The Significance of Blood Lipid Alterations in Diabetes Mellitus

New, Maria I.; Roberts, Thomas N; Bierman, Edwin L.; Reader, George G.

doi:10.2337/diab.12.3.208

Cited by 153 publications

(13 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Higher levels of lipids have been found in patients with retinopathy than in those without [1,, suggesting that they may play a part in its development, but other workers have been unable to confirm this relationship [11][12][13][14][15][16]. These discrepancies may have been due to inadequate matching of patient groups for age and treatment type and failure to take into account the effect of renal impairment on plasma lipids [11. There is significant diurnal variation of plasma cholesterol in diabetic subjects [17,18] which might also obscure such an association.…”

mentioning

confidence: 89%

Low density lipoprotein cholesterol: An association with the severity of diabetic retinopathy

et al. 1982

View full text Add to dashboard Cite

Summary. Diurnal profiles of total and lipoprotein cholesterol and triglycerides were measured in 11 insulin-dependent diabetic subjects without retinopathy, 10 with background and 10 with proliferative retinopathy. The groups were closely matched for age and duration of diabetes. Total cholesterol levels were higher in patients with proliferative (5.6_+ 0.5mmol/1) than background (5.1 + 0.7mmol/1) or no retinopathy (4.6_+ 0.8mmol/1, trend test; p < 0.003), due to raised levels of low density lipoprotein (LDL) cholesterol (3.8 _+ 0.9, 3.2 + 0.6 and 2.8 + 0.8mmol/1 respectively; p < 0.02). High density lipoprotein (HDL) levels were similar in patients with and without retinopathy and HDL/ LDL ratios were lower with more severe retinopathy (p < 0.025). Cholesterol levels were similar in diabetic subjects without retinopathy and in 12 normal subjects. Triglyceride levels were not related to retinopathy and no measure of plasma lipids correlated with HbA~ or 24-h mean plasma glucose. Total and LDL cholesterol were weakly inversely correlated with creatinine clearance but the association with retinopathy was independent of this effect.

show abstract

mentioning

confidence: 89%

Low density lipoprotein cholesterol: An association with the severity of diabetic retinopathy

et al. 1982

View full text Add to dashboard Cite

show abstract

“…Hypertriglyceridemia of varying degrees is frequently seen in untreated diabetes mellitus; it is almost the rule in severe insulin deficiency with ketoacidosis (19)(20)(21)(22). Treatment with insulin or oral antidiabetic agents returns elevated plasma TG to or toward normal indicating that absolute or relative lack of endogenous insulin may be a cause of diabetic hypertriglyceridemia.…”

Section: Introductionmentioning

confidence: 99%

Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal- and diet-induced activity.

Pykälistö¹,

Smith²,

Brunzell³

1975

J. Clin. Invest.

280

106

View full text Add to dashboard Cite

A B S T R A C T The role of insulin in the regulation of human adipose tissue lipoprotein lipase was evaluated. Adipose tissue heparin-releasable lipoprotein lipase (thought to be related to peripheral clearance of plasma triglycerides) was low in insulin-deficient, untreated hyperglycemic diabetic subjects (P <0.001) and treatment of hyperglycemia returned the activity to normal. In chronic hyperinsulinism, represented by obesity, heparin-releasable activity among control subjects was correlated to percent of ideal body weight (r = 0.53, P < 0.05) and to fat cell size (r = 0.61, P < 0.02).Acetone-ether powder lipoprotein lipase activity (presumed to reflect total tissue enzyme) was also related to percent of ideal body weight (r = 0.76, P < 0.001 for controls; r = 0.67, P <0.05 for diabetics) and to fat cell size (r = 0.71, P <0.01 for controls; r = 0.85, P <0.01 for diabetics. Postprandial-stimulated insulin secretion was related to diet-induced changes in lipoprotein lipase in control subjects; both were dependent upon the amount of dietary carbohydrate. In contrast, the diabetic patients with low insulin responses, failed to increase lipoprotein lipase activity with feeding. The changes in heparin-releasable (r = 0.66, P <0.01) and acetone-ether powder (r = 0.69, P <0.01) activity during feeding were related to the percent increase in plasma insulin.Thus, insulin appears to be important in the regulation of human adipose tissue lipoprotein lipase activity. Elevated insulin levels in obesity and increased insulin secretion after eating were associated with increased lipoprotein lipase activity. Defects in insulin secretion, both in postabsorptive and postprandial states, are asThis study represents a part of the clinical investigation by the late Dr. Olavi J. Pykdlist6 during a fellowship at the Veterans Administration Hospital in Seattle, Wash.

show abstract

“…There was a statistically significant increase of triglycerides and total lipid in the young diabetics with vascular disease when compared to those young diabetics without vascular disease (p < 0.001) or the normal control group (p < 0.001) with comparative body build and age. New et al 29 observed, elevation of triglycerides in the presence of complications only after the age of thirty years but not before. Cholesterol fraction was no different whether complications were present or not.…”

Section: Discussionmentioning

confidence: 97%

Interrelationship of Vascular Disease and Blood Lipids in Young Indian Diabetics

et al. 1969

View full text Add to dashboard Cite

Clinical and laboratory data on 100 young diabetic patients in a North Indian urban population were obtained to determine the prevalence of vascular disease and its relation to certain clinical factors. The findings revealed evidence of vascular disease in 32 per cent of young diabetics as retinopathy (15.0 per cent), coronary artery disease (myocardial infarction and angina pectoris, 14 per cent) and nephropathy (10 per cent). Duration of disease, dietary habits, or the mode of treatment and control of diabetes did not appear to be related to the development of vascular disease. Total serum lipid content and triglycerides were elevated in those who manifested clinically objective vascular disease.

show abstract

The Significance of Blood Lipid Alterations in Diabetes Mellitus

Cited by 153 publications

References 2 publications

Low density lipoprotein cholesterol: An association with the severity of diabetic retinopathy

Low density lipoprotein cholesterol: An association with the severity of diabetic retinopathy

Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal- and diet-induced activity.

Interrelationship of Vascular Disease and Blood Lipids in Young Indian Diabetics

Contact Info

Product

Resources

About