The Significance of Brucellar Agglutinins in Human Sera

Gray, Jonathan

doi:10.1128/jb.25.4.415-431.1933

J Bacteriol

1933

DOI: 10.1128/jb.25.4.415-431.1933

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The Significance of Brucellar Agglutinins in Human Sera

Jonathan Gray

Abstract: warrants further search for evidence of the infection in this country. In the serological diagnosis, however, difficulties may arise through repeated failure even late in the disease to demonstrate agglutinins in the sera of individuals proved to be infected by the isolation of the brucella (Burnet, 1924; Carpenter, Boak and Chapman, 1929), and through the agglutinative effects frequently shown by the sera of individuals who give neither clinical evidence nor history of undulant infection (Sedg-

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The Vernes Test for the Diagnosis of Tuberculosis in Dairy Cattle An Investigation on its Applicability

Mattick¹,

Christian²

1934

J. Hyg.

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(With 1 Chart) INTRODUCTION IN a series of publications issued from the Institut Prophylactique in Paris, Vernes and his co-workers (1926) described a flocculation method for the diagnosis of tuberculosis in man. This method was first elaborated for the diagnosis of syphilis. Various modifications were then introduced and it was found that the test could be applied to the diagnosis of human tuberculosis. Finally a standard technique was laid down. This consisted of measuring by means of the Vernes-Bricq-Yvon photometer the amount of flocculation which took place during 4 hours' incubation at 20°C. when 0-6 c.c. of resorcinol (1-25 per cent.) was added to an equal volume of the blood serum under test. Readings were taken immediately the resorcinol was added and again at the end of the incubation period. The difference between these readings gave the value on which the diagnosis was made. If this were below 30 the serum was considered normal. Values over 30 indicated infection, the higher the number the more advanced the infection. Correlation of these figures with clinical examination showed that very frequently the photometer value confirmed the clinical findings, and that in some cases the course of the disease could be forecast and followed by testing a number of blood samples over a period. Boyer and Placidi (1931) reported that, using the identical technique described by Vernes for human tuberculosis, it had been possible to diagnose with a high degree of accuracy tuberculosis in bovine animals. Values of over 30 were recorded in 80 per cent. of the tuberculous sera tested, whilst in 77 per cent. of the normal sera the readings were less than 10.The diagnosis of tuberculosis in cattle in this country depends almost entirely upon the tuberculin test in one or other of its forms. This test is known to give good results where the disease is well developed, but where the case is a border-line one the results are often misleading. The doubtful reactor is therefore a problem in tuberculin-tested herds, and any test which could give definite information in such cases would be extremely valuable. In view of the excellent results reported by Boyer and Placidi, it was decided to investigate the Vernes test in this respect.The importance of testing only authentic sera was realised at the outset. Three groups were therefore set up and only sera which belonged strictly to one of these were used.

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The Vernes Test for the Diagnosis of Tuberculosis in Dairy Cattle An Investigation on its Applicability

Mattick¹,

Christian²

1934

J. Hyg.

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The Significance of Brucellar Agglutinins in Human Sera

Cited by 1 publication

References 22 publications

The Vernes Test for the Diagnosis of Tuberculosis in Dairy Cattle An Investigation on its Applicability

The Vernes Test for the Diagnosis of Tuberculosis in Dairy Cattle An Investigation on its Applicability

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