Low density lipoprotein cholesterol: An association with the severity of diabetic retinopathy

Dornan, Timothy; Carter, R. D.; Bron, A. J.; Turner, R. C.; Mann, J I

doi:10.1007/bf00283746

Cited by 75 publications

(46 citation statements)

References 22 publications

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“…Dornans group did not find any relationship between serum triglyceride levels and severity of retinopathy in insulindependent diabetic patients (Dornan et al 1982) and a study by Agardh (1988), gave the same results. On the other hand, Weber et al found that serum triglycerides were strongly associated with degree of retinopathy in children and adolescents with diabetes mellitus type 1 (Weber et al 1986).…”

Section: Discussionmentioning

confidence: 80%

“…Serum cholesterol levels were in some studies found to correlate to more severe retinopathy (Dornan et al 1982;Eckel et al 1981;Mouton & Gill 1988 ;Scanu & Fless 1990;Weber et al 1986) while in other studies such a relationship was not found (Weber et al 1986;West et al 1980). Dornan et al (1982) measured serum lipid levels in small groups of insulin-dependent diabetic patients and controls. They found higher levels of total cholesterol with more severe retinopathy; no association with high density lipoprotein levels and degree of retinopathy; and decreasing HDL/LDL ratio with more severe retinopathy.…”

Section: Discussionmentioning

confidence: 99%

“…Levels of different serum lipids have been measured in subjects with diabetes mellitus in different studies, but the correlation with retinopathy has not been consistent. Increased levels of total serum cholesterol were in some studies related to more severe retinopathy (Dornan et al 1982;Eckel et al 1981;Klein et al 1991;Mouton & Gill 1988) while in others it was not (Weber et al 1986;West et al 1980). High serum triglyceride levels have been found to correlate to more pronounced retinopathy (Eckel et al 1981;Weber et al 1986) as well as not (Agardh et al 1988;Dornan et al 1982).…”

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confidence: 99%

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The association of hyperlipidemia with retinopathy in diabetic patients aged 15‐50 years in the county of Umeå

Alm

Lithner

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To study possible associations between serum lipid levels and degree of retinopathy in a population-based study on a specific age-group of patients with diabetes mellitus in the county of Umeå, Sweden. Methods: All patients with diabetes mellitus aged 15-50 years living in the county of Umeå were invited to the study. The participating subjects had a standard clinical examination and an eye examination performed. Seven-field stereoscopic photographs were taken of each eye, and the photos were sent to Grading Center, Hammersmith Hospital, London, U.K. for grading of the retinopathy. Blood samples were drawn for analysis of lipoprotein(a), high density lipoprotein (HDL) cholesterol, cholesterol and triglycerides. Univariate and multivariate statistical analyses were performed. Results: In the present study only patients with type 1 diabetes mellitus were included, and 285 of the invited 308 diabetic subjects (93%) took part. When univariate analysis was applied we found statistically significant associations between higher lipoprotein(a) levels, higher triglyceride levels, higher cholesterol levels, lower HDL cholesterol/total cholesterol ratios and increasing severeness of retinopathy. However, in the multivariate analysis triglyceride levels lost their importance while all other significant associations were still present. Conclusion: Associations were found between higher levels of serum total cholesterol, declining ratios of high density lipoprotein (HDL) cholesterol/total cholesterol, higher levels of serum lipoprotein(a) and more severe retinopathy in diabetes mellitus type 1. No such association was found between serum triglycerides and degree of retinopathy.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The association of hyperlipidemia with retinopathy in diabetic patients aged 15‐50 years in the county of Umeå

Alm

Lithner

et al. 1999

Acta Ophthalmologica Scandinavica

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“…17 Further studies have linked LDL cholesterol with maculopathy, although numbers of patients in these studies are small. 18,19 A direct toxic effect of LDL on retinal capillary pericytes has also been demonstrated, and this toxic effect can be enhanced by LDL glycation or oxidation. In other small cross-sectional studies, lipoprotein (a) has been suggested as a risk factor for maculopathy, 20,21 although this finding is refuted on examination of a small subset of the WESDR population.…”

Section: Are Serum Lipids Associated With Increased Risk Of Maculopathy?mentioning

confidence: 99%

The role of serum lipids in exudative diabetic maculopathy: is there a place for lipid lowering therapy?

Chowdhury

Hopkins

Dodson

et al. 2002

Eye

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The treatment for diabetic maculopathy is laser photocoagulation of the pigment epithelium. With the advent of systemic lipid lowering therapy over the last decade, there may be potential for medical therapy also. There is some anecdotal evidence of the effect of lipid lowering agents (particularly statins) in reducing exudate, and a number of studies have shown that lipid lowering therapy may reduce macular exudates, but numbers in these trials are small. A randomised controlled trial is now required to investigate whether the use of systemic lipid lowering therapy is of benefit in patients with exudative maculopathy, even in the absence of dyslipidaemia.

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“…It is not possible to define which diabetic individuals will present retinopathy. However, it is possible to determine risk factors related to the development of retinopathy (5) , such as duration of systemic disease, poor diabetes control, insulin-dependent diabetes, dislipidemia, hypertension, alcoholism, pregnancy, associated renal disease, anemia hypomagnesemia and African descendant (1,(8)(9)(10)(11)(12)(13)(14)(15)(16) . Some studies suggest that retinopathy progression is almost inexistent in younger-onset diabetics (less than 13 years-old).…”

Section: Introductionmentioning

confidence: 99%

Risk factors related to the severity of diabetic retinopathy

Corrêa¹,

Freitas²,

Marcon³

2003

Arq. Bras. Oftalmol.

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Risk factors related to the severity of diabetic retinopathyPurpose: To determine the relationship between the severity or stage of diabetic retinopathy and associated risk factors in a southern Brazilian population. Methods: Transversal study of diabetic patients without previous ophthalmologic treatment, seen at a University eye clinic. These patients underwent fundus photography, complete blood work-up, systemic blood pressure measurement, urine analysis, and were questioned about risk factors previously determined by the authors. The presence or absence of risk factors was compared to the severity of diabetic retinopathy. Results: Eighty-one patients were selected, 28 male, 53 female, 55 Caucasians, 26 African descendants, 28 had insulin-dependent diabetes mellitus, 53 had non-insulin-dependent diabetes mellitus. Factors related to more severe diabetic retinopathy include: insulin-dependent diabetes mellitus (α<0.01), nephropathy (α<0.05), proteinuria (α<0.05), duration of the disease (p<0.001), elevated fasting plasma glucose (p=0.11), glycosylated hemoglobin (HbA (1c)) (p=0.001), total serum cholesterol (p=0.019), lower hematocrit (p=0.004) and hemoglobin (p=0.001). Conclusions: The severity of diabetic retinopathy appears to be associated with risk factors such as duration of disease, type of diabetes, poor metabolic control, hemoglobin levels, total cholesterol and proteinuria. Factors apparently not related to severity of diabetic retinopathy include gender, age, systemic hypertension and hypomagnesemia.

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Low density lipoprotein cholesterol: An association with the severity of diabetic retinopathy

Cited by 75 publications

References 22 publications

The association of hyperlipidemia with retinopathy in diabetic patients aged 15‐50 years in the county of Umeå

The association of hyperlipidemia with retinopathy in diabetic patients aged 15‐50 years in the county of Umeå

The role of serum lipids in exudative diabetic maculopathy: is there a place for lipid lowering therapy?

Risk factors related to the severity of diabetic retinopathy

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