulin (TM) is correlated with favorable prognosis in several types of cancer. However, this correlation has not yet been confirmed in ER-positive (ER+) breast cancer. This study aims to evaluate the role of TM in ER+ breast cancer. Firstly, we found that lower TM expression correlates to poor overall survival (OS) and relapse-free survival (RFS) rates in ER+ breast cancer patients through Kaplan–Meier survival analysis (p < 0.05). Silencing TM in MCF7 cells (TM-KD) increased cell proliferation, migration, and invasion ability. Additionally, TM-KD MCF7 cells showed higher sensitivity (IC50 15 μM) to the anti-cancer agent curcumin than the scrambled control cells. Conversely, overexpression of TM (TM-over) in T47D cells leads to decreased cell proliferation, migration, and invasion ability. Furthermore, TM-over T47D cells showed more resistance (IC50 > 40 μM) to the curcumin treatment. The PI staining, DAPI, and tunnel assay also confirmed that the curcumin-induced apoptosis in TM-KD MCF7 cells was higher (90.34%) than in the scrambled control cells (48.54%). Finally, the expressions of drug-resistant genes (ABCC1, LRP1, MRP5, and MDR1) were determined by qPCR. We found that the relative mRNA expression levels of ABCC1, LRP1, and MDR1 genes after curcumin treatment were higher in scrambled control cells than in TM-KD cells. In conclusion, our results demonstrated that TM plays a suppressive role in the progression and metastasis of ER+ breast cancer, and it regulates curcumin sensitivity by interfering with ABCC1, LRP1, and MDR1 gene expression.

show abstract

Role of Fibrinolytic Mechanisms in Breast Cancer Diagnosis, Prognosis, and Treatment

Qazi

Akhtar

Saeed

et al. 2022

Breast Cancer: From Bench to Personalized Medicine

View full text Add to dashboard Cite

The significance of coagulation and fibrinolysis-related parameters in predicting postoperative venous thrombosis in patients with breast cancer

Cited by 7 publications

References 26 publications

Predictive factors on postoperative venous thromboembolism after minimally invasive colorectal cancer surgery: a retrospective observational study

Predictive factors on postoperative venous thromboembolism after minimally invasive colorectal cancer surgery: a retrospective observational study

The Role of Thrombomodulin in Estrogen-Receptor-Positive Breast Cancer Progression, Metastasis, and Curcumin Sensitivity

Role of Fibrinolytic Mechanisms in Breast Cancer Diagnosis, Prognosis, and Treatment

Contact Info

Product

Resources

About