The significance of adiponectin as a biomarker in metabolic syndrome and/or coronary artery disease

Stojanović, Sanja; Ilić,; Ilić, Stevan; Petrovič, Daniel; Djukic, Aleksandar

doi:10.2298/vsp140531067s

Cited by 20 publications

(16 citation statements)

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“…Moreover, multiple regression analyses by gender showed that ischemic stroke was more likely to affect the males with MUNO, whereas it was more likely to affect the females with MUNO or MUO. These results indicate that metabolism and not obesity itself causes CVD, in agreement with other studies (Millan-Nunez et al 2016; Stojanović et al 2015; Turker et al 2015). However, the differing results according to gender require further investigation.…”

Section: Discussionsupporting

confidence: 92%

Metabolism rather than obesity is associated with ischemic stroke: a cross-sectional study in rural Northeastern China

et al. 2016

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Little is known about stroke with different obesity phenotype as determined using the Adult Treatment Panel-III criteria with metabolic health or not. This study aimed to investigate the effects of metabolically healthy and unhealthy obesity on ischemic stroke in a general population. A total of 11,150 adults were examined using a multi-stage cluster sampling method to select a representative sample of individuals 35 years or older. Ischemic stroke was defined as history of a cerebrovascular event, as documented by doctors via either cranial CT or MR scan within the past 2 years. All subjects were categorized as having metabolically healthy non-obesity (MHNO), metabolically unhealthy non-obesity (MUNO), metabolically healthy obesity (MHO) or metabolically unhealthy obesity (MUO) using the Adult Treatment Panel-III criteria. Stratified analysis were done based on different body mass index group. For the total population, multiple regression analyses revealed that individuals with MUNO and MUO were more likely to experience ischemic stroke compared with those with MHNO (OR 2.136, 95 % CI 1.677–2.720; OR 2.712, 95 % CI 1.798–4.092; all p < 0.001). The OR for ischemic stroke did not significantly differ between MHO and MHNO. Stratification based on different BMI group showed that, compared with people who were normal weight without Mes, participants who were in Mes with overweight or obesity had significantly higher OR for ischemic stroke(both p < 0.05); participants who were not in Mes with overweight or obesity did not showed OR significantly higher. Ischemic stroke is likely associated with poor metabolic health rather than with obesity itself.

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Section: Discussionsupporting

confidence: 92%

Metabolism rather than obesity is associated with ischemic stroke: a cross-sectional study in rural Northeastern China

et al. 2016

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“…Adiponectin levels are lower in patients with essential hypertension and type-2 diabetes, and adiponectin is associated with insulin resistance, triglycerides and HDL cholesterol levels (Lihn, Pedersen, & Richelsen, 2005;Nigro et al, 2014;Vaiopoulos, Marinou, Christodoulides, & Koutsilieris, 2012). Given its role in metabolic diseases, adiponectin may be important in tracking and diagnosing some of the most rapidly growing and costly diseases in the United States (e.g., prediabetes/insulin resistance, metabolic syndrome, and vascular disease; Ebrahimi-Mamaeghani, Mohammadi, Arefhosseini, Fallah, & Bazi, 2015;Lopez-Jaramillo et al, 2014;Stojanović, Ilić, Ilić, Petrović, & Djukić, 2015).…”

Section: Introductionmentioning

confidence: 99%

Adiponectin: Serum-saliva associations and relations with oral and systemic markers of inflammation

Riis

Bryce

et al. 2017

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This study addresses gaps in our understanding about the validity and utility of using salivary adiponectin to index serum adiponectin levels. Matched blood and saliva samples were collected on a single occasion from healthy adults (n= 99; age 18-36 years, 53% male). Serum and saliva was assayed for adiponectin and inflammatory cytokines (IL-1β, IL-6, IL-8, TNFα), and saliva was also assayed for markers of blood contamination (transferrin), total protein (salivary flow rate) and matrix metalloproteinase-8 (MMP-8). We examined the extent to which salivary adiponectin was associated with serum adiponectin, and the influence of potential confounders on the serum-saliva correlation, including age, sex, body mass index, and markers of inflammation, oral health, salivary blood contamination, and flow rate. Findings revealed a modest serum-saliva association for adiponectin, and strong positive associations between salivary adiponectin and salivary levels of inflammatory cytokines, MMP-8, transferrin, and total protein. By contrast, salivary adiponectin was not related to serum levels of inflammatory activity. The magnitude of the serum-saliva association was strengthened when controlling for total protein in saliva, blood leakage into oral fluid, salivary inflammatory cytokines, and MMP-8. The pattern of findings extends our understanding of salivary adiponectin and its potential use as an index of circulating adiponectin levels.

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“…This observation is in concordance with previous data. It was demonstrated that lowlevel adiponectin subjects were characterized by a significantly higher prevalence of some cardiometabolic comorbidities (obesity, visceral obesity, DM, insulin resistance, LV hypertrophy, metabolic syndrome, CAD) [26,31,32].…”

Section: Discussionmentioning

confidence: 99%

Severe degenerative aortic stenosis with preserved ejection fraction does not change adipokines serum levels

et al. 2019

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The significance of adiponectin as a biomarker in metabolic syndrome and/or coronary artery disease

Abstract: The obtained resultats suggest that adiponectin may be a useful marker in identification of individuals with risk of developing metabolic syndrome and coronary artery disease, as well as a predictor of prediabetes.

Cited by 20 publications

References 0 publications

Metabolism rather than obesity is associated with ischemic stroke: a cross-sectional study in rural Northeastern China

Metabolism rather than obesity is associated with ischemic stroke: a cross-sectional study in rural Northeastern China

Adiponectin: Serum-saliva associations and relations with oral and systemic markers of inflammation

Severe degenerative aortic stenosis with preserved ejection fraction does not change adipokines serum levels

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