The significance of CA125 levels in patients with chronic congestive heart failure. Correlation with clinical and echocardiographic parameters

Abstract

Objective: To assess serum levels of carbohydrate antigen 125 (CA125) in patients with chronic congestive heart failure (CHF) and to assess any correlation with clinical symptoms and echocardiographic indices. Patients and methods: We enrolled 77 male patients (mean age: 73F10 years) admitted to the Cardiology Emergency Department (ED) with cardiac symptoms requiring hospitalization. Diagnosis of CHF was based upon medical history or initial echocardiographic evaluation on current admission. Serum CA125 was measured by an enzyme immunoradiometric assay, on admission and before discharge. Results: The median overall CA125 value was 22.4 (11.5-48.9) U/ml. Serum CA125 levels were related to the severity of CHF [New York Heart Association (NYHA) class I: 19.2 (7.2-31) U/ml, NYHA class II: 17.6 (10-23) U/ml, NYHA class III: 32 (25-77) U/ml and NYHA class IV: 34.3 (18.6-77) U/ml ( pb0.04)]. Patients in NYHA classes III and IV had significantly higher mean values of CA125, than patients in class II ( pb0.005 and pb0.05, respectively). Moreover, patients with fluid congestion (pulmonary congestion, ankle edema) had higher levels of serum CA125 than patients without congestion ( p=0.002 and pb0.03, respectively). Finally, levels of serum CA125 correlated weakly with right ventricular systolic pressure (RVSP) and renal function, while no significant correlation was found between CA125 and E wave deceleration time on Doppler echocardiography, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), liver function and the medical treatment prescribed. Conclusion: Serum CA125 is associated with the clinical severity of CHF and the symptoms and signs of fluid congestion and therefore may be a useful additional tool for the evaluation and clinical staging of these patients.

Cancer antigen 125 level is determined by tricuspid regurgitation among patients with stable systolic heart failure

“…CA-125 was suggested as an emerging marker of poor survival in this group of patients [13]. However, those studies also included those with acute decompositions, which could disable accurate reasoning in the setting of acute congestion, which is known to influence CA-125 level [14]. Besides, RV dilatation and tricuspid regurgitation were not separated from other potential confounders.…”

CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis

“…Subsequent studies found CA 125 levels to be elevated in patients with chronic CHF compared with healthy controls. [17][18][19] Kouris et al 18 demonstrated an association between CA 125 levels and the clinical severity of chronic CHF as well as a weak correlation between CA 125 levels and pulmonary artery pressure. In a recent study, it was .…”

Cancer Antigen 125 is Associated with Length of Stay in Patients with Acute Heart Failure

“…The prolongation of hospitalization through the use of positive inotropic agents is an expected result, yet prolonged hospitalization in the absence of β-blockers and diuretics could arise from poor clinical conditions or poor prognosis. Recent studies 12,[14][15][16] have shown that CA-125, long useful as a tumor marker, has prognostic importance in many cardiovascular diseases, especially HF. In studies related to HF, CA-125 values correlated with pulmonary artery pressure, pulmonary artery capillary wedge pressure, left atrial volume index, LVEF, brain natriuretic peptide values, New York Heart Association functional class, and pericardial effusion.…”

“…11 However, in the last decade, a correlation between serum CA-125 levels and cardiopulmonary diseases such as left-and rightsided HF, coronary artery disease, atrial fibrillation (AF), and chronic obstructive pulmonary disease (COPD), has been revealed. [12][13][14][15][16][17][18][19] Although serum CA-125 levels are significantly increased in HF and this increase correlates with the severity of the disease, the relationship between CA-125 and length of stay (LOS) in patients with HF has not yet been evaluated. This study is the first that attempts to evaluate the relationship between the duration of hospitalization and CA-125 levels in patients with HF.…”