The significance of cadherin for cell–cell interactions and cell adhesions on biomaterials

Hu, Xingyou; Shen, Gaotian; Hu, Tao; Guan, Guoping; Wang, Lu

doi:10.1080/01694243.2015.1018731

Cited by 4 publications

(8 citation statements)

References 70 publications

(86 reference statements)

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“…Results of scanning electron microscopy revealed that the width of the parallel grooves produced by the plasma treatment was increased following treatment with C (250 W) for 5 min compared with that on samples A (150 W), B (200 W) or D (300 W). Although it has been reported that such increases in grooves can allow increased cell adhesion and promote cell‐cell interactions, under the influence of fluid flow, the cellular phospholipid bilayer structure would initiate cell movement within the groove along with the direction of flow thereby weakening the potential for cell adhesion to the surface of the material. When compared with C (250 W), the grooves on the surfaces of samples B (200 W) and D (300 W) were more narrow and dense, which can, in part, increase the capacity for cell contact, and thus adhesion, to the surface of the materials.…”

Section: Resultsmentioning

confidence: 99%

Use of an in vitro dynamic culture system to assess flow shear forces upon cell adhesion within different structures

Shen

et al. 2018

J of Chemical Tech & Biotech

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BACKGROUND: The perennial problems associated with long-term patency of small diameter vascular grafts have yet to be satisfactorily resolved. One approach to rectify this problem is a rapid endothelialization on the inner wall of the grafts, which could significantly reduce inflammation or hyperplasia. Two critical factors that can affect this process in vivo include that of the biocompatibility of the materials and adhesion strength of cells on its surfaces. Thus, an important area of investigation involves an evaluation of cell adhesion on biomaterials in a dynamic culture system, but only limited research has been directed at examining the relationship between the shear forces resulting from flow rates and cell adhesion on the surface of materials. In this study, an in vitro dynamic culture system was utilized for use in examining such relationship by changing the flow rates. RESULTS: Cells adherent on monofilaments were dislodged with a shear force of 5.4 dyn, while most cells adherent on multifilaments tolerated shear forces of 7.0 dyn. CONCLUSION: Priority rankings of materials could be generated as a function of the shear forces tested, and the design or application of artificial blood vessel materials for use within specific regions of the body could be optimized.

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Section: Resultsmentioning

confidence: 99%

Use of an in vitro dynamic culture system to assess flow shear forces upon cell adhesion within different structures

Shen

et al. 2018

J of Chemical Tech & Biotech

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“…Results from prior research have demonstrated that a hydrophilic surface on a material may be beneficial for cell adhesion and proliferation. 9,35 Moreover, the pore size, pore structure, material's permeability, and physical/chemical properties not only impact cell proliferation but also can control the direction of cell growth, as has been demonstrated in an artificial nerve guide conduit. 36 It is well known that hydrophilicity/hydrophobicity can be influenced by the surface chemistry, while the roughness ratio and topological structure can also influence the wettability of the surface.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, a considerable amount of effort has been directed at improving the biocompatibility of biomaterials in order to reduce such complications. Some examples of these attempts have included a layer by layer assembly, surface grafting and alterations in surface morphology . Ranella et al, utilized the microstructure of nanosilicon materials as an approach to impact cell adhesion.…”

Section: Introductionmentioning

confidence: 99%

“…Some examples of these attempts have included a layer by layer assembly, surface grafting and alterations in surface morphology. [3][4][5][6][7][8][9] Ranella et al, 5 utilized the microstructure of nanosilicon materials as an approach to impact cell adhesion. With the use of a femtosecond laser, they produced silicon wafers with different surfaces that varied from smooth to very coarse.…”

Section: Introductionmentioning

confidence: 99%

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PCL films of varying porosity influence ICAM‐1 expression of HUVECs

Shen

et al. 2016

J Biomedical Materials Res

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Here, we investigate the relationship between the expression of intercellular adhesion molecule-1 (ICAM-1) and the adhesion of human umbilical vein endothelial cells (HUVECs) on a poly-ε-caprolactone (PCL) film with micropores of different pore sizes. The results showed that surface hydrophilicity increased with larger pore sizes, while surfaces became less hydrophilic as the pore size decreased. The ability for adhesion and proliferation of HUVECs on surfaces with larger pore sizes was enhanced as compared with that of surfaces with smaller pore sizes or a flat film. Furthermore, levels of mICAM-1 were increased and sICAM-1 decreased as a function of increasing pore size. These findings demonstrate that film surfaces with larger pore sizes may promote cell adhesion and proliferation and lead to increases in expression of mICAM-1. Thus, we conclude that the pore size of the material's surface exerts a significant impact on the expression of adhesion molecules, the expression of which can represent an important new marker for investigating cell-surface adhesion and proliferation. Moreover, as elevated levels of sICAM-1 are associated with conditions such as inflammation, thrombosis, cerebral infarct and other diseases in vivo, it may serve as an early-warning risk marker when using medical biomaterials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2775-2784, 2016.

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“…Cell adhesion always begins with adhesion of the extracellular matrix (ECM), which plays an important role in the regulation of cell‐cell interaction and cell‐surface adhesion . Nonetheless, when using biomaterials, this process can oftentimes be influenced by the structure of the textile material.…”

Section: Introductionmentioning

confidence: 99%

Control of weft yarn or density improves biocompatibility of PET small diameter artificial blood vessels

Guan

et al. 2017

J Biomed Mater Res

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Polyethylene glycol terephthalate (PET) fabrics with woven structures have proved to be quite effective for use on large diameter artificial blood vessels. However, their use within small-diameter artificial blood vessels has been associated with poor long-term patency, a problem resulting from slow endothelialization on PET and an over hyperplasia of smooth muscle cells. Previous research from our laboratory has revealed that ICAM-1 can be used as a marker to investigate cell adhesion, an effect which was closely associated with cell behavior on the surface of polycaprolactone (PCL) films. Moreover, we found that the coarseness or pore size of the surface exerts considerable influence on cell adhesion and proliferation on PCL films. In this study, we successfully fabricated six types of PET woven fabrics with varying gradients of tightness and porosities. Levels of ICAM-1 expression (membrane ICAM-1 & soluble ICAM-1) were then determined in these woven fabrics. Our results show that increased levels of mICAM-1 and decreased levels of sICAM-1 expression were obtained in HUVECs seeded on these six samples. These findings indicate that cell adhesion and proliferation on fabric surfaces were strongly influenced by their structural parameters, in particular the initial adhesion between the cell and fabric surface. In addition, we also found that extracellular matrix adhesion tends to prefer flat and tight surfaces, which promotes cell-cell and cell-matrix interactions, as well as the endothelialization on the surface of PET fabrics. These findings provide some novel insights with regard to the design and application of small-diameter artificial blood vessels. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 954-964, 2018.

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The significance of cadherin for cell–cell interactions and cell adhesions on biomaterials

Cited by 4 publications

References 70 publications

Use of an in vitro dynamic culture system to assess flow shear forces upon cell adhesion within different structures

Use of an in vitro dynamic culture system to assess flow shear forces upon cell adhesion within different structures

PCL films of varying porosity influence ICAM‐1 expression of HUVECs

Control of weft yarn or density improves biocompatibility of PET small diameter artificial blood vessels

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