Cancer antigen 125 level is determined by tricuspid regurgitation among patients with stable systolic heart failure

Abstract

Aim. Cancer antigen 125 (CA-125) is a soluble glycoprotein with high molecular weight. Recently, increased serum CA-125 levels were also documented in patients with heart failure (HF). We aimed to show what factors influence serum levels of CA-125 among patients with chronic systolic HF. Method. Patients, who had chronic systolic HF with echocardiographically determined ejection fraction (EF) <45% were enrolled into final analysis (n=56). CA-125 levels were classified into two as those with normal (<35 U/mL) and high levels (≥35 U/mL). Results. Patients with Right ventricular (RV) dilatation had significantly higher CA-125 levels compared to those without RV dilatation. Besides, patients with RV dilatation had higher systolic pulmonary artery pressure (SPAP) levels compared to those without. Patients with high CA-125 levels had more frequent RV dilatation, higher pulmonary artery pressure, more severe tricuspid regurgitation. Tricuspid regurgitation was the only significant predictor of high CA-125 levels in patients with stable chronic systolic HF. Conclusion. It was shown in this study that tricuspid regurgitation was the only independent predictor of high CA-125 levels among patients with chronic stable systolic HF.